| Description : |
Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
304.8 kDa |
| AA Sequence : |
MALVLEIFTLLASICWVSANIFEYQ VDAQPLRPCELQRETAFLKQADYVP QCAEDGSFQTVQCQNDGRSCWCVGA NGSEVLGSRQPGRPVACLSFCQLQK QQILLSGYINSTDTSYLPQCQDSGD YAPVQCDVQQVQCWCVDAEGMEVYG TRQLGRPKRCPRSCEIRNRRLLHGV GDKSPPQCSAEGEFMPVQCKFVNTT DMMIFDLVHSYNRFPDAFVTFSSFQ RRFPEVSGYCHCADSQGRELAETGL ELLLDEIYDTIFAGLDLPSTFTETT LYRILQRRFLAVQSVISGRFRCPTK CEVERFTATSFGHPYVPSCRRNGDY QAVQCQTEGPCWCVDAQGKEMHGTR QQGEPPSCAEGQSCASERQQALSRL YFGTSGYFSQHDLFSSPEKRWASPR VARFATSCPPTIKELFVDSGLLRPM VEGQSQQFSVSENLLKEAIRAIFPS RGLARLALQFTTNPKRLQQNLFGGK FLVNVGQFNLSGALGTRGTFNFSQF FQQLGLASFLNGGRQEDLAKPLSVG LDSNSSTGTPEAAKKDGTMNKPTVG SFGFEINLQENQNALKFLASLLELP EFLLFLQHAISVPEDVARDLGDVME TVLSSQTCEQTPERLFVPSCTTEGS YEDVQCFSGECWCVNSWGKELPGSR VRGGQPRCPTDCEKQRARMQSLMGS QPAGSTLFVPACTSEGHFLPVQCFN SECYCVDAEGQAIPGTRSAIGKPKK CPTPCQLQSEQAFLRTVQALLSNSS MLPTLSDTYIPQCSTDGQWRQVQCN GPPEQVFELYQRWEAQNKGQDLTPA KLLVKIMSYREAASGNFSLFIQSLY EAGQQDVFPVLSQYPSLQDVPLAAL EGKRPQPRENILLEPYLFWQILNGQ LSQYPGSYSDFSTPLAHFDLRNCWC VDEAGQELEGMRSEPSKLPTCPGSC EEAKLRVLQFIRETEEIVSASNSSR FPLGESFLVAKGIRLRNEDLGLPPL FPPREAFAEQFLRGSDYAIRLAAQS TLSFYQRRRFSPDDSAGASALLRSG PYMPQCDAFGSWEPVQCHAGTGHCW CVDEKGGFIPGSLTARSLQIPQCPT TCEKSRTSGLLSSWKQARSQENPSP KDLFVPACLETGEYARLQASGAGTW CVDPASGEELRPGSSSSAQCPSLCN VLKSGVLSRRVSPGYVPACRAEDGG FSPVQCDQAQGSCWCVMDSGEEVPG TRVTGGQPACESPRCPLPFNASEVV GGTILCETISGPTGSAMQQCQLLCR QGSWSVFPPGPLICSLESGRWESQL PQPRACQRPQLWQTIQTQGHFQLQL PPGKMCSADYADLLQTFQVFILDEL TARGFCQIQVKTFGTLVSIPVCNNS SVQVGCLTRERLGVNVTWKSRLEDI PVASLPDLHDIERALVGKDLLGRFT DLIQSGSFQLHLDSKTFPAETIRFL QGDHFGTSPRTWFGCSEGFYQVLTS EASQDGLGCVKCPEGSYSQDEECIP CPVGFYQEQAGSLACVPCPVGRTTI SAGAFSQTHCVTDCQRNEAGLQCDQ NGQYRASQKDRGSGKAFCVDGEGRR LPWWETEAPLEDSQCLMMQKFEKVP ESKVIFDANAPVAVRSKVPDSEFPV MQCLTDCTEDEACSFFTVSTTEPEI SCDFYAWTSDNVACMTSDQKRDALG NSKATSFGSLRCQVKVRSHGQDSPA VYLKKGQGSTTTLQKRFEPTGFQNM LSGLYNPIVFSASGANLTDAHLFCL LACDRDLCCDGFVLTQVQGGAIICG LLSSPSVLLCNVKDWMDPSEAWANA TCPGVTYDQESHQVILRLGDQEFIK SLTPLEGTQDTFTNFQQVYLWKDSD MGSRPESMGCRKDTVPRPASPTEAG LTTELFSPVDLNQVIVNGNQSLSSQ KHWLFKHLFSAQQANLWCLSRCVQE HSFCQLAEITESASLYFTCTLYPEA QVCDDIMESNAQGCRLILPQMPKAL FRKKVILEDKVKNFYTRLPFQKLMG ISIRNKVPMSEKSISNGFFECERRC DADPCCTGFGFLNVSQLKGGEVTCL TLNSLGIQMCSEENGGAWRILDCGS PDIEVHTYPFGWYQKPIAQNNAPSF CPLVVLPSLTEKVSLDSWQSLALSS VVVDPSIRHFDVAHVSTAATSNFSA VRDLCLSECSQHEACLITTLQTQPG AVRCMFYADTQSCTHSLQGQNCRLL LREEATHIYRKPGISLLSYEASVPS VPISTHGRLLGRSQAIQVGTSWKQV DQFLGVPYAAPPLAERRFQAPEPLN WTGSWDASKPRASCWQPGTRTSTSP GVSEDCLYLNVFIPQNVAPNASVLV FFHNTMDREESEGWPAIDGSFLAAV GNLIVVTASYRVGVFGFLSSGSGEV SGNWGLLDQVAALTWVQTHIRGFGG DPRRVSLAADRGGADVASIHLLTAR ATNSQLFRRAVLMGGSALSPAAVIS HERAQQQAIALAKEVSCPMSSSQEV VSCLRQKPANVLNDAQTKLLAVSGP FHYWGPVIDGHFLREPPARALKRSL WVEVDLLIGSSQDDGLINRAKAVKQ FEESRGRTSSKTAFYQALQNSLGGE DSDARVEAAATWYYSLEHSTDDYAS FSRALENATRDYFIICPIIDMASAW AKRARGNVFMYHAPENYGHGSLELL ADVQFALGLPFYPAYEGQFSLEEKS LSLKIMQYFSHFIRSGNPNYPYEFS RKVPTFATPWPDFVPRAGGENYKEF SELLPNRQGLKKADCSFWSKYISSL KTSADGAKGGQSAESEEEELTAGSG LREDLLSLQEPGSKTYSKSGPTRTR RLEQKLISEEDLAANDILDYKDDDD KV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
