tbk1
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  • Official Full Name
  • TANK-binding kinase 1
  • Background
  • TBK, also known as IkappaB kinase (IKK)-related kinase NAK, belong to the serine/threonine IKK kinase family and is thought to play a role in NF-kappa-B (NF-kappaB) activation. The NF-kappaB complex of proteins is inhibited by I-kappa-B (IKB) proteins,Which inactivate NF-kappaB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NF-kappaB activation in response to certain growth factors. For example, the protein can form a complex with the IKB protein TANK and TRAF2 and release the NF-kappaB inhibition caused by TANK.
  • Synonyms
  • TBK1; TANK-binding kinase 1; serine/threonine-protein kinase TBK1; NAK; NF-kB-activating kinase; NF-kappa-B-activating kinase; T2K; FLJ11330
Cat.#:TBK1-657HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TBK1 Protein, His-tagged
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Cat.#:TBK1-443HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human TANK-binding Kinase 1, GST-tagged, Active
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Cat.#:TBK1-732HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human TANK-binding Kinase 1
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Cat.#:TBK1-27920THTag:
Source (Host):Species:Human
Product nameRecombinant Human TBK1
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Cat.#:TBK1-334HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human TBK1 protein, GST-tagged
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Cat.#:TBK1-335HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human TBK1 protein, GST-tagged
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Cat.#:TBK1-336HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TBK1 protein, GST-tagged
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Cat.#:TBK1-337HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TBK1 protein, His-tagged
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Cat.#:TBK1-4642RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey TBK1 Protein, His-tagged
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Cat.#:TBK1-4388CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TBK1
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Cat.#:TBK1-3904ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TBK1
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Cat.#:TBK1-1493HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human TBK1 (Active), GST-tagged
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Cat.#:TBK1-1745HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TBK1 cell lysate
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Involved Pathway

TBK1 involved in several pathways and played different roles in them. We selected most pathways TBK1 participated on our site, such as Ras signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TBK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ras signaling pathway
GNB4; Fasl; ANGPT2; PAK6; GNG12; PLCG2; RALBP1; FASLG; RAF1; PIK3R2
Toll-like receptor signaling pathway
CXCL11; MYD88; PIK3CG; TLR7; MAPK14A; PIK3CA; CD86; STAT1; IL12B; IL-8
RIG-I-like receptor signaling pathway
IFNA3; MAPK12B; IFNB; IFNE; Ifna15; IL12BA; IRF7; IKBKG; IFNA7; IFNA21
Cytosolic DNA-sensing pathway
MB21D1; POLR2F; RELA; POLR3E; IRF3; POLR2EB; IFNA5; IFNA16; OSTN; IFNA14
Hepatitis C
TRAF2; PPP2R2B; IL-8; IFNA17; OCLN; TYK2; PIK3CG; PPP2CA; PIK3CA; IFNA12
Hepatitis B
PIK3R1; DDB2; TP53; HSPG2; PIK3CA; TLR3; STAT6; ATP6AP1; MAPK1; TGFB3
Measles
CLEC4M; TRP53; IFNA1; CCND1; IFNB1; FCGR2B; Cd209g; SLAMF1; IL2RG; TLR2
Influenza A
HLA-DMB; MAP2K1; HLA-DPB1; IL12B; NFKBIB; IFNA5; PRSS2; NUP98; IFNA21; TNFRSF10B
Herpes simplex infection
TAB2; PTPN11A; IKBKE; TBP; SRSF7B; CFP; NXF1; PPP1CA; PILRA; C3A.1
Epstein-Barr virus infection
HLA-DRA; MAPK10; TNFAIP3; TAB1; POLR3GL; PSMD8; PRKACG; TRAF5; GTF2E2; IKBKG

Protein Function

TBK1 has several biochemical functions, for example, ATP binding, nucleic acid binding, phosphoprotein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TBK1 itself. We selected most functions TBK1 had, and list some proteins which have the same functions with TBK1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein DYRK1A; ABCA8; PRKCE; NAIP7; ABCA6; ATP9B; PRKAG2; PIF1; DYNC1LI1; PDGFRA
Function nucleic acid binding
Related Protein ZNF292A; CMTR1; FTSJD2; BLM; CHD4A; ZNF576.2; RNASE9; ZEB2A; CIZ1B; ZFP14
Function phosphoprotein binding
Related Protein SAG; PKD2; PITX2; RRAGA; YWHAB; RB1; DPYSL3; PLAT; MTOR; CBX4
Function protein binding
Related Protein ZC3H12A; DARS; LIMD2; FYB; SWSAP1; MCM8; ZZZ3; RNF135; UVRAG; ARAF
Function protein kinase activity
Related Protein FYNA; CCL8; LTK; MAPKAPK2B; LMTK3; MAP3K11; CAMKK1B; SMOK2B; EPHB4A; SOX9
Function protein serine/threonine kinase activity
Related Protein NLK2; GM4922; MAP3K2; MTOR; CHEK1; PHKG2; GM7168; BUB1B; TGFBR1B; ERN1

Interacting Protein

TBK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TBK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TBK1.
TANK; IRF3; TBKBP1

TBK1 Related Articles

Olagnier, D; Scholte, FEM; et al. Inhibition of Dengue and Chikungunya Virus Infections by RIG-I-Mediated Type I Interferon-Independent Stimulation of the Innate Antiviral Response. JOURNAL OF VIROLOGY 88:4180-4194(2014).
Suzuki, T; Oshiumi, H; et al. Cell Type-Specific Subcellular Localization of Phospho-TBK1 in Response to Cytoplasmic Viral DNA. PLOS ONE 8:-(2013).