| Official Full Name | serine/threonine kinase 10 |
| Background | This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. |
| Synonyms | STK10; serine/threonine kinase 10; serine/threonine-protein kinase 10; LOK; PRO2729; lymphocyte-oriented kinase |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|
STK10 involved in several pathways and played different roles in them. We selected most pathways STK10 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with STK10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
STK10 has several biochemical functions, for example, ATP binding, identical protein binding, polo kinase kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by STK10 itself. We selected most functions STK10 had, and list some proteins which have the same functions with STK10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | GRK1; JAK1; NLRP4C; ABCA4; GARS; MYO3B; MCM8; SGK2; BAT1; PAPOLA |
| identical protein binding | RASSF1; SKP2; TLE1; SOX10; PFKM; SNCA; SNRNP200; APAF1; ACTN2; PLN |
| polo kinase kinase activity | STK10 |
| protein binding | TCF7L1A; TMPO; DCDC2B; SYVN1; KLF15; TSC1; CNKSR3; KAT5; TSC22D1; AP3M1 |
| protein homodimerization activity | RENBP; ENPP1; ATP2A1; SPPL2B; HARS2; VOX; PYGB; SNX1; CHUK; TWIST1 |
| protein serine/threonine kinase activity | UHMK1; NEK5; MAP4K3; NIM1K; ERN1; KALRN; CSNK1DB; SBK1; SRPK2; PLK4 |
STK10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STK10 here. Most of them are supplied by our site. Hope this information will be useful for your research of STK10.
abl-tide; midostaurin
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