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TG

  • Official Full Name

    thyroglobulin

  • Overview

    Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis.
  • Synonyms

    TG; thyroglobulin; TGN; AITD3; Thyroglobulin; Tg;

  • Recombinant Proteins
  • Native Proteins
  • Transfected Stable Cell Lines
  • Protein Pre-coupled Magnetic Beads
  • Others
  • Assay Kits
  • Bovine
  • Human
  • Mouse
  • Pig
  • Porcine
  • Rat
  • Bovine Thyroid
  • E. coli
  • E.coli
  • HEK293
  • HEK293 cells
  • HEK293T
  • Human
  • Human Thyroids
  • Mammalian Cell
  • Pig
  • Porcine
  • Porcine thyroid gland
  • Wheat Germ
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • His|SUMO
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TG-8267H Recombinant Human TG, GST-tagged Wheat Germ GST
Human TG-8266H Recombinant Human TG, GST-tagged Wheat Germ GST
Human TG-499H Recombinant Human TG Protein, His-tagged E.coli His Ser2083~Ala2333
Human TG-3207H Recombinant Human TG, GST-tagged E.coli GST C-347aa
Human TG-4645H Thyroglobulin(Human) Human N/A
Human TG-31519TH Native Human TG N/A 2749 amino acids
Human TG-4H Human Thyroglobulin (Tg) Reference Standard N/A
Human TG-6336H Recombinant Human TG Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human TG-8265H Native Human Thyroids Thyroglobulin Human Thyroids N/A
Human TG-393H Native Human Thyroglobulin Human Thyroids N/A
Human TG-0056H Recombinant Human TG Protein HEK293 cells
Human TG-708H Recombinant Human TG Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human TG-2515H Recombinant Human TG protein(1511-1610 aa), C-His-tagged E. coli C-His 1511-1610 aa
Mouse Tg-500M Recombinant Mouse Tg Protein, His-tagged E.coli His Ser2418~Asn2660
Mouse TG-16699M Recombinant Mouse TG Protein Mammalian Cell His
Mouse TG-9158M-B Recombinant Mouse TG Protein Pre-coupled Magnetic Beads HEK293
Mouse Tg-6386M Recombinant Mouse Tg Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse TG-9158M Recombinant Mouse TG Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat TG-2112R Recombinant Rat TG Protein (21-300 aa), His-SUMO-tagged E.coli His/SUMO 21-300 aa
Rat Tg-2125R Recombinant Rat Tg Protein, His-tagged E.coli N-His Cys1150-Cys1509
Bovine TG-121B Native Bovine TG Bovine Thyroid N/A
Porcine TG-37P Native Porcine TG protein Porcine thyroid gland N/A
Porcine TG-22P Native Porcine Thyroglobulin (TG) Protein Porcine N/A
Pig TG-337PI Immobilized Pig TG protein Pig N/A
Kit-0814 Transglutaminase Activity Colorimetric Assay Kit N/A
Kit-2277 Transglutaminase Inhibitor Screening Assay Kit N/A
Kit-0815 Triglyceride Quantification Kit N/A
Kit-2036 Triglyceride Colorimetric Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TG Related Articles

TG involved in several pathways and played different roles in them. We selected most pathways TG participated on our site, such as Thyroid hormone synthesis, Autoi, ne thyroid disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with TG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Thyroid hormone synthesisITPR1;CREB3L1;TSHR;ATP1B2;GPX2;ATP1B4;ASGR1;Adcy4;GPX6
AutoiFASLG;HLA-DPB1;IFNA5;H2-AB1;HLA-C;IFNA2;CD80;GZMB;HLA-DQB1
ne thyroid diseaseIL4;IFNA17;IFNA12;H2-AB1;GZMB;IFNA1;IFNA13;CD28;HLA-DOB

TG has several biochemical functions, for example, anion binding, chaperone binding, hormone activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TG itself. We selected most functions TG had, and list some proteins which have the same functions with TG. You can find most of the proteins on our site.

Function Related Protein
anion binding
chaperone bindingCP;CLU;GRPEL2;BAG1;TFRC;DNAJA4;DNAJA2L;CDKN1B;SDF2L1
hormone activityC19orf80;INSL5;GUCA2A;PTH1A;INSL4;VIP;FSHB;IGF1;IGF2A
protein complex bindingRAP1A;RNF40;LAMB3;BRK1;FGFR1;Cel;CRTAP;RAN;ATM
protein homodimerization activityIKBKB;HMGCR;TRPM8;IRF3;HELT;UXS1;SLC14A2;ODC1;RNF17

TG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TG here. Most of them are supplied by our site. Hope this information will be useful for your research of TG.

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Toyota, H; Sudo, K; et al. Thy28 protects against anti-CD3-mediated thymic cell death in vivo. APOPTOSIS 20:444-454(2015).
Mukai, T; Gallant, R; et al. Loss of SH3 Domain-Binding Protein 2 Function Suppresses Bone Destruction in Tumor Necrosis Factor-Driven and Collagen-Induced Arthritis in Mice. ARTHRITIS & RHEUMATOLOGY 67:656-667(2015).
  • Q&As
  • Reviews

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Customer Reviews (3)

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Reviews
07/11/2021

    Enhancing efficiency, the biomolecular reagent yields fast experimental results.

    08/08/2019

      Suitable for long-term storage, the protein substance exhibits long-lasting stability.

      03/16/2017

        Emphasizing product innovation, the manufacturer regularly introduces new protein reagents.

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