stk4
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  • Official Full Name
  • serine/threonine kinase 4
  • Background
  • The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and its possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008]
  • Synonyms
  • STK4; serine/threonine kinase 4; KRS2; MST1; YSK3; TIIAC; serine/threonine-protein kinase 4; MST-1; STE20-like kinase MST1; mammalian sterile 20-like 1; kinase responsive to stress 2; mammalian STE20-like protein kinase 1; serine/threonine-protein kinase Krs-2; dJ211D12.2 (serine/threonine kinase 4 (MST1, KRS2));
Cat.#:STK4-2960HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human STK4 Protein, MYC/DDK-tagged
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Cat.#:STK4-30251THTag:
Source (Host):Species:Human
Product nameRecombinant Human STK4
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Cat.#:STK4-361HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Serine/Threonine Kinase 4, GST-tagged, Active
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Cat.#:STK4-954HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human STK4, His tagged
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Cat.#:STK4-4530RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey STK4 Protein, His-tagged
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Cat.#:STK4-2548CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken STK4
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Cat.#:STK4-709HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Serine/Threonine Kinase 4, GST-His
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Cat.#:STK4-604HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human STK4 cell lysate
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Involved Pathway

STK4 involved in several pathways and played different roles in them. We selected most pathways STK4 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with STK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
Pdgfa&Pdgfb; ARRB2A; MYCB; NLK1; MAPK12; MAPKAPK3; NTRK2B; HSP70; Fasl; TRP53
Ras signaling pathway
FLT1; Kitl; MLLT4; FASLG; HGF; NRAS; PIK3R2; MAPK1; PLCG2; GRIN2A
FoxO signaling pathway
AKT2; CDKN1BA; SGK1; MDM2; PIK3R3A; BRAF; CCNB3; PLK2; SGK2B; ARAF
Pathways in cancer
APPL1; PDGFRB; RAC1; BIRC2; GNAI1; BMP4; BAD; PTK2; FLT3LG; PLCB1
Non-small cell lung cancer
FHIT; MAP2K1; RXRA; TP53; RXRB; BAD; PIK3CG; PIK3R2; MAP2K2; PIK3R1

Protein Function

STK4 has several biochemical functions, for example, ATP binding, MAP kinase kinase kinase activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STK4 itself. We selected most functions STK4 had, and list some proteins which have the same functions with STK4. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein UBE2B; FAM20B; MYH11A; ATP1A1A.2; VARS; GM711; ALK; STK30; ITGB1BP3; MAPK9
Function MAP kinase kinase kinase activity
Related Protein MAP3K14; MAP3K13; TAOK3; RAF1; MAP3K6; STK4; EGFR; TAOK1; STK3; TAOK2
Function identical protein binding
Related Protein DYNLT1; CLDN15; AMOTL2; APOA1; DES; DAPK3; MSTN; ACTN2; APP; IGF1R
Function magnesium ion binding
Related Protein CDC42BPG; SIK2; CIB4; PGM3; PPM1BA; FEN1; STK36; ATP8B1; ENO1; PPA1A
Function protein binding
Related Protein CD2BP2; CTAGE5; ANGPTL4; POGZ; EIF4EBP1; FAF2; KIF18A; ZNF256; FBP1; BEX1
Function protein dimerization activity
Related Protein NEUROD4; ARNTL1A; MITF; SIM1; CELSR1; HES2.2; MEF2AA; STK3; HES6; POLR1D
Function protein homodimerization activity
Related Protein ABCB9; SLC24A6; MAFA; GSS; GPD1B; JUP; ANG; PDCD10; CTSE; ADAM10
Function protein kinase activity
Related Protein PAK2; MAP3K5; TNIKB; DYRK1B; MAPK12A; SMOK2B; ZNF143B; MOK; SRPK1; JAK2B
Function protein serine/threonine kinase activator activity
Related Protein LTF; PARP16; CALM1; STK4; ALS2; STK3; IGF2; CALM3; CDK5R1; MAP2K2
Function protein serine/threonine kinase activity
Related Protein TNIK; CPNE3; ATM; GM711; IRAK2; LIMK1; DCAMKL2; SLC14A2; BUB1B; CAMK1DA
Function transcription factor binding
Related Protein TWIST1; ENPP2; SIRT1; MYOCD; PYDC3; PIAS1; RARA; GCM1; NIF3L1; FOXA2

Interacting Protein

STK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of STK4.
SAV1; RASSF2