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Recombinant Human SMAD5

Cat.No. : SMAD5-31194TH
Product Overview : Recombinant full length human SMAD5 with N-terminal proprietary tag; amino acids 1-465, 82kDa.
  • Specification
  • Gene Information
  • Related Products
Description : The protein encoded by this gene is involved in the TGF-beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by BMP type 1 receptor kinase. Three transcript variants encoding the same protein have been found for this gene.
Source : E. coli
Tissue specificity : Ubiquitous.
Form : Liquid
Storage buffer : Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM PMSF, pH 7.5
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the dwarfin/SMAD family.Contains 1 MH1 (MAD homology 1) domain.Contains 1 MH2 (MAD homology 2) domain.
Gene Name : SMAD5 SMAD family member 5 [ Homo sapiens ]
Official Symbol : SMAD5
Synonyms : SMAD5; SMAD family member 5; MAD, mothers against decapentaplegic homolog 5 (Drosophila) , MADH5, SMAD, mothers against DPP homolog 5 (Drosophila); mothers against decapentaplegic homolog 5; Dwfc; JV5 1;
Gene ID : 4090
mRNA Refseq : NM_001001419
Protein Refseq : NP_001001419
MIM : 603110
Uniprot ID : Q99717
Chromosome Location : 5q31
Pathway : ALK1 signaling events, organism-specific biosystem; ALK2 signaling events, organism-specific biosystem; BMP receptor signaling, organism-specific biosystem; Id Signaling Pathway, organism-specific biosystem; Signal Transduction, organism-specific biosystem;
Function : protein binding; receptor signaling protein activity; sequence-specific DNA binding transcription factor activity; transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity; ubiquitin protein ligase binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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