siglec5
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  • Official Full Name
  • sialic acid binding Ig-like lectin 5
  • Background
  • This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface;lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition;sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits;the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B;Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion.
  • Synonyms
  • SIGLEC5; sialic acid binding Ig-like lectin 5; CD33L2; sialic acid-binding Ig-like lectin 5; CD170; OB BP2; SIGLEC 5; CD33 antigen-like 2; OB-binding protein 2; obesity-binding protein 2; sialic acid-binding immunoglobulin-like lectin 5; OBBP2; OB-BP2; SI
Cat.#:SIGLEC5-428HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human SIGLEC5 Protein
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Cat.#:SIGLEC5-5674HTag:His|S
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SIGLEC5 protein, His & S-tagged
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Cat.#:SIGLEC5-7330HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human SIGLEC5, Fc tagged
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Cat.#:SIGLEC5-941HTag:Fc
Source (Host):NSO CellsSpecies:Human
Product nameRecombinant Human SIGLEC5 Protein, Fc Chimera
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Cat.#:SIGLEC5-1596RTag:N/A
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey SIGLEC5 Protein
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Cat.#:SIGLEC5-1075HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human SIGLEC5 cell lysate
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Cat.#:SIGLEC5-1505HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human SIGLEC5 cell lysate
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Involved Pathway

SIGLEC5 involved in several pathways and played different roles in them. We selected most pathways SIGLEC5 participated on our site, such as Adaptive Immune System, Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, which may be useful for your reference. Also, other proteins which involved in the same pathway with SIGLEC5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
UBE2E3; CTSC; CTSL2; ASB13; CTSLL; GM11711; ASB4; SIGLEC6; RNF6; CRTAM
Immune System
TRIM10; RNF144B; DEFA5; CTSC; MYO9B; TRIM3; EDA; KLRF1; SUGT1; GBP5
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
SIGLEC10; TREML2; AF251705; SIGLEC6; CD200; SIGLEC7; CD300LB; KIR2DS2; LAIR1; Siglece

Protein Function

SIGLEC5 has several biochemical functions, for example, carbohydrate binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SIGLEC5 itself. We selected most functions SIGLEC5 had, and list some proteins which have the same functions with SIGLEC5. You can find most of the proteins on our site.
Function
Related Protein
Function carbohydrate binding
Related Protein SELL; CLEC18B; PVRL1; KLRA8; APCS; LMAN2; LGALS1L1; MAN2A1; SORD; CD302
Function protein binding
Related Protein ARHGAP26; SLPI; LAPTM5; UPK3A; NRIP1; GPAA1; PNMA1; DPM2; CTC1; HYAL2

Interacting Protein

SIGLEC5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIGLEC5 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIGLEC5.
TRIP13; VAC14; q7cjv9_yerpe