tg
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  • Official Full Name
  • thyroglobulin
  • Background
  • Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis.
  • Synonyms
  • TG; thyroglobulin; TGN; AITD3; Thyroglobulin; Tg
Cat.#:TG-2112RTag:His-SUMO
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat TG Protein (21-300 aa), His-SUMO-tagged
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Cat.#:TG-708HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human TG Protein, MYC/DDK-tagged
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Cat.#:TG-3207HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TG, GST-tagged
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Cat.#:TG-4645HTag:N/A
Source (Host):NativeSpecies:Human
Product nameThyroglobulin(Human)
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Cat.#:TG-499HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TG Protein, His-tagged
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Cat.#:TG-8266HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human TG, GST-tagged
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Cat.#:TG-8267HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human TG, GST-tagged
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Cat.#:TG-16699MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TG Protein
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Cat.#:Tg-500MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Tg Protein, His-tagged
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Cat.#:TG-31519THTag:
Source (Host):Species:Human
Product nameNative Human TG
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Cat.#:TG-393HTag:N/A
Source (Host):Human thyroid glandsSpecies:Human
Product nameNative Human Thyroglobulin
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Cat.#:TG-8265HTag:N/A
Source (Host):Human thyroid glandsSpecies:Human
Product nameNative Human Thyroids Thyroglobulin
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Cat.#:TG-121BTag:N/A
Source (Host):Bovine thyroidSpecies:Bovine
Product nameNative Bovine TG
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Cat.#:TG-22PTag:
Source (Host):PorcineSpecies:Porcine
Product nameNative Porcine Thyroglobulin (TG) Protein
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Cat.#:TG-37PTag:
Source (Host):Porcine thyroid glandSpecies:Porcine
Product nameNative Porcine TG protein
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Cat.#:Kit-0814Tag:
Source (Host):Species:
Product nameTransglutaminase Activity Colorimetric Assay Kit
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Cat.#:Kit-2036Tag:
Source (Host):Species:
Product nameTriglyceride Colorimetric Assay Kit
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Cat.#:Kit-2277Tag:
Source (Host):Species:
Product nameTransglutaminase Inhibitor Screening Assay Kit
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Cat.#:Kit-0815Tag:
Source (Host):Species:
Product nameTriglyceride Quantification Kit
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Cat.#:TG-4HTag:
Source (Host):Species:Human
Product nameHuman Thyroglobulin (Tg) Reference Standard
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Cat.#:TG-337PITag:
Source (Host):PigSpecies:Pig
Product nameImmobilized Pig TG protein
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Involved Pathway

TG involved in several pathways and played different roles in them. We selected most pathways TG participated on our site, such as Thyroid hormone synthesis, Autoi, ne thyroid disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with TG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Thyroid hormone synthesis
HSP90B1; PLCB1; IYD; PRKCA; ATP1B2; ATP1A2; PRKACB; HSPA5; PRKCB; GPX7
Autoi
IL5; FAS; HLA-DOA; HLA-B; HLA-DOB; HLA-C; IFNA2; HLA-DRB5; HLA-A; IFNA4
ne thyroid disease
HLA-DQA1; HLA-DQB1; HLA-DMA; TSHB; TSHR; HLA-F; IFNA12; CD80; HLA-A; HLA-DPB1

Protein Function

TG has several biochemical functions, for example, anion binding, chaperone binding, hormone activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TG itself. We selected most functions TG had, and list some proteins which have the same functions with TG. You can find most of the proteins on our site.
Function
Related Protein
Function anion binding
Related Protein TG
Function chaperone binding
Related Protein DNAJA3B; BAG2; DNAJA4; SYVN1; BAG3; TSACC; BAG4; Alb; AHSA1L; PFDN6
Function hormone activity
Related Protein GUCA2A; NMB; SST6; INSL5B; PRL; PYYA; PRL2; CRHR2; IGF2A; CHGB
Function protein complex binding
Related Protein UGT1A6B; CAV3; STRN; MAPK8IP2; MLKL; NDUFA4; TMED10; CPS1; KAT6B; PTCH1
Function protein homodimerization activity
Related Protein ERBB3; G6PDX; NPM1; NKX2; KIT; IKBKB; ADD2; LGALS1; SYNE1; THRA

Interacting Protein

TG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TG here. Most of them are supplied by our site. Hope this information will be useful for your research of TG.
carB; q81xd7_bacan

TG Related Articles

Toyota, H; Sudo, K; et al. Thy28 protects against anti-CD3-mediated thymic cell death in vivo. APOPTOSIS 20:444-454(2015).
Mukai, T; Gallant, R; et al. Loss of SH3 Domain-Binding Protein 2 Function Suppresses Bone Destruction in Tumor Necrosis Factor-Driven and Collagen-Induced Arthritis in Mice. ARTHRITIS & RHEUMATOLOGY 67:656-667(2015).