|Official Full Name||SET domain containing 2|
|Background||Huntingtons disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II. [provided by RefSeq, Aug 2008]|
|Synonyms||SETD2; SET domain containing 2; HYPB; SET2; HIF-1; HIP-1; KMT3A; HBP231; HSPC069; p231HBP; histone-lysine N-methyltransferase SETD2; huntingtin yeast partner B; lysine N-methyltransferase 3A; huntingtin interacting protein 1; huntingtin-interacting protein B;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
SETD2 involved in several pathways and played different roles in them. We selected most pathways SETD2 participated on our site, such as Lysine degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with SETD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Lysine degradation||ALDH2.1; KMT2E; CAMKMT; KMT2A; SETD1B; SUV39H1B; SETDB1B; TMLHE; SETD8A; SETD1BA|
SETD2 has several biochemical functions, for example, histone methyltransferase activity (H3-K36 specific), histone-lysine N-methyltransferase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SETD2 itself. We selected most functions SETD2 had, and list some proteins which have the same functions with SETD2. You can find most of the proteins on our site.
|histone methyltransferase activity (H3-K36 specific)||SMYD2A; SETD2; SMYD2; SETMAR; ASH1L; NSD1; SETD3; SMYD2B|
|histone-lysine N-methyltransferase activity||EZH2; DOT1L; SUV420H1; SMYD1; SUV39H1; WBP7; EHMT1; SETD7; SETDB1; MLL5|
|protein binding||FBXO5; AKT1; TRAF6; DDX3X; STOML1; ERC1; HMOX2; TTC37; PITX2; ATP6V0D1|
SETD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SETD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SETD2.
SMAD3; SIAH2; HTT; ATXN1; fdoH; argS; CIC; q9wmx2-pro_0000037541; q9wmx2-pro_0000037544; q9wmx2-pro_0000037545; q9wmx2-pro_0000037547; q9wmx2-pro_0000037552; Soga1; Ttll7; CLK2; RASSF8