Recombinant Human TBK1 Protein, His-tagged TBK1-657H

Cat.No.:	TBK1-657H
Product Overview:	Recombinant Human TBK1(Trp9~Val310) fused with His tag at N-terminal was expressed in E. coli.
Description:	The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors.
Source:	E. coli
Species:	Human
Tag :	His
Form:	PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Molecular Mass:	37.9kDa
Protein length:	Trp9~Val310
Endotoxin:	<1.0EU per 1µg (determined by the LAL method)
Purity:	> 90%
Applications:	Positive Control; Immunogen; SDS-PAGE; WB. If bio-activity of the protein is needed, please check active protein.
Stability:	The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage:	Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Reconstitution:	Reconstitute in PBS or others.

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Gene Name:	TBK1 TANK-binding kinase 1 [ Homo sapiens ]
Official Symbol:	TBK1
Synonyms:	TBK1; TANK-binding kinase 1; serine/threonine-protein kinase TBK1; NAK; NF-kB-activating kinase; NF-kappa-B-activating kinase; T2K; FLJ11330;
Gene ID:	29110
mRNA Refseq:	NM_013254
Protein Refseq:	NP_037386
MIM:	604834
UniProt ID:	Q9UHD2