Recombinant Human RCAN2, His-tagged

• Cat.No.: RCAN2-28376TH
• Product Overview: Recombinant full length Human DSCR1L1 with an N terminal His tag; 217 amino acids with tag; Predicted MWt 24.1 kDa inclusive of tag.

Specification

• Description: This gene encodes a member of the regulator of calcineurin (RCAN) protein family. These proteins play a role in many physiological processes by binding to the catalytic domain of calcineurin A, inhibiting calcineurin-mediated nuclear translocation of the transcription factor NFATC1. Expression of this gene in skin fibroblasts is upregulated by thyroid hormone, and the encoded protein may also play a role in endothelial cell function and angiogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
• Protein length: 197 amino acids
• Conjugation: HIS
• Molecular Weight: 24.100kDa inclusive of tags
• Source: E. coli
• Tissue specificity: Expressed in fibroblasts, heart, brain, liver, and skeletal muscle but not in placenta, lung, kidney and pancreas.
• Form: Liquid
• Purity: by SDS-PAGE
• Storage buffer: pH: 8.00Constituents:20% Glycerol, 0.02% DTT, 0.32% Tris HCl, 1.17% Sodium chloride
• Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MPAPSMDCDV STLVACVVDV EVFTNQEVKE KFEGLFRTYD DCVTFQLFKS FRRVRINFSN PKSAARARIE LHETQFRGKK LKLYFAQVQT PETDGDKLHL APPQPAKQFL ISPPSSPPVG WQPINDATPV LNYDLLYAVA KLGPGEKYEL HAGTESTPSV VVHVCDSDIE EEEDPKTSPK PKIIQTRRPG LPPSVSN
• Sequence Similarities: Belongs to the RCAN family.

Gene Information

• Gene Name: RCAN2 regulator of calcineurin 2 [ Homo sapiens ]
• Official Symbol: RCAN2
• Synonyms: RCAN2; regulator of calcineurin 2; Down syndrome critical region gene 1 like 1 , DSCR1L1; calcipressin-2; ZAKI 4
• Gene ID: 10231
• mRNA Refseq: NM_005822
• Protein Refseq: NP_005813
• MIM: 604876
• Uniprot ID: Q14206
• Chromosome Location: 6p12.3
• Pathway: Calcium signaling in the CD4+ TCR pathway, organism-specific biosystem; Role of Calcineurin-dependent NFAT signaling in lymphocytes, organism-specific biosystem
• Function: nucleotide binding; protein phosphatase 2B binding