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SOX4

  • Official Full Name

    SRY (sex determining region Y)-box 4

  • Overview

    SOX genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of SOX genes cluster at a minimum of 40 different loci that rapidly diverged in various animal lineages. At present 30 SOX genes have been identified, and members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal.
  • Synonyms

    SOX4; SRY (sex determining region Y)-box 4; transcription factor SOX-4; SRY-related HMG-box gene 4; ecotropic viral integration site 16; EVI16;

  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Recombinant Proteins
  • Chicken
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SOX4-1559HCL Recombinant Human SOX4 293 Cell Lysate HEK293 N/A
Human SOX4-2077H-B Recombinant Human SOX4 Protein Pre-coupled Magnetic Beads HEK293
Human SOX4-931H Recombinant Human SOX4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SOX4-493HFL Active Recombinant Full Length Human SOX4 Protein, C-Flag-tagged Mammalian cells Flag
Human SOX4-2077H Recombinant Human SOX4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse SOX4-15783M Recombinant Mouse SOX4 Protein Mammalian Cell His
Mouse SOX4-8592M Recombinant Mouse SOX4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse SOX4-8592M-B Recombinant Mouse SOX4 Protein Pre-coupled Magnetic Beads HEK293
Mouse Sox4-6056M Recombinant Mouse Sox4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Sox4-28M Recombinant Mouse Sox4 protein, His-tagged E.coli His Gly194~Tyr440
Chicken SOX4-6054C Recombinant Chicken SOX4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

SOX4 involved in several pathways and played different roles in them. We selected most pathways SOX4 participated on our site, such as MicroRNAs in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with SOX4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MicroRNAs in cancerPIM1;SLC45A3;PDCD4;HDAC1;TTC6;MTOR;APC2;NFKB1;PIK3R2

SOX4 has several biochemical functions, for example, RNA polymerase II transcription coactivator activity, core promoter sequence-specific DNA binding, nucleic acid binding transcription factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SOX4 itself. We selected most functions SOX4 had, and list some proteins which have the same functions with SOX4. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II transcription coactivator activitySMARCA4;SOX11;CREBBP;SMARCA2;TRIM28;MKL1B;CITED2;CITED4;PSIP1
core promoter sequence-specific DNA bindingNFYA;THRAP3;PROX1;SOX4;TP53;H2AFY;SOHLH1;PPARG;NRF1
nucleic acid binding transcription factor activityGATA3;SOX4
protein bindingISY1;ADAMTS13;IST1;GNG5;CXXC11;VHLL;ATP6V1F;ETS2;ARL14
protein heterodimerization activityCENPA;PDSS1;CLCN3;Defa-rs7;HIST1H2BI;HMG20A;MYF6;FLOT2;SMC1A
transcription factor activity, sequence-specific DNA bindingTFDP1;ZNF583;ATF4B1;NFE2L2B;SLC12A9;WT1;NFE2;SOX5;PRRX2
transcription regulatory region sequence-specific DNA bindingARNTL;NFE2L1B;BACH1B;NR5A2;POU2F1;HDAC1;NR5A1B;FOXJ1;ZNF658
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingRFX4;POU4F2;ZSCAN21;AKNA;HEYL;NFIB;NFKB2;JUNB;TCF21

SOX4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOX4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOX4.

GATA3

  • Q&As
  • Reviews

Q&As (6)

Ask a question
How does SOX4 protein interact with other proteins? 06/24/2022

SOX4 proteins may interact with other proteins to fulfill their functions. These interactions can involve various types of protein-protein interactions like electrostatic interactions, hydrogen bonding, etc. Understanding these interactions can help unravel the mechanism of action of SOX4 proteins in cells.

What are the effects of mutations or modifications in the SOX4 protein on organisms? 06/16/2022

Mutations or modifications of the SOX4 protein may affect its function and thus affect the organism. The specific effects may vary depending on the type and location of the mutation or modification and may involve various biological processes, such as growth and development, immune response, etc.

What is the expression pattern of SOX4 protein? 07/01/2021

This protein may be highly expressed in specific tissues and cells and low in other tissues and cells. Its expression pattern may be affected by a variety of factors, including gene regulation, transcription factors, etc.

In which biological processes does SOX4 protein function? 10/27/2020

SOX4 protein may be involved in a variety of biological processes, including sex determination, gonadal development, nervous system development, etc. These processes require the regulatory action of the SOX4 protein for normal development and function.

How to design experiments to study the structure and function of SOX4 protein? 04/15/2020

Studying the structure and function of SOX4 protein may require the design of a series of experiments, including biochemical and cell biology experiments. For example, X-ray crystal diffraction can be used to study its structure, and its function can be studied by gene knockout or knockdown techniques.

How to evaluate the potential of SOX4 protein as a drug target? 04/12/2020

Evaluating the potential of SOX4 protein as a drug target can involve several aspects, including its expression level in organisms, its role in biological processes, and its changes in disease. In addition, factors such as ease of drug development for this protein and potential drug side effects need to be considered. At the same time, in vitro and in vivo experiments can be performed with known SOX4 inhibitors or agonists to verify their efficacy and safety.

Customer Reviews (3)

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Reviews
08/09/2021

    The anti-interference ability in Western blot is very strong, and it can effectively resist the influence of endogenous interference factors.

    09/19/2020

      The ability to maintain stable performance after multiple uses gives me more confidence in the results.

      03/05/2020

        SOX4 has a high safety profile and has no adverse reactions during use.

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