SOX4
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Official Full Name
SRY (sex determining region Y)-box 4
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Overview
SOX genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of SOX genes cluster at a minimum of 40 different loci that rapidly diverged in various animal lineages. At present 30 SOX genes have been identified, and members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal. -
Synonyms
SOX4; SRY (sex determining region Y)-box 4; transcription factor SOX-4; SRY-related HMG-box gene 4; ecotropic viral integration site 16; EVI16;
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Recombinant Proteins
- Chicken
- Human
- Mouse
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Flag
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | SOX4-1559HCL | Recombinant Human SOX4 293 Cell Lysate | HEK293 | N/A | ||
Human | SOX4-2077H-B | Recombinant Human SOX4 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Human | SOX4-931H | Recombinant Human SOX4 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK | ||
Human | SOX4-493HFL | Active Recombinant Full Length Human SOX4 Protein, C-Flag-tagged | Mammalian cells | Flag | ||
Human | SOX4-2077H | Recombinant Human SOX4 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | SOX4-15783M | Recombinant Mouse SOX4 Protein | Mammalian Cell | His | ||
Mouse | SOX4-8592M | Recombinant Mouse SOX4 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | SOX4-8592M-B | Recombinant Mouse SOX4 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | Sox4-6056M | Recombinant Mouse Sox4 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK | ||
Mouse | Sox4-28M | Recombinant Mouse Sox4 protein, His-tagged | E.coli | His | Gly194~Tyr440 | |
Chicken | SOX4-6054C | Recombinant Chicken SOX4 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
SOX4 involved in several pathways and played different roles in them. We selected most pathways SOX4 participated on our site, such as MicroRNAs in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with SOX4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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MicroRNAs in cancer | PIM1;SLC45A3;PDCD4;HDAC1;TTC6;MTOR;APC2;NFKB1;PIK3R2 |
SOX4 has several biochemical functions, for example, RNA polymerase II transcription coactivator activity, core promoter sequence-specific DNA binding, nucleic acid binding transcription factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SOX4 itself. We selected most functions SOX4 had, and list some proteins which have the same functions with SOX4. You can find most of the proteins on our site.
Function | Related Protein |
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RNA polymerase II transcription coactivator activity | SMARCA4;SOX11;CREBBP;SMARCA2;TRIM28;MKL1B;CITED2;CITED4;PSIP1 |
core promoter sequence-specific DNA binding | NFYA;THRAP3;PROX1;SOX4;TP53;H2AFY;SOHLH1;PPARG;NRF1 |
nucleic acid binding transcription factor activity | GATA3;SOX4 |
protein binding | ISY1;ADAMTS13;IST1;GNG5;CXXC11;VHLL;ATP6V1F;ETS2;ARL14 |
protein heterodimerization activity | CENPA;PDSS1;CLCN3;Defa-rs7;HIST1H2BI;HMG20A;MYF6;FLOT2;SMC1A |
transcription factor activity, sequence-specific DNA binding | TFDP1;ZNF583;ATF4B1;NFE2L2B;SLC12A9;WT1;NFE2;SOX5;PRRX2 |
transcription regulatory region sequence-specific DNA binding | ARNTL;NFE2L1B;BACH1B;NR5A2;POU2F1;HDAC1;NR5A1B;FOXJ1;ZNF658 |
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | RFX4;POU4F2;ZSCAN21;AKNA;HEYL;NFIB;NFKB2;JUNB;TCF21 |
SOX4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOX4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOX4.
GATA3
- Q&As
- Reviews
Q&As (6)
Ask a questionSOX4 proteins may interact with other proteins to fulfill their functions. These interactions can involve various types of protein-protein interactions like electrostatic interactions, hydrogen bonding, etc. Understanding these interactions can help unravel the mechanism of action of SOX4 proteins in cells.
Mutations or modifications of the SOX4 protein may affect its function and thus affect the organism. The specific effects may vary depending on the type and location of the mutation or modification and may involve various biological processes, such as growth and development, immune response, etc.
This protein may be highly expressed in specific tissues and cells and low in other tissues and cells. Its expression pattern may be affected by a variety of factors, including gene regulation, transcription factors, etc.
SOX4 protein may be involved in a variety of biological processes, including sex determination, gonadal development, nervous system development, etc. These processes require the regulatory action of the SOX4 protein for normal development and function.
Studying the structure and function of SOX4 protein may require the design of a series of experiments, including biochemical and cell biology experiments. For example, X-ray crystal diffraction can be used to study its structure, and its function can be studied by gene knockout or knockdown techniques.
Evaluating the potential of SOX4 protein as a drug target can involve several aspects, including its expression level in organisms, its role in biological processes, and its changes in disease. In addition, factors such as ease of drug development for this protein and potential drug side effects need to be considered. At the same time, in vitro and in vivo experiments can be performed with known SOX4 inhibitors or agonists to verify their efficacy and safety.
Customer Reviews (3)
Write a reviewThe anti-interference ability in Western blot is very strong, and it can effectively resist the influence of endogenous interference factors.
The ability to maintain stable performance after multiple uses gives me more confidence in the results.
SOX4 has a high safety profile and has no adverse reactions during use.
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