Recombinant Full Length Human STAT6 Protein, C-Flag-tagged

• Cat.No.: STAT6-888HFL
• Product Overview: Recombinant Full Length Human STAT6 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 94 kDa
• AA Sequence: MSLWGLVSKMPPEKVQRLYVDFPQH LRHLLGDWLESQPWEFLVGSDAFCC NLTSALLSDTVQHLQASVG EQGEGSTILQHISTLESIYQRDPLK LVATFRQILQGEKKAVMEQFRHLPM PFHWKQEELKFKTGLRRLQ HRVGEIHLLREALQKGAEAGQVSLH SLIETPANGTGPSEALAMLLQETTG ELEAAKALVLKRIQIWKRQ QQLAGNGAPFEESLAPLQERCESLV DIYSQLQQEVGAAGGELEPKTRASL TGRLDEVLRTLVTSCFLVE KQPPQVLKTQTKFQAGVRFLLGLRF LGAPAKPPLVRADMVTEKQARELSV PQGPGAGAESTGEIINNTV PLENSIPGNCCSALFKNLLLKKIKR CERKGTESVTEEKCAVLFSASFTLG PGKLPIQLQALSLPLVVIV HGNQDNNAKATILWDNAFSEMDRVP FVVAERVPWEKMCETLNLKFMAEVG TNRGLLPEHFLFLAQKIFN DNSLSMEAFQHRSVSWSQFNKEILL GRGFTFWQWFDGVLDLTKRCLRSYW SDRLIIGFISKQYVTSLLL NEPDGTFLLRFSDSEIGGITIAHVI RGQDGSPQIENIQPFSAKDLSIRSL GDRIRDLAQLKNLYPKKPK DEAFRSHYKPEQMGKDGRGYVPATI KMTVERDQPLPTPELQMPTMVPSYD LGMAPDSSMSMQLGPDMVP QVYPPHSHSIPPYQGLSPEESVNVL SAFQEPHLQMPPSLGQMSLPFDQPH PQGLLPCQPQEHAVSSPDP LLCSDVTMVEDSCLSQPVTAFPQGT WIGEDIFPPLLPPTEQDLTKLLLEG QGESGGGSLGAQPLLQPSH
  YGQSGISMSHMDLRANLSWTRTRPL EQKLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Stem cell relevant signaling - DSL/Notch pathway, Stem cell relevant signaling - JAK/STAT signaling pathway, Transcription Factors
• Protein Pathways: Jak-STAT signaling pathway

Gene Information

• Gene Name: STAT6 signal transducer and activator of transcription 6 [ Homo sapiens (human) ]
• Official Symbol: STAT6
• Synonyms: STAT6B; STAT6C; D12S1644; IL-4-STAT
• Gene ID: 6778
• mRNA Refseq: NM_003153.5
• Protein Refseq: NP_003144.3
• MIM: 601512
• UniProt ID: P42226