Recombinant Human RYK protein, His & T7-tagged

Cat.No. : RYK-1937H
Product Overview : Recombinant Human RYK aa. (Lys308~Cys570 (Accession # NM_001005861.2)) fused with N-terminal His & T7 tag was produced in E. coli cells.
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Description : The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the regulation of axon pathfinding. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Source : E. coli
Species : Human
Tag : His&T7
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 33.7kDa
Protein length : Lys308~Cys570 (Accession # NM_001005861.2)
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : >95%
Applications : SDS-PAGE; WB; ELISA; IP.
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage buffer : Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.
Isoelectric Point : 6
Gene Name : RYK receptor-like tyrosine kinase [ Homo sapiens (human) ]
Official Symbol : RYK
Synonyms : RYK; receptor-like tyrosine kinase; JTK5; RYK1; JTK5A; D3S3195; tyrosine-protein kinase RYK; JTK5A protein tyrosine kinase; hydroxyaryl-protein kinase
Gene ID : 6259
mRNA Refseq : NM_001005861.2
Protein Refseq : NP_001005861.1
UniProt ID : P34925

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