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Recombinant Dog TJP1 Protein (1633-1769 aa), His-tagged

Cat.No. : TJP1-833D
Product Overview : Recombinant Dog TJP1 Protein (1633-1769 aa) is produced by E. coli expression system. This protein is fused with a 6xHis tag at the N-terminal. Protein Description: Partial.
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Description : The N-terminal may be involved in transducing a signal required for tight junction assbly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.
Source : E. coli
Species : Dog
Tag : His
Form : Tris-based buffer, 50% glycerol
Molecular Mass : 18.7 kDa
Protein length : 1633-1769 aa
AA Sequence : VVATARGVFNNNGGVLSSIETGVSI IIPQGAIPEGVEQEIYFKVCRDNSI LPPLDKEKGETLLSPLVMCGPHGLK FLKPVELRLPHCASMTPDGWSFALK SSDSSSGDPKTWQNKCLPGDPNYLV GANCVSVLIDHF
Purity : > 90% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA with concentration instruction is sent along with the products.
Gene Name : TJP1 tight junction protein 1 (zona occludens 1) [ Canis lupus familiaris ]
Official Symbol : TJP1
Synonyms : TJP1; zonula occludens 1; ZO1; ZO-1;
Gene ID : 403752
mRNA Refseq : NM_001003140
Protein Refseq : NP_001003140
UniProt ID : O97758

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can TJP1 be a target for drug development in cancer? 01/19/2018

TJP1 is being investigated as a potential target in cancer therapy due to its role in regulating cell adhesion and migration.

How can TJP1 be targeted for therapeutic interventions? 08/19/2017

Researchers are exploring ways to modulate TJP1 expression and function to develop treatments for diseases involving tight junction dysfunction.

Are there any other diseases where TJP1 is implicated? 10/11/2016

Yes, TJP1 dysfunction is also associated with conditions like celiac disease and certain types of cancer.

What are potential therapeutic approaches to target TJP1 in IBD? 02/24/2016

Therapies may include drugs aimed at restoring TJP1 function or regulating its expression to reduce inflammation in IBD.

How is TJP1 studied in a clinical context? 02/22/2016

TJP1 is studied through techniques like immunohistochemistry, genetic sequencing, and functional assays to understand its role in specific diseases.

Customer Reviews (3)

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Reviews
03/05/2017

    They ensure the purity, integrity, and functionality of ARHGEF10L protein through rigorous quality control measures.

    11/20/2016

      This guidance allows me to design and implement experiments effectively while adhering to best practices, enhancing the reliability and reproducibility of my results.

      09/13/2016

        the manufacturer's commitment to quality control is essential in achieving reliable and consistent outcomes

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