sord
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  • Official Full Name
  • sorbitol dehydrogenase
  • Background
  • Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 (PubMed 8535074)). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.
  • Synonyms
  • SORD; sorbitol dehydrogenase; L-iditol 2-dehydrogenase; SORD1
Cat.#:SORD-2490HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Sorbitol Dehydrogenase, His-tagged
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Cat.#:SORD-2878HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SORD, His-tagged
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Cat.#:SORD-29HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SORD Protein
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Cat.#:SORD-30012THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SORD, His-tagged
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Cat.#:SORD-15762MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SORD Protein
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Cat.#:SORD-5671RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SORD Protein
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Cat.#:Sord-7045RTag:His|T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Sord protein, His & T7-tagged
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Cat.#:SORD-958CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus SORD Protein, His-tagged
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Cat.#:SORD-4408RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SORD Protein, His-tagged
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Cat.#:SORD-5544CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SORD
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Cat.#:SORD-7683ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SORD
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Cat.#:SORD-7044CTag:His|T7
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle SORD protein, His & T7-tagged
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Cat.#:SORD-1569HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human SORD 293 Cell Lysate
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Involved Pathway

SORD involved in several pathways and played different roles in them. We selected most pathways SORD participated on our site, such as Pentose and glucuronate interconversions, Fructose and mannose metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with SORD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Pentose and glucuronate interconversions
UGT2A2; AKR1B10; DHDH; AKR1B1; OXSR1; UGP2A; DHDHL; ALDH1B1; UGP2B; UGT1A7C
Fructose and mannose metabolism
GMPPAA; HKDC1; ALDOB; PFKFB2A; TIGARB; HK2; PFKFB3; TPI1; ALDOCB; PFKP
Metabolic pathways
HYKK.2; NDUFA1; KDSR; ABP1; GUK1; MDH2; FAXDC2; PAFAH1B1; AMY2A4; DPYD

Protein Function

SORD has several biochemical functions, for example, D-xylulose reductase activity, L-iditol 2-dehydrogenase activity, NAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SORD itself. We selected most functions SORD had, and list some proteins which have the same functions with SORD. You can find most of the proteins on our site.
Function
Related Protein
Function D-xylulose reductase activity
Related Protein SORD
Function L-iditol 2-dehydrogenase activity
Related Protein SORD
Function NAD binding
Related Protein GPD1; IDH3G; CTBP1; BDH2; LDHA; AHCY; CTBP2L; HIBADHB; IDH3B; HPGD
Function carbohydrate binding
Related Protein PRG2; LGALS8; CHI3L1; PVRL1; LGALS9C; PYGM; CNTN1; FCN1; Siglec1; LMAN1L
Function identical protein binding
Related Protein ERBB3; COL2A1; LEPR; EPS15; SSNA1; FHIT; S100A4; PITX2; POU3F2; BNIP3
Function zinc ion binding
Related Protein MARCH2; ZNRD1; TRIM35-23; Car12; SETDB2; MAN2B2; TRIM10; SLC30A8; DYTN; KMT2A

Interacting Protein

SORD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SORD here. Most of them are supplied by our site. Hope this information will be useful for your research of SORD.
GH1; TNIK; RELA; MYH9; ANLN; PDLIM7; CFAP97

SORD Related Articles

Li, TF; Bourgeois, JP; et al. Cell-penetrating anti-GFAP VHH and corresponding fluorescent fusion protein VHH-GFP spontaneously cross the blood-brain barrier and specifically recognize astrocytes: application to brain imaging. FASEB JOURNAL 26:3969-3979(2012).