serpina1
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  • Official Full Name
  • serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
  • Background
  • The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene.
  • Synonyms
  • SERPINA1; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1; PI; A1A; AAT; PI1; A1AT; MGC9222; PRO2275; MGC23330; serine proteinase inhibitor, clade A, member 1; OTTHUMP00000197150; protease inhibitor 1 (anti-elastase), alpha-1-antitrypsin serine (or cysteine) proteinase inhibitor, clade A, member 1
Cat.#:SERPINA1-866HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human SERPINA1 Protein, MYC/DDK-tagged
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Cat.#:SERPINA1-050HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SERPINA1 Protein, His-tagged
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Cat.#:SERPINA1-258HTag:
Source (Host):Rice GrainSpecies:Human
Product nameRecombinant Human SERPINA1 protein
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Cat.#:SERPINA1-518HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SERPINA1
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Cat.#:SERPINA1-854HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human SERPINA1, His tagged
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Cat.#:Serpina1a-3309MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse Serpina1a, His-tagged
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Cat.#:a1AT-3308RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat a1AT, His-tagged
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Cat.#:SERPINA1-1119RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat SERPINA1 Protein, His-tagged
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Cat.#:SERPINA1-5334RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SERPINA1 Protein
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Cat.#:SERPINA1-4147RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SERPINA1 Protein, His-tagged
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Cat.#:SERPINA1-4886CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SERPINA1
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Cat.#:SERPINA1-4841ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SERPINA1
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Cat.#:SERPINA1-256HTag:His
Source (Host):Mammalian CellsSpecies:Horse
Product nameRecombinant Horse SERPINA1 protein, His-tagged
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Cat.#:SERPINA1-011OTag:N/A
Source (Host):RiceSpecies:Human
Product nameRecombinant Human SERPINA1
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Cat.#:SERPINA1-27286THTag:
Source (Host):Species:Human
Product nameNative Human SERPINA1
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Cat.#:SERPINA1-5358HTag:N/A
Source (Host):Human plasmaSpecies:Human
Product nameNative Human Serpin Peptidase Inhibitor, Clade A (alpha-1 antiproteinase, antitrypsin), Member 1
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Cat.#:SERPINA1-8009HTag:N/A
Source (Host):Human plasmaSpecies:Human
Product nameNative Human Serum Alpha 1 AntiTrypsin
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Cat.#:SERPINA1-2856HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human SERPINA1 cell lysate
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Cat.#:SERPINA1-20HTag:
Source (Host):Species:Human
Product nameAlpha-1-Antitrypsin(plasma derived) Reference standard
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Cat.#:SERPINA1-4HTag:
Source (Host):Species:Human
Product nameHuman Alpha 1-Antitrypsin Reference Standard
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Cat.#:SERPINA1-32MTag:N/A
Source (Host):Species:Mouse
Product nameMouse Alpha 1-Antitrypsin Reference Standard
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Cat.#:SERPINA1-17DTag:N/A
Source (Host):Species:Dog
Product nameDog Alpha 1-Antitrypsin Reference Standard
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Involved Pathway

SERPINA1 involved in several pathways and played different roles in them. We selected most pathways SERPINA1 participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with SERPINA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Complement and coagulation cascades
Serpina1c; FGA; C9; SERPINA1; PLAT; C1QB; LOC100514666; SERPINF2; F5; KLKB1

Protein Function

SERPINA1 has several biochemical functions, for example, glycoprotein binding, identical protein binding, protease binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SERPINA1 itself. We selected most functions SERPINA1 had, and list some proteins which have the same functions with SERPINA1. You can find most of the proteins on our site.
Function
Related Protein
Function glycoprotein binding
Related Protein SDCBP; LRRK2; SERPINA1E; CANX; THBS1; ITGAM; SERPINA1D; APOH; BMPR1A; BMPR1B
Function identical protein binding
Related Protein PDGFB; PYDC3; PPP5C; SERPINA1A; MID1; CBY1; MMP9; FTL; OMG; NDC80
Function protease binding
Related Protein SERPINB13; HSPA6; KIT; ITGAV; PEO1; CCBE1; SERPINA1; MBL1; C10orf2; LRP1
Function protein binding
Related Protein DAAM1; CBFB; HDLBP; PSMA2; SPAG5; TICAM2; ARSA; ESR2; MITD1; SLC6A20
Function serine-type endopeptidase inhibitor activity
Related Protein SPINK4; WFDC3; APPB; SERPINB1L2; HRG; SPINK3; FURIN; PAPLN; APP; SPINK2

Interacting Protein

SERPINA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SERPINA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SERPINA1.
try1_bovin; CELA1; SSR1; ELANE; tryp_sacer; CANX; espB

SERPINA1 Related Articles

Watts, RA; MacGregor, AJ; et al. HLA allele variation as a potential explanation for the geographical distribution of granulomatosis with polyangiitis. RHEUMATOLOGY 54:359-362(2015).
Perez-Rubio, G; Jimenez-Valverde, LO; et al. Prevalence of alpha-1 antitrypsin high-risk variants in Mexican mestizo population and their association with lung function values. ARCHIVOS DE BRONCONEUMOLOGIA 51:80-85(2015).