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Official Full Name regulator of calcineurin 2
Background This gene encodes a member of the regulator of calcineurin (RCAN) protein family. These proteins play a role in many physiological processes by binding to the catalytic domain of calcineurin A, inhibiting calcineurin-mediated nuclear translocation of the transcription factor NFATC1. Expression of this gene in skin fibroblasts is upregulated by thyroid hormone, and the encoded protein may also play a role in endothelial cell function and angiogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Synonyms RCAN2; regulator of calcineurin 2; Down syndrome critical region gene 1 like 1 , DSCR1L1; calcipressin-2; ZAKI 4; Calcipressin 2; CSP2; Down syndrome candidate region 1-like 1; Down syndrome critical region gene 1 like 1 protein; MCIP2; Myocyte enriched calcineurin interacting protein 2; Myocyte-enriched calcineurin-interacting protein 2; RCAN2_HUMAN; RCN2; Thyroid hormone responsive protein ZAKI4; Thyroid hormone-responsive protein ZAKI-4; ZAKI4; Down syndrome critical region gene 1-like 1; thyroid hormone-responsive (skin fibroblasts); ZAKI-4; DSCR1L1
    • Species :
    • Human
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Human
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human Rcan2-1562M Recombinant Human Regulator Of Calcineurin 2, His-tagged E.coli His
    Human RCAN2-2449HCL Recombinant Human RCAN2 293 Cell Lysate HEK293 N/A
    Human RCAN2-28376TH Recombinant Human RCAN2, His-tagged E.coli His
    Human RCAN2-4031H Recombinant Human RCAN2 Protein, GST-tagged Wheat Germ GST
    Human RCAN2-4750H Recombinant Human Regulator Of Calcineurin 2, His-tagged Human His
    Human RCAN2-6859H Recombinant Human Regulator Of Calcineurin 2, His-tagged E.coli His
    Human RCAN2-713H Recombinant Human RCAN2 Protein, GST/His-tagged E.coli GST/His
    Rat RCAN2-4973R Recombinant Rat RCAN2 Protein Mammalian Cell His
    Zebrafish RCAN2-12828Z Recombinant Zebrafish RCAN2 Mammalian Cell His

    Rcan2 involved in several pathways and played different roles in them. We selected most pathways Rcan2 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with Rcan2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Calcium signaling in the CD4+ TCR pathway FKBP1A; RCAN1; BATF3; AKAP5; CHP; POU2F1; JUNB; CSF2; RCAN2
    Role of Calcineurin-dependent NFAT signaling in lymphocytes RCAN1; FKBP8; RCAN2; CHP
    Thyroid hormone signaling pathway PRKCB; ACTB; PIK3CA; MAP2K1; RHEB; TP53; PLCE1; MAPK1; NCOR1; MDM2

    Rcan2 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by Rcan2 itself. We selected most functions Rcan2 had, and list some proteins which have the same functions with Rcan2. You can find most of the proteins on our site.

    Function Related Protein
    calcium-dependent protein serine/threonine phosphatase regulator activity RCAN3; RCAN1A; RCAN1; RCAN2
    nucleotide binding DQX1; GNA15.4; RBM39A; RBM17; CKMT2A; DDX19; MYO6B; RBMS1; PPP1R2P9; POLD1

    Rcan2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Rcan2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Rcan2.


    Qin, WP; Pan, JP; et al. Anabolic steroids activate calcineurin-NFAT signaling and thereby increase myotube size and reduce denervation atrophy. MOLECULAR AND CELLULAR ENDOCRINOLOGY 399:336-345(2015).
    Skoda, G; Kerekes, A; et al. Examination of a regulatory SNP of bovine RCAN2 gene in transgenic mouse models. TRANSGENIC RESEARCH 23:889-889(2014).

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