TG

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TG

Official Full Name thyroglobulin
Background Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis.
Synonyms TG; thyroglobulin; TGN; AITD3; Thyroglobulin; Tg
    • Species :
    • Bovine
    • Human
    • Mouse
    • Pig
    • Porcine
    • Rat
    • Source :
    • Bovine Thyroid
    • E.coli
    • HEK293
    • Human
    • Human Thyroids
    • Mammalian Cell
    • Pig
    • Porcine
    • Porcine thyroid gland
    • Wheat Germ
    • Tag :
    • GST
    • His
    • SUMO
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Rat TG-2112R Recombinant Rat TG Protein (21-300 aa), His-SUMO-tagged E.coli His/SUMO
    Human TG-31519TH Native Human TG N/A
    Human TG-3207H Recombinant Human TG, GST-tagged E.coli GST
    Human TG-393H Native Human Thyroglobulin Human Thyroids N/A
    Human TG-4645H Thyroglobulin(Human) Human N/A
    Human TG-499H Recombinant Human TG Protein, His-tagged E.coli His
    Human TG-4H Human Thyroglobulin (Tg) Reference Standard N/A
    Human TG-708H Recombinant Human TG Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human TG-8265H Native Human Thyroids Thyroglobulin Human Thyroids N/A
    Human TG-8266H Recombinant Human TG, GST-tagged Wheat Germ GST
    Human TG-8267H Recombinant Human TG, GST-tagged Wheat Germ GST
    Mouse TG-16699M Recombinant Mouse TG Protein Mammalian Cell His
    Mouse Tg-500M Recombinant Mouse Tg Protein, His-tagged E.coli His
    Bovine TG-121B Native Bovine TG Bovine Thyroid N/A
    Porcine TG-22P Native Porcine Thyroglobulin (TG) Protein Porcine N/A
    Pig TG-337PI Immobilized Pig TG protein Pig N/A
    Porcine TG-37P Native Porcine TG protein Porcine thyroid gland N/A
    Kit-0814 Transglutaminase Activity Colorimetric Assay Kit N/A
    Kit-0815 Triglyceride Quantification Kit N/A
    Kit-2036 Triglyceride Colorimetric Assay Kit N/A
    Kit-2277 Transglutaminase Inhibitor Screening Assay Kit N/A

    TG involved in several pathways and played different roles in them. We selected most pathways TG participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with TG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Thyroid hormone synthesis TPO; IYD; PAX8; PRKCB; DUOXA2; ITPR3; SLC5A5; HSPA5; FXYD2; GPX5
    Autoi FAS; IFNA8; IFNA21; H2-AB1; HLA-DMB; HLA-DQB1; HLA-B; TPO; TSHB; HLA-DQA1
    ne thyroid disease IL4; TSHB; IFNA21; GZMB; IFNA5; Il2; HLA-DMA; H2-Q10; FAS; IL5

    TG has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by TG itself. We selected most functions TG had, and list some proteins which have the same functions with TG. You can find most of the proteins on our site.

    Function Related Protein
    anion binding TG
    chaperone binding CDC37L1; UBL4; UBL4A; HLA-B; CDKN1B; CALR; BAG3; PARK2; DNLZ; STIP1
    hormone activity PYY; SST1.1; PRL2C3; AVP; SMTLB; VIP; PTH1A; INS1; TSHB; MLN
    protein complex binding KLHL8; SH2B3; PPARA; CD2AP; VAMP2; NCK2; PFKP; CDH2; KAT2B; LZTFL1
    protein homodimerization activity MFF; ZBTB1; SETMAR; PGCP; NR6A1; HINT2; SUPV3L1; RPE; GNPTG; PRMT2

    TG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TG here. Most of them are supplied by our site. Hope this information will be useful for your research of TG.

    carB; q81xd7_bacan

    Toyota, H; Sudo, K; et al. Thy28 protects against anti-CD3-mediated thymic cell death in vivo. APOPTOSIS 20:444-454(2015).
    Mukai, T; Gallant, R; et al. Loss of SH3 Domain-Binding Protein 2 Function Suppresses Bone Destruction in Tumor Necrosis Factor-Driven and Collagen-Induced Arthritis in Mice. ARTHRITIS & RHEUMATOLOGY 67:656-667(2015).

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