TJP1
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Official Full Name
tight junction protein 1 (zona occludens 1)
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Overview
Tight junctions, or zona occludens, form a continuous barrier to fluids across the epithelium and endothelium. They function in regulation of paracellular permeability and in the maintenance of cell polarity, blocking the movement of transmembrane protein -
Synonyms
TJP1; tight junction protein 1 (zona occludens 1); tight junction protein ZO-1; DKFZp686M05161; MGC133289; tight junction protein ZO 1; ZO 1; zona occludens 1; zona occludens protein 1; zonula occludens 1 protein; zonula occludens protein 1; ZO-1;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Dog
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
TJP1 involved in several pathways and played different roles in them. We selected most pathways TJP1 participated on our site, such as Adherens junction, Tight junction, Gap junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with TJP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adherens junction | ACTN2B;MET;ACTG1;ACTN3A;FYNA;ACTB;EGFRA;WASF2;PTPRJA |
| Tight junction | GNAI2;MYH15;MYH13;RHOA;YES1;MLLT4;PRKCZ;MYH9;PRKCB |
| Gap junction | PDGFRB;GNAS;Pdgfa&Pdgfb;TUBA3C;HRASA;PRKG1A;Adcy4;MAP3K2;TUBB1 |
| Vibrio cholerae infection | ATP6AP1;ATP6V0D1;PRKCA;PRKACB;SEC61G;ATP6V1E2;MUC2;ATP6V1H;ATP6V1G1 |
| Epithelial cell signaling in Helicobacter pylori infection | ATP6V1H;F11R;ATP6V1G3;MET;MAPK10;ATP6V1B1;IKBKG;NOD1;SRC |
| Salmonella infection | RAC1A;CCL3;PKN3;IFNGR2;TJP1;RILP;MYH9;RHOGB;DYNC1I1 |
TJP1 has several biochemical functions, for example, calmodulin binding, protein binding, protein domain specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TJP1 itself. We selected most functions TJP1 had, and list some proteins which have the same functions with TJP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calmodulin binding | EPB41;SLC9A1;MAPKAPK2B;RIT1;SPATA17;CAMKV;NOS3;PHKG2;TRPV5 |
| protein binding | E4F1;JMY;APEH;TBX15;PRKRIR;TSC22D3;TSR2;KIF14;SIM1 |
| protein domain specific binding | PHRF1;ARFIP2A;PLG;MYO1D;HIST1H4N;ARR3;PLAUR;NFASC;STXBP1 |
TJP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TJP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TJP1.
GJA1; ACTN4; Gjc1; Wwtr1; GJD3; VMP1; Gja1
- Q&As
- Reviews
Q&As (5)
Ask a questionTJP1 is being investigated as a potential target in cancer therapy due to its role in regulating cell adhesion and migration.
Researchers are exploring ways to modulate TJP1 expression and function to develop treatments for diseases involving tight junction dysfunction.
Yes, TJP1 dysfunction is also associated with conditions like celiac disease and certain types of cancer.
Therapies may include drugs aimed at restoring TJP1 function or regulating its expression to reduce inflammation in IBD.
TJP1 is studied through techniques like immunohistochemistry, genetic sequencing, and functional assays to understand its role in specific diseases.
Customer Reviews (3)
Write a reviewThey ensure the purity, integrity, and functionality of ARHGEF10L protein through rigorous quality control measures.
This guidance allows me to design and implement experiments effectively while adhering to best practices, enhancing the reliability and reproducibility of my results.
the manufacturer's commitment to quality control is essential in achieving reliable and consistent outcomes
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