timp2
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  • Official Full Name
  • TIMP metallopeptidase inhibitor 2
  • Background
  • This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008]
  • Synonyms
  • TIMP2; TIMP metallopeptidase inhibitor 2; DDC8; CSC-21K; metalloproteinase inhibitor 2; TIMP-2; tissue inhibitor of metalloproteinase 2; tissue inhibitor of metalloproteinases 2;
Cat.#:TIMP2-1027HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human TIMP2 Protein, MYC/DDK-tagged
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Cat.#:TIMP2-001HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human TIMP2, MIgG2a Fc-tagged
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Cat.#:TIMP2-002HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human TIMP2, HIgG1 Fc-tagged
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Cat.#:TIMP2-152HTag:T7|His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TIMP2 protein, T7/His-tagged
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Cat.#:TIMP2-15HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TIMP2, His-tagged
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Cat.#:TIMP2-2529HTag:N/A
Source (Host):CHOSpecies:Human
Product nameRecombinant Human TIMP Metallopeptidase Inhibitor 2
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Cat.#:TIMP2-2887HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human TIMP Metallopeptidase Inhibitor 2
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Cat.#:TIMP2-29289THTag:N/A
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human TIMP2 protein
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Cat.#:TIMP2-37HTag:His
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human TIMP2 Protein, His-tagged
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Cat.#:TIMP2-3835HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human TIMP2, None tagged
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Cat.#:TIMP2-448HTag:His
Source (Host):HEK293FSpecies:Human
Product nameRecombinant Human TIMP2 protein, His-tagged
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Cat.#:TIMP2-603HTag:His
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human TIMP2 Protein, His-tagged
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Cat.#:TIMP2-604HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TIMP2 Protein, His-tagged
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Cat.#:TIMP2-880HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human TIMP2, Fc tagged
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Cat.#:Timp2-542MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Timp2 protein, His-tagged
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Cat.#:Timp2-660MTag:N/A
Source (Host):NSO CellsSpecies:Mouse
Product nameRecombinant Mouse Timp2
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Cat.#:Timp2-543RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Timp2 protein, His-tagged
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Cat.#:TIMP2-6077RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TIMP2 Protein
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Cat.#:TIMP2-540DTag:His
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog TIMP2 protein, His-tagged
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Cat.#:TIMP2-5871CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TIMP2
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Cat.#:TIMP2-539CTag:His|T7
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle TIMP2 protein, His & T7-tagged
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Cat.#:TIMP2-541HTag:His
Source (Host):E. coliSpecies:Horse
Product nameRecombinant Horse TIMP2 protein, His-tagged
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Cat.#:TIMP2-5141HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TIMP Metallopeptidase Inhibitor 2
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Cat.#:TIMP2-881HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TIMP2, His-tagged
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Cat.#:TIMP2-8460HTag:N/A
Source (Host):Human fibroblastsSpecies:Human
Product nameNative Human TIMP2
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Cat.#:TIMP2-2061HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human TIMP2 cell lysate
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Involved Pathway

TIMP2 involved in several pathways and played different roles in them. We selected most pathways TIMP2 participated on our site, such as Activation of Matrix Metalloproteinases, Angiogenesis, Degradation of the extracellular matrix, which may be useful for your reference. Also, other proteins which involved in the same pathway with TIMP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Activation of Matrix Metalloproteinases
CTSLL; CTSK; TIMP2; CTSL2; CTRB1; CTSG; MGC174857; LOC100686744; FURINA; MMP8
Angiogenesis
CREBBP; TIMP2
Degradation of the extracellular matrix
COL19A1; COL9A1; COL9A3; CTSL1; BMP1B; MMP12; TIMP2; COL17A1; TLL1; ADAM8A
Extracellular matrix organization
PRP; LOXL3; COL25A1; CD151; KLK7; LOXL4; TPSAB1; ABHD1; MMP17; FAM49BA
Matrix Metalloproteinases
MMP17; MMP12; TIMP4; MMP27; MMP8; MMP19; MMP20; TIMP2; BSG; MMP23B

Protein Function

TIMP2 has several biochemical functions, for example, enzyme activator activity, integrin binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TIMP2 itself. We selected most functions TIMP2 had, and list some proteins which have the same functions with TIMP2. You can find most of the proteins on our site.
Function
Related Protein
Function enzyme activator activity
Related Protein GTF3C4; PRKCD; GM1679; MMP24; SEC14L2; OGT; ALOX5AP; CFLAR; PRKCE; CTAGE5
Function integrin binding
Related Protein AMICA1; NISCH; ICAM1; CXADR; COL5A1; FCER2; WISP1A; KDR; FBN1; FERMT3
Function metal ion binding
Related Protein ZGPAT; ZNF488; ZSCAN4D; RNASEL; COL1A1; GTF2H3; ZSCAN16; RXRBB; EIF2S2; FOXP2
Function metalloendopeptidase inhibitor activity
Related Protein RECK; SPOCK1; TIMP1; TIMP3; COL4A3; SPOCK3; NGF; TIMP4; BST2; FETUB
Function protease binding
Related Protein TIMP2A; Cstb; CD28; MALT1; IL1R1; PYCARD; SERPINF2; POLG; ITGA3; SERPINA1
Function protein binding
Related Protein SLC30A8; CCNT1; IRAK4; POLR2J; C8orf4; TLE1; KLF10; TMX3; AOC3; CAML

Interacting Protein

TIMP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TIMP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TIMP2.
MMP2; 51464480; PGRMC1; PSMA7; SNCG; HSPA4L; APC2; RAB3A; PCMT1; PAICS; ECHS1; RANBP1; RPL29; MMP14; NPEPPS; PSMA6; PSME3; GANAB; NUDC

TIMP2 Related Articles

Bennett, RG; Heimann, DG; et al. Relaxin decreases the severity of established hepatic fibrosis in mice. LIVER INTERNATIONAL 34:416-426(2014).
Albert, CR; Schlesinger, WJ; et al. Effect of Hydroxychloroquine on Antiphospholipid Antibody-Induced Changes in First Trimester Trophoblast Function. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY 71:154-164(2014).