slc3a2
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  • Official Full Name
  • solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
  • Background
  • This gene is a member of the solute carrier family and encodes a cell surface, transmembrane protein. The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. The encoded transporter plays a role in regulation of intracellular calcium levels and transports L-type amino acids. Alternatively spliced transcript variants, encoding different isoforms, have been characterized.
  • Synonyms
  • 4F2; CD98; MDU1; 4F2HC; 4T2HC; NACAE; CD98HC; SLC3A2; 4F2 cell-surface antigen heavy chain; heavy chain; CD98 heavy chain; OTTHUMP00000082735; OTTHUMP00000236708; OTTHUMP00000236709; OTTHUMP00000236712; OTTHUMP00000238367; 4F2 heavy chain antigen Monoclonal 44D7; lymphocyte activation antigen 4F2 large subunit; antigen defined by Monoclonal 4F2, heavy chain; antigen identified by Monoclonal antibodies 4F2, TRA1.10, TROP4, and T43
Cat.#:SLC3A2-949RTag:HlgG1 Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat SLC3A2 Protein (Ala100-Ala527), HlgG1 Fc-tagged
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Cat.#:SLC3A2-229HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human SLC3A2 Protein, His-tagged
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Cat.#:SLC3A2-26956THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human SLC3A2
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Cat.#:SLC3A2-2768HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SLC3A2, His-tagged
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Cat.#:SLC3A2-3960HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human SLC3A2, His tagged
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Cat.#:SLC3A2-587HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human SLC3A2, Fc-tagged, Biotinylated
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Cat.#:SLC3A2-588HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human SLC3A2, Fc-tagged
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Cat.#:Slc3a2-1196MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Slc3a2 protein, His & GST-tagged
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Cat.#:Slc3a2-7031MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Slc3a2, His tagged
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Cat.#:Slc3a2-1197RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Slc3a2 protein, His & GST-tagged
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Cat.#:SLC3A2-5538RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SLC3A2 Protein
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Cat.#:Slc3a2-8781RTag:GST
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Slc3a2, His tagged
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Cat.#:SLC3A2-2015HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human SLC3A2 cell lysate
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Cat.#:SLC3A2-1772MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse SLC3A2 cell lysate
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Cat.#:SLC3A2-1199RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat SLC3A2 cell lysate
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Involved Pathway

SLC3A2 involved in several pathways and played different roles in them. We selected most pathways SLC3A2 participated on our site, such as Protein digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC3A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Protein digestion and absorption
COL10A1; COL6A5; COL6A4; ATP1A4; SLC1A1; PRSS3; SLC8A1; PGA4; ATP1A1; COL6A6

Protein Function

SLC3A2 has several biochemical functions, for example, calcium:sodium antiporter activity, catalytic activity, cation binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC3A2 itself. We selected most functions SLC3A2 had, and list some proteins which have the same functions with SLC3A2. You can find most of the proteins on our site.
Function
Related Protein
Function calcium:sodium antiporter activity
Related Protein SLC8A1; SLC3A2; SLC8A4B; SLC8A2A; SLC24A6; SLC8A2; SLC8A2B; SLC24A4; SLC8A1A; SLC8A4A
Function catalytic activity
Related Protein PKM; ACSL4A; CPS1; RSAD2; PPM1H; RSAD1; DPYDB; ACSL1A; LDHBA; DIP2B
Function cation binding
Related Protein PPM1E; PPM1NB; PPM1BB; PPM1LA; Amy1; PPM1BA; SLC3A1; SLC3A2A; PPM1LB; PPM1DA
Function double-stranded RNA binding
Related Protein HMGB1; VIM; DHX30; STRBP; DDX21; LSM14A; TARBP2; TLR7; AGO2; OASL
Function neutral amino acid transmembrane transporter activity
Related Protein SLC15A1B; SLC38A5; SLC43A2; SLC6A19B; SLC6A19A; SLC43A2A; SLC43A2B; SLC3A2; SLC1A5; SLC43A1A
Function poly(A) RNA binding
Related Protein YTHDC1; EIF1AX; UBE2I; MBNL1; MKI67; SAMD4B; TPT1; KHSRP; HNRPDL; STAU1
Function protein binding
Related Protein CD33; LIMS3L; GZMB; PRKAA1; UFC1; DAP3; UBR1; PTEN; KRTAP23-1; KCTD9

Interacting Protein

SLC3A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC3A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC3A2.
EGFR; PTP4A3; ARF6; TSC22D1; PHB2; BRF2; NEK6; GSTK1; PHLDA3; b3xyc5_sollc; 15-deoxy-delta(12,14; ere_dna; FN1; cona_canen

SLC3A2 Related Articles

El-Mallawany, NK; Day, N; et al. Differential proteomic analysis of endemic and sporadic Epstein-Barr virus-positive and negative Burkitt lymphoma. EUROPEAN JOURNAL OF CANCER 51:92-100(2015).
Estrach, S; Lee, SA; et al. CD98hc (SLC3A2) Loss Protects Against Ras-Driven Tumorigenesis by Modulating Integrin-Mediated Mechanotransduction. CANCER RESEARCH 74:6878-6889(2014).