Recombinant Human SIGLEC5 Protein (17-441), C-Fc/Avi-tagged, Biotin-labeled

• Cat.No.: SIGLEC5-34H
• Product Overview: Human secreted Sialic Acid Binding Ig Like Lectin 5 (Siglec5)-Fc fusion protein, also known as CD33L2 and OBBP2, GenBank Accession No. NM_003830, a.a. 17-441, fused at the C-terminus of the Fc portion of human IgG1, with C-terminal Avi-tag, expressed in a HEK293 cell expression system and enzymatically biotinylated using Avi-tag™ technology.

Specification

• Species: Human
• Source: HEK293
• Tag: Avi&Fc
• Protein Length: 17-441
• Description: This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion.
• Form: Aqueous buffer solution.
• Molecular Mass: 76 kDa
• Notes: Thaw on ice and gently mix prior to use. DO NOT VORTEX. Perform a quick spin before opening. Aliquot into small volumes and flash freeze for long term storage. Avoid multiple freeze/thaw cycles.
• Storage: At least 6 months at –80 centigrade.
• Storage Buffer: 8 mM Phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol.
• Shipping: At -80 centigrade
• Warning: Avoid freeze/thaw cycles.
• Conjugation: Biotin

Gene Information

• Gene Name: SIGLEC5 sialic acid binding Ig like lectin 5 [ Homo sapiens (human) ]
• Official Symbol: SIGLEC5
• Synonyms: SIGLEC5; sialic acid binding Ig like lectin 5; CD170; OBBP2; CD33L2; OB-BP2; SIGLEC-5; sialic acid-binding Ig-like lectin 5; CD33 antigen-like 2; OB-binding protein 2; obesity-binding protein 2; sialic acid-binding immunoglobulin-like lectin 5
• Gene ID: 8778
• mRNA Refseq: NM_003830
• Protein Refseq: NP_003821
• MIM: 604200
• UniProt ID: O15389