SETD2 Protein, SET domain containing 2


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Official Full Name SET domain containing 2
Background Huntingtons disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II. [provided by RefSeq, Aug 2008]
Synonyms SETD2; SET domain containing 2; HYPB; SET2; HIF-1; HIP-1; KMT3A; HBP231; HSPC069; p231HBP; histone-lysine N-methyltransferase SETD2; huntingtin yeast partner B; lysine N-methyltransferase 3A; huntingtin interacting protein 1; huntingtin-interacting protein B;
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • Flag
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SETD2-023H Recombinant Human SETD2 Protein, His-tagged E.coli His
    Human SETD2-188H Recombinant Human SETD2 Protein, GST-tagged E.coli GST
    Human SETD2-189H Recombinant Human SETD2 Protein, His-tagged E.coli His
    Human SETD2-199H Recombinant Human SETD2 protein, GST-tagged, Active Insect Cell GST
    Human SETD2-259H Recombinant Human SETD2 protein E.coli N/A
    Human SETD2-260H Recombinant Human SETD2 protein, GST-tagged E.coli GST
    Human SETD2-27850TH Recombinant Human SETD2 E.coli N/A
    Human SETD2-460H Recombinant Human SET Domain Containing 2, GST-tagged E.coli GST
    Human SETD2-461H Recombinant Human SETD2, GST-tagged E.coli GST
    Human SETD2-69H Recombinant Human SETD2, FLAG-tagged Sf9 Insect Cell Flag
    Mouse SETD2-14979M Recombinant Mouse SETD2 Protein Mammalian Cell His
    Kit-1864 SETD2 Chemiluminescent Assay Kit N/A

    SETD2 involved in several pathways and played different roles in them. We selected most pathways SETD2 participated on our site, such as Lysine degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with SETD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Lysine degradation ALDH2.1; KMT2E; CAMKMT; KMT2A; SETD1B; SUV39H1B; SETDB1B; TMLHE; SETD8A; SETD1BA

    SETD2 has several biochemical functions, for example, histone methyltransferase activity (H3-K36 specific), histone-lysine N-methyltransferase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SETD2 itself. We selected most functions SETD2 had, and list some proteins which have the same functions with SETD2. You can find most of the proteins on our site.

    Function Related Protein
    histone methyltransferase activity (H3-K36 specific) SMYD2A; SETD2; SMYD2; SETMAR; ASH1L; NSD1; SETD3; SMYD2B
    histone-lysine N-methyltransferase activity EZH2; DOT1L; SUV420H1; SMYD1; SUV39H1; WBP7; EHMT1; SETD7; SETDB1; MLL5
    protein binding FBXO5; AKT1; TRAF6; DDX3X; STOML1; ERC1; HMOX2; TTC37; PITX2; ATP6V0D1

    SETD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SETD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SETD2.

    SMAD3; SIAH2; HTT; ATXN1; fdoH; argS; CIC; q9wmx2-pro_0000037541; q9wmx2-pro_0000037544; q9wmx2-pro_0000037545; q9wmx2-pro_0000037547; q9wmx2-pro_0000037552; Soga1; Ttll7; CLK2; RASSF8

    Newbold, RF; Mokbel, K; et al. Evidence for a Tumour Suppressor Function of SETD2 in Human Breast Cancer: A New Hypothesis. ANTICANCER RESEARCH 30:3309-3311(2010).

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