• Official Full Name
  • solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
  • Background
  • Mammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity transporters play an important role in the handling of citrate by the kidneys. The protein encoded by this gene represents the high-affinity form. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been characterized yet.
  • Synonyms
  • SLC13A3; solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3; solute carrier family 13 member 3; NADC3; SDCT2; +dicarboxylate cotransporter 3; H sapiens mRNA for hepatocyte nuclear factor 4 gamma; hNaDC3; Na; Na(+)/dicarboxylate cotransporter 3; NaDC 3; NaDC-3; S13A3_HUMAN; SDCT 2; Sodium dependent high affinity dicarboxylate transporter 2; Sodium-dependent high-affinity dicarboxylate transporter 2; OTTHUMP00000031667; OTTHUMP00000214796; OTTHUMP00000214797; OTTHUMP00000214798; sodium-dependent high affinity dicarboxylate transporter 3; sodium-dependent high-affinity dicar
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human SLC13A3 Protein, GST-tagged
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SLC13A3
Source (Host):Species:Human
Product nameRecombinant Human SLC13A3 cell lysate

Involved Pathway

SLC13A3 involved in several pathways and played different roles in them. We selected most pathways SLC13A3 participated on our site, such as SLC-mediated transmembrane transport, Sodium-coupled sulphate, di- and tri-carboxylate transporters, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC13A3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
SLC-mediated transmembrane transport
SLC8A2A; LCN15; SLC6A19B; SLC2A13B; SLC35A3; SLC15A3; SLC6A5; SLC38A4; SLC39A2; SLC39A14
Sodium-coupled sulphate, di- and tri-carboxylate transporters
SLC13A5; SLC13A5A; SLC13A1; SLC13A4; SLC13A3; SLC13A2
Transmembrane transport of small molecules
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
SLC2A15A; SLC2A12; SLC22A16; SLC2A13; SLC5A4; SLC2A8; SLC6A6; RHCG2A; SLC39A14; SLC6A9

Protein Function

SLC13A3 has several biochemical functions, for example, L-aspartate transmembrane transporter activity, citrate transmembrane transporter activity, high-affinity sodium:dicarboxylate symporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC13A3 itself. We selected most functions SLC13A3 had, and list some proteins which have the same functions with SLC13A3. You can find most of the proteins on our site.
Related Protein
Function L-aspartate transmembrane transporter activity
Related Protein SLC25A12; SLC38A7; SLC13A3; SLC1A6; SLC25A13
Function citrate transmembrane transporter activity
Related Protein SLC13A5A; SLC13A3; SLC25A1; SLC13A5; SFXN5
Function high-affinity sodium:dicarboxylate symporter activity
Related Protein SLC13A3
Function sodium:dicarboxylate symporter activity
Related Protein SLC1A2A; SLC1A6; SLC1A2B; SLC1A3; SLC1A7B; SLC1A1; SLC1A5; SLC1A2; SLC1A3A; SLC1A9
Function succinate transmembrane transporter activity
Related Protein SLC13A3; SLC13A5; SLC13A5A