sirt3
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  • Official Full Name
  • sirtuin 3
  • Background
  • This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms
  • SIRT3; sirtuin 3; SIR2L3; NAD-dependent protein deacetylase sirtuin-3, mitochondrial; sir2-like 3; sirtuin type 3; SIR2-like protein 3; regulatory protein SIR2 homolog 3; NAD-dependent deacetylase sirtuin-3, mitochondrial; silent mating type information regulation 2, S.cerevisiae, homolog 3; mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase;
Cat.#:SIRT3-2681HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SIRT3, GST-tagged
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Cat.#:SIRT3-2747HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Sirtuin 3, His-tagged
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Cat.#:SIRT3-30594THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SIRT3, His-tagged
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Cat.#:SIRT3-341HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SIRT3
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Cat.#:SIRT3-345HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SIRT3, His-tagged
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Cat.#:SIRT3-346HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SIRT3, His-tagged
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Cat.#:SIRT3-347HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SIRT3, GST-tagged
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Cat.#:SIRT3-4877HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Sirtuin 3, GST-tagged
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Cat.#:SIRT3-4878HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Sirtuin 3, GST-tagged
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Cat.#:SIRT3-699HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human SIRT3
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Cat.#:Sirt3-1375MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Sirt3 protein, His-tagged
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Cat.#:Sirt3-1376RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Sirt3 protein, His-tagged
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Cat.#:SIRT3-4341CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SIRT3
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Cat.#:SIRT3-5033ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SIRT3
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Cat.#:SIRT3-1832HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human SIRT3 293 Cell Lysate
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Cat.#:SIRT3-1833HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human SIRT3 293 Cell Lysate
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Involved Pathway

SIRT3 involved in several pathways and played different roles in them. We selected most pathways SIRT3 participated on our site, such as Central carbon metabolism in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with SIRT3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Central carbon metabolism in cancer
SLC2A2; PDGFRB; MET; SLC1A5; PGAM2; GLS2; G6PDX; G6PD; HK2; AKT2

Protein Function

SIRT3 has several biochemical functions, for example, NOT NAD+ ADP-ribosyltransferase activity, NAD+ binding, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SIRT3 itself. We selected most functions SIRT3 had, and list some proteins which have the same functions with SIRT3. You can find most of the proteins on our site.
Function
Related Protein
Function NOT NAD+ ADP-ribosyltransferase activity
Related Protein SIRT3; SIRT1; SIRT2; SIRT5
Function NAD+ binding
Related Protein SIRT4; GLUD1; SIRT5; HPGD; UXS1; HADH; SIRT1; SIRT3; SIRT2; SIRT6
Function enzyme binding
Related Protein CYP1A2; MAPT; SRC; TH; SLC18A1; RPS19BP1; PICK1; GNB2L1; CBS; RARA
Function hydrolase activity
Related Protein CAPN1A; CNOT6L; MCPT8; ZRANB3; ATP9B; PXYLP1; LTV1; TMPRSS11G; TMPRSS13A; GPN3
Function protein binding
Related Protein UBE2D1; ADAM8; CORO1C; MAX; UCHL3; BAP1; RHOG; PTPN11; MYPOP; NFATC2
Function zinc ion binding
Related Protein NPSN; MAN2C1; KDM2A; NANOS1; ANKIB1A; SHPRH; OTUD7B; RNF123; RC3H2; DTNBB

Interacting Protein

SIRT3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIRT3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIRT3.
SKP2; OPA1; ATP5A1; DLAT; Ppif; b3kms0_human; FOXO3; UGDH; SBF1; HERC2; ALDH2; ATP5B; UQCRH

SIRT3 Related Articles

Auburger, G; Gispert, S; et al. Mitochondrial Acetylation and Genetic Models of Parkinson's Disease. MITOCHONDRION IN AGING AND DISEASE 127:155-182(2014).
Nguyen, TTM; Wong, R; et al. Cyclophilin D Modulates Mitochondrial Acetylome. CIRCULATION RESEARCH 113:1308-+(2013).