smad5
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  • Official Full Name
  • SMAD family member 5
  • Background
  • The protein encoded by this gene is involved in the transforming growth factor beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by bone morphogenetic proteins type 1 receptor kinase, and may be involved in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
  • Synonyms
  • SMAD5; SMAD family member 5; DWFC; JV5-1; MADH5; mothers against decapentaplegic homolog 5; SMA- and MAD-related protein 5; SMAD, mothers against DPP homolog 5; MAD, mothers against decapentaplegic homolog 5; mothers against decapentaplegic, drosophila, homolog of, 5;
Cat.#:SMAD5-303HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD5 Protein, His-tagged
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Cat.#:SMAD5-1493HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD Family Member 5, GST-tagged
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Cat.#:SMAD5-162HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD5 Protein, His-tagged
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Cat.#:SMAD5-2800HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD5, GST-tagged
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Cat.#:SMAD5-31194THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD5
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Cat.#:SMAD5-479MTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Smad5, Gly & Pro tagged
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Cat.#:Smad5-8679MTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Smad5, His-GST tagged
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Cat.#:SMAD5-4333RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SMAD5 Protein, His-tagged
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Cat.#:SMAD5-2174CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SMAD5
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Cat.#:SMAD5-8946ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SMAD5
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Cat.#:SMAD5-001MCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse SMAD5 cell lysate
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Involved Pathway

SMAD5 involved in several pathways and played different roles in them. We selected most pathways SMAD5 participated on our site, such as TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
TGF-beta signaling pathway
TGFB2; RBX1; IFNG1-2; ROCK1; AMHR2; TNF; TGIF2; BMP4; NODAL; BMPR2B
Signaling pathways regulating pluripotency of stem cells
SMAD2; NRAS; GSK3B; SMAD9; ID4; MAP2K1; PCGF3; WNT11; ID2; ISL1

Protein Function

SMAD5 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD5 itself. We selected most functions SMAD5 had, and list some proteins which have the same functions with SMAD5. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein GON4L; ZNF189; SOX3; NUSAP1; CDK9; ATRX; NR1I3; ZNF483; PPARA; ZFP521
Function RNA polymerase II core promoter sequence-specific DNA binding
Related Protein SOX8; TP53; ZFP335; SUZ12; TFAP2B; STAT5A; RBPJ; GBX2; SPI1; TAL1
Function metal ion binding
Related Protein SMYD1B; BCL11BA; ZNF789; CYP21A1; ROCK2A; ZNF621; CMC1; AOX4; TSSK5; MOXD2
Function protein binding
Related Protein MBIP; MATN3; LCK; PPP1R12C; IK; PIH1D2; ZNF544; LARP7; ADAM17; TMPRSS4
Function transcription factor activity, sequence-specific DNA binding
Related Protein GTF2H2; VDRB; HDAC1; ZIC5; ZNF471; GLIS2; ZNF202; HOXA5; REST; PLAG1
Function ubiquitin protein ligase binding
Related Protein NLK; C10orf46; ERBB2; TMEM173; UBE2J2; UBE2V1; PRKACA; STUB1; WFS1; ARIH1

SMAD5 Related Articles

Kaneko, K; Higuchi, C; et al. Hyaluronan inhibits BMP-induced osteoblast differentiation. FEBS LETTERS 589:447-454(2015).
Yao, QP; Zhang, P; et al. The role of SIRT6 in the differentiation of vascular smooth muscle cells in response to cyclic strain. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 49:98-104(2014).

SMAD5 Related Gene Family

TGF