Recombinant Human RYK Protein, MYC/DDK-tagged

Cat.No. : RYK-2012H
Product Overview : Recombinant human RYK protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293
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Description : The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the regulation of axon pathfinding. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012].
Source : HEK293
Species : Human
Tag : Myc&DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 67.9 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : RYK receptor-like tyrosine kinase [ Homo sapiens ]
Official Symbol : RYK
Synonyms : D3S3195; JTK5; JTK5A; RYK1
Gene ID : 6259
mRNA Refseq : NM_001005861
Protein Refseq : NP_001005861
MIM : 600524
UniProt ID : P34925

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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