Recombinant Human SIGLEC5 protein, His & S-tagged

• Cat.No.: SIGLEC5-5674H
• Product Overview: Recombinant Human SIGLEC5 aa. (Asp147~Pro335 (Accession # O15389)) fused with N-terminal His & S tag was produced in E. coli cells.

Specification

• Description: This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion.
• Source: E. coli
• Species: Human
• Tag: His & S
• Form: Freeze-dried powder
• Molecular Mass: 26 kDa as determined by SDS-PAGE reducing conditions.
• Protein length: Asp147~Pro335 (Accession # O15389)
• Endotoxin: <1.0EU per 1µg (determined by the LAL method)
• Purity: >95%
• Characteristic: The isoelectric point is 5.7.
• Applications: SDS-PAGE; WB; ELISA; IP.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Storage buffer: Supplied as liquid form in Phosphate buffered saline(PBS), pH 7.4.
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.

Gene Information

• Gene Name: SIGLEC5 sialic acid binding Ig like lectin 5 [ Homo sapiens (human) ]
• Official Symbol: SIGLEC5
• Synonyms: SIGLEC5; sialic acid binding Ig like lectin 5; CD170; OBBP2; CD33L2; OB-BP2; SIGLEC-5; sialic acid-binding Ig-like lectin 5; CD33 antigen-like 2; OB-binding protein 2; obesity-binding protein 2; sialic acid-binding immunoglobulin-like lectin 5
• Gene ID: 8778
• mRNA Refseq: NM_003830.3
• Protein Refseq: NP_003821.1
• UniProt ID: O15389