stat6
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  • Official Full Name
  • signal transducer and activator of transcription 6, interleukin-4 induced
  • Background
  • The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
  • Synonyms
  • STAT6; signal transducer and activator of transcription 6, interleukin-4 induced; STAT6B; STAT6C; D12S1644; IL-4-STAT; signal transducer and activator of transcription 6; STAT, interleukin4-induced; transcription factor IL-4 STAT;
Cat.#:STAT6-2897HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human STAT6 Protein, MYC/DDK-tagged
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Cat.#:STAT6-30854THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STAT6, His-tagged
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Cat.#:STAT6-344HTag:His|MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STAT6 protein, His/MBP-tagged
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Cat.#:STAT6-4889HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Signal Transducer And Activator Of Transcription 6, GST-tagged
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Cat.#:STAT6-7039HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human STAT6, His tagged
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Cat.#:STAT6-707HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STAT6 Protein, His-tagged
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Cat.#:STAT6-16113MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse STAT6 Protein
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Cat.#:Stat6-1731MTag:His|T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Stat6 protein, His & T7-tagged
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Cat.#:Stat6-1732RTag:His|T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Stat6 protein, His & T7-tagged
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Cat.#:STAT6-4519RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey STAT6 Protein, His-tagged
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Cat.#:STAT6-7074ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish STAT6
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Cat.#:STAT6-481HCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human STAT6 cell lysate
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Involved Pathway

STAT6 involved in several pathways and played different roles in them. We selected most pathways STAT6 participated on our site, such as Jak-STAT signaling pathway, Hepatitis B, Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with STAT6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Jak-STAT signaling pathway
RNF207B; STAT3; IL15; IFNA21; IL-15RA; BCL2A; PTPN2A; IL22RA2; CRFB4; GRB2
Hepatitis B
STAT6; STAT2; HBXIP; IKBKE; PTK2B; IFNA12; CASP12; IFNA14; DDB2; TGFB3
Inflammatory bowel disease (IBD)
IL17A; H2-AA; HLA-DQA1; TNF; IL6; IFNG; IL1B; IL18R1; TLR4; IL23

Protein Function

STAT6 has several biochemical functions, for example, RNA polymerase II core promoter sequence-specific DNA binding, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STAT6 itself. We selected most functions STAT6 had, and list some proteins which have the same functions with STAT6. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II core promoter sequence-specific DNA binding
Related Protein GATA3; ZFPM1; H3F3A; ZNF335; SOX8; TFAP2A; SMYD3; GBX2; HOXB3; TBR1
Function identical protein binding
Related Protein KHDC1A; HSP90AA1; INS; DAAM1; EPS15; ANXA4; NFKB1; DRD2; TTR; NOXO1
Function protein binding
Related Protein PDLIM2; PRLHR; OIT3; DVL1; RNF4; SUV420H2; TSSK6; SPSB4; SRA1; COPS7A
Function protein phosphatase binding
Related Protein MAP2K7; VRK3; PIK3R1; LCK; EGFR; CDH5; KAT2A; TRAF3; SHOC2; CDC27
Function signal transducer activity
Related Protein ATP2C1; PRLH2R; PTK2; OLFCD2; GPR184; TAAR7A; GPR34A; VMN1R43; IL11RA; DKKL1
Function transcription factor activity, sequence-specific DNA binding
Related Protein SS18L1; ZFP110; ZGPAT; ZFP36L1; TAL1; NR1I3; ZHX2; ZFP13; SOX2; RXRGA

Interacting Protein

STAT6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STAT6 here. Most of them are supplied by our site. Hope this information will be useful for your research of STAT6.
IL4R; TMEM173; TBK1

STAT6 Related Articles

van Slambrouck, C; Huh, J; et al. Nuclear Staining for Stat6 With the YE361 Monoclonal Antibody Is Restricted To Classical Hodgkin Lymphoma. MODERN PATHOLOGY 28:382A-383A(2015).
van Slambrouck, C; Huh, J; et al. Nuclear Staining for Stat6 With the YE361 Monoclonal Antibody Is Restricted To Classical Hodgkin Lymphoma. LABORATORY INVESTIGATION 95:382A-383A(2015).

STAT6 Related Gene Family

Cytokines