| Description : |
This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Fc |
| Form : |
Lyophilized |
| Molecular Mass : |
73 kDa |
| Protein Length : |
551 |
| AA Sequence : |
MLPLLLLPLLWGGSLQEKPVYELQV QKSVTVQEGLCVLVPCSFSYPWRSW YSSPPLYVYWFRDGEIPYYAEVVAT NNPDRRVKPETQGRFRLLGDVQKKN CSLSIGDARMEDTGSYFFRVERGRD VKYSYQQNKLNLEVTALIEKPDIHF LEPLESGRPTRLSCSLPGSCEAGPP LTFSWTGNALSPLDPETTRSSELTL TPRPEDHGTNLTCQMKRQGAQVTTE RTVQLNVSYAPQTITIFRNGIALEI LQNTSYLPVLEGQALRLLCDAPSNP PAHLSWFQGSPALNATPISNTGILE LRRVRSAEEGGFTCRAQHPLGFLQI FLNLSVYSLPQLLGPSCSWEAEGLH CRCSFRARPAPSLCWRLEEKPLEGN SSQGSFKVNSSSAGPWANSSLILHG GLSSDLKVSCKAWNIYGSQSGSVLL LQGRSNLGTGVVPAALGGAGVMALL CICLCLIFFLIVKARRKQAAGRPEK MDDEDPIMGTITSGSRKKPWPDSPG DQASPPGDAPPLEEQKELHYASLSF SEMKSREPKDQEAPSTTEYSEIKTS K |
| Purity : |
> 98% |
| Applications : |
WB; ELISA; FACS; FC |
| Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
| Storage : |
At -20 centigrade. |
| Concentration : |
1 mg/mL |
| Storage Buffer : |
PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
| Reconstitution : |
Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
