Active Recombinant Mouse Tbk1 Protein, GST-tagged

• Cat.No.: Tbk1-6316M
• Product Overview: Recombinant full-length mouse TBK1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Description: Enables several functions, including identical protein binding activity; protein phosphatase binding activity; and protein serine/threonine kinase activity. Involved in negative regulation of gene expression; peptidyl-serine phosphorylation; and positive regulation of defense response. Acts upstream of or within several processes, including defense response to Gram-positive bacterium; dendritic cell proliferation; and positive regulation of interferon-beta production. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in brain disease and frontotemporal dementia and/or amyotrophic lateral sclerosis-4. Orthologous to human TBK1 (TANK binding kinase 1).
• Source: Insect Cells
• Species: Mouse
• Tag: GST
• Bio-activity: 286.5 nmol/min/mg
• Molecular Mass: 105 kDa
• Purity: > 85%
• Stability: 1 year at -70 centigrade from date of shipment.
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.1 μg/μL
• Storage Buffer: 50 mM Tris-HCI, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, and 25% glycerol.
• Shipping: Dry ice.

Gene Information

• Gene Name: Tbk1 TANK-binding kinase 1 [ Mus musculus (house mouse) ]
• Official Symbol: Tbk1
• Synonyms: Tbk1; TANK-binding kinase 1; 1200008B05Rik; serine/threonine-protein kinase TBK1; T2K; EC 2.7.11.1
• Gene ID: 56480
• mRNA Refseq: NM_019786
• Protein Refseq: NP_062760
• UniProt ID: A1L361