sox4
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  • Official Full Name
  • SRY (sex determining region Y)-box 4
  • Background
  • SOX genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of SOX genes cluster at a minimum of 40 different loci that rapidly diverged in various animal lineages. At present 30 SOX genes have been identified, and members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal.
  • Synonyms
  • SOX4; SRY (sex determining region Y)-box 4; transcription factor SOX-4; SRY-related HMG-box gene 4; ecotropic viral integration site 16; EVI16
Cat.#:SOX4-15783MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SOX4 Protein
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Cat.#:SOX4-6054CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SOX4
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Cat.#:SOX4-1559HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human SOX4 293 Cell Lysate
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Involved Pathway

SOX4 involved in several pathways and played different roles in them. We selected most pathways SOX4 participated on our site, such as MicroRNAs in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with SOX4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MicroRNAs in cancer
SHC1; ABL1; RDX; PDCD4; PIK3R2; EZR; TNN; ERBB2; NFKB1; MAP2K2

Protein Function

SOX4 has several biochemical functions, for example, RNA polymerase II transcription coactivator activity, core promoter sequence-specific DNA binding, nucleic acid binding transcription factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SOX4 itself. We selected most functions SOX4 had, and list some proteins which have the same functions with SOX4. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II transcription coactivator activity
Related Protein ANKRD1; NCOA1; PRRX1; POU3F1; CREBBP; CITED4; MEF2A; RERE; SOX12; TRIM28
Function core promoter sequence-specific DNA binding
Related Protein TOP1; TP53; SOX4; PRMT5; SP1; NRIP1; CRY1; GATA3; MLL1; NR1D2
Function nucleic acid binding transcription factor activity
Related Protein GATA3; SOX4
Function protein binding
Related Protein COMMD6; RAD23B; LAIR1; ATP5G1; DLG3; ZBED1; PCBP2; CASP2; IMMT; OTUB1
Function protein heterodimerization activity
Related Protein CAV1; HIST1H2AI; ITGB1; VEGFB; CHRNB2; PBX1; FZD1; TPD52; GM5506; UNC13A
Function transcription factor activity, sequence-specific DNA binding
Related Protein TWIST2; ZNF43; SMAD3A; ZNF454; ZSCAN2; UBN2B; TSC22D4; MTA2; LHX8A; ZFP27
Function transcription regulatory region sequence-specific DNA binding
Related Protein KDM3A; TFAP2A; BACH1B; SOX4; NFE2L1B; MEF2CA; EGR1; NR5A5; NONO; SOX12
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein BCL11B; MEF2A; BARHL2; CARF; SOX12; SIX2; HOXA7; MAFA; NFIA; MEOX2

Interacting Protein

SOX4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOX4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOX4.
GATA3