sdc4
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  • Official Full Name
  • syndecan 4
  • Background
  • Syndecan-4 is a protein that in humans is encoded by the SDC4 gene. Syndecan-4 is one of the four vertebrate syndecans and has a molecular weight of ~20 kDa. Syndecans are the best-characterized plasma membrane proteoglycans. Their intracellular domain of membrane-spanning core protein interacts with actin cytoskeleton and signaling molecules in the cell cortex. Syndecans are normally found on the cell surface of fibroblasts and epithelial cells. Syndecans interact with fibronectin on the cell surface, cytoskeletal and signaling proteins inside the cell to modulate the function of integrin in cell-matrix adhesion. Also, syndecans bind to FGFs and bring them to the FGF receptor on the same cell. As a co-receptor or regulator, mutated certain proteoglycans could cause severe developmental defects, like disordered distribution or inactivation of signaling molecules.
  • Synonyms
  • SDC4; SYND4; syndecan 4; Syndecan 4; amphiglycan; ryudocan amphiglycan; ryudocan core protein; syndecan proteoglycan 4; syndecan 4 (amphiglycan, ryudocan)
Cat.#:SDC4-411HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human SDC4 Protein (Met1-Glu145), His-tagged
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Cat.#:SDC4-18HTag:N/A
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human SDC4 protein
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Cat.#:SDC4-19HTag:His
Source (Host):NS0Species:Human
Product nameRecombinant Human SDC4, His-tagged
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Cat.#:SDC4-2425HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human Syndecan 4, Fc Chimera
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Cat.#:SDC4-4631HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Syndecan 4
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Cat.#:SDC4-505HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human SDC4, Fc-tagged
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Cat.#:Sdc4-1993MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Sdc4 protein, His-tagged
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Cat.#:SDC4-387MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Sdc4, Fc tagged
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Cat.#:Sdc4-7017MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Sdc4, His tagged
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Cat.#:Sdc4-963MTag:His
Source (Host):NSO CellsSpecies:Mouse
Product nameRecombinant Mouse Sdc4 Protein, His-tagged
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Cat.#:Sdc4-1994RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Sdc4 protein, His-tagged
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Cat.#:SDC4-5286RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SDC4 Protein
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Cat.#:SDC4-4107RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SDC4 Protein, His-tagged
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Cat.#:SDC4-1782CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SDC4
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Cat.#:SDC4-1992CTag:His|T7
Source (Host):E. coliSpecies:Chicken
Product nameRecombinant Chicken SDC4 protein, His & T7-tagged
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Cat.#:SDC4-4449ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SDC4
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Cat.#:SDC4-1057MCLTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse SDC4 cell lysate
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Involved Pathway

SDC4 involved in several pathways and played different roles in them. We selected most pathways SDC4 participated on our site, such as ECM-receptor interaction, Cell adhesion molecules (CAMs), Proteoglycans in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with SDC4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ECM-receptor interaction
SV2A; ITGB3; COL6A3; COL1A1B; ITGB5; LAMA3; SDC1; THBS3; TNR; COL27A1B
Cell adhesion molecules (CAMs)
ITGAM; MAG; H2-AA; CD86; CNTNAP2; ICAM3; MHC2DCB; ITGB8; NRXN2; OCLN
Proteoglycans in cancer
CAMK2D; STAT3; PLCE1; PRKCA; PTCH1; TFAP4; HGF; ANK2; CAMK2A; VAV2

Protein Function

SDC4 has several biochemical functions, for example, fibronectin binding, protein binding, protein kinase C binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SDC4 itself. We selected most functions SDC4 had, and list some proteins which have the same functions with SDC4. You can find most of the proteins on our site.
Function
Related Protein
Function fibronectin binding
Related Protein CTSS; CTGF; LPA; CTSK; MMP13; VEGFA; ITGAV; HSD17B12; LRRC15; FSTL3
Function protein binding
Related Protein FRAG1; EHMT1; PPP1R3C; RAMP2; BAZ1B; ETV6; PARN; EGLN1; SIVA1; GNAI1
Function protein kinase C binding
Related Protein PAWR; PLEK; TDG; YWHAG; PARD6A; TWF2; PKP2; LDB3; DSP; AVPR1B
Function thrombospondin receptor activity
Related Protein F2; SDC4; CD47

Interacting Protein

SDC4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SDC4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SDC4.
SGTA; PRKCA; GIPC1; PECAM1; TGFB3; TANK; DBN1; Lima1