TBK1

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TBK1

Official Full Name TANK-binding kinase 1
Background TBK, also known as IkappaB kinase (IKK)-related kinase NAK, belong to the serine/threonine IKK kinase family and is thought to play a role in NF-kappa-B (NF-kappaB) activation. The NF-kappaB complex of proteins is inhibited by I-kappa-B (IKB) proteins,Which inactivate NF-kappaB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NF-kappaB activation in response to certain growth factors. For example, the protein can form a complex with the IKB protein TANK and TRAF2 and release the NF-kappaB inhibition caused by TANK.
Synonyms TBK1; TANK-binding kinase 1; serine/threonine-protein kinase TBK1; NAK; NF-kB-activating kinase; NF-kappa-B-activating kinase; T2K; FLJ11330
    • Species :
    • Chicken
    • Human
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TBK1-1493H Recombinant Human TBK1 (Active), GST-tagged Sf9 Insect Cell GST
    Human TBK1-1745HCL Recombinant Human TBK1 cell lysate N/A
    Human TBK1-27920TH Recombinant Human TBK1 N/A
    Human TBK1-334H Recombinant Human TBK1 protein, GST-tagged Wheat Germ GST
    Human TBK1-335H Recombinant Human TBK1 protein, GST-tagged Wheat Germ GST
    Human TBK1-336H Recombinant Human TBK1 protein, GST-tagged E.coli GST
    Human TBK1-337H Recombinant Human TBK1 protein, His-tagged E.coli His
    Human TBK1-443H Recombinant Human TANK-binding Kinase 1, GST-tagged, Active Sf9 Insect Cell GST
    Human TBK1-657H Recombinant Human TBK1 Protein, His-tagged E.coli His
    Human TBK1-732H Recombinant Human TANK-binding Kinase 1 Sf9 Insect Cell N/A
    Rhesus Macaque TBK1-4642R Recombinant Rhesus monkey TBK1 Protein, His-tagged Mammalian Cell His
    Chicken TBK1-4388C Recombinant Chicken TBK1 Mammalian Cell His
    Zebrafish TBK1-3904Z Recombinant Zebrafish TBK1 Mammalian Cell His

    TBK1 involved in several pathways and played different roles in them. We selected most pathways TBK1 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with TBK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ras signaling pathway GNG2; RAF1; FGF22; RASSF1; INS2; PDGFB; MAPK1; FGFR2; LAT; FGF20
    Toll-like receptor signaling pathway MAPK10; TMED7-TICAM2; IRF3; LY96; TLR4BB; CRFB2; IL12B; MAP2K1; CCL4; MAPK11
    RIG-I-like receptor signaling pathway IFNA16; IL12B; MAPK10; TP-1; IFNA2; PIN1; IFNA7; MAPK9; NFKBIA; OTUD5
    Cytosolic DNA-sensing pathway TMEM173; NFKBIAB; IFNA10; RIPK3; IKBKB; NFKBIAA; POLR1D; AIM2; POLR3GLB; POLR3H
    Hepatitis C LDLR; CLDN14; TBK1; OCLN; CLDN16; IFN-a; IFNA16; PIK3CA; IKBKG; PIK3R2
    Hepatitis B SMAD3; KRAS; FASLG; STAT5B; ATF4; Fasl; DDB2; IKBKG; CREB3L3; IFNA4
    Measles OAS3; CCND2; STAT5B; CD3G; EIF3H; FCGR2B; DDX58; IL6; TP53; OAS1A
    Influenza A RSAD2; OAS1; Fasl; CXCL10; GSK3B; TLR4; NFKBIB; IRF7; BLB1; IFNA4
    Herpes simplex infection ALYREF; MHC1UXA2; EIF2S1B; THOC4; NFKBIA; IFNA7; IKBKB; C3; CD74A; BLB2
    Epstein-Barr virus infection POLR3H; NFKB1; PSMC2; NEDD4; PLCG2; HLA-DQA2; YWHAB; MAPK10; RELA; IRAK1

    TBK1 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by TBK1 itself. We selected most functions TBK1 had, and list some proteins which have the same functions with TBK1. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding CHD2; APAF1; ALPK1; PFKP; HKDC1; PRKD1; MAPK14; P2RX5; INO80; GTF2F2B
    nucleic acid binding ZCCHC10; DBF4B; ZEB2; ZFY1; KLF14; EIF3BA; TRNAU1APB; POLN; HNRNPL2; CELF3A
    phosphoprotein binding DPYS; MS4A2; ARR3; FKBP4; PAFAH1B1; SFN; RB1; YWHAE; SAG; TBK1
    protein binding KIF1C; SCNM1; MRPL48; LGI4; FNTA; PCSK5; FBXW7; HADHA; TTC32; ASCC3
    protein kinase activity BMPR2A; PDPK1A; ERBB4A; CDKL2; BMPR1BA; RIPK1L; STK17B; DYRK1B; PHKG1A; STK25B
    protein serine/threonine kinase activity CSNK1E; MAP3K14; TSSK4; STK38; PHKG1B; NUAK1; PIK3CA; PAK7; CSNK1D; CAMK1GA

    TBK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TBK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TBK1.

    TANK; IRF3; TBKBP1

    Olagnier, D; Scholte, FEM; et al. Inhibition of Dengue and Chikungunya Virus Infections by RIG-I-Mediated Type I Interferon-Independent Stimulation of the Innate Antiviral Response. JOURNAL OF VIROLOGY 88:4180-4194(2014).
    Suzuki, T; Oshiumi, H; et al. Cell Type-Specific Subcellular Localization of Phospho-TBK1 in Response to Cytoplasmic Viral DNA. PLOS ONE 8:-(2013).

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