tlr10
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  • Official Full Name
  • toll-like receptor 10
  • Background
  • The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene.
  • Synonyms
  • TLR10; toll-like receptor 10; CD290; MGC104967; MGC126398; MGC126399; OTTHUMP00000158729; CD290 antigen; TLR10_HUMAN; Toll like receptor 10; OTTHUMP00000218160; OTTHUMP00000218161; OTTHUMP00000218162
Cat.#:TLR10-2080HTag:His|GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TLR10 protein, His & GST-tagged
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Cat.#:Tlr10-2081RTag:His|T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Tlr10 protein, His & T7-tagged
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Cat.#:TLR10-4730RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey TLR10 Protein, His-tagged
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Cat.#:TLR10-1046HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human TLR10 293 Cell Lysate
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Involved Pathway

TLR10 involved in several pathways and played different roles in them. We selected most pathways TLR10 participated on our site, such as Disease, Diseases associated with the TLR signaling cascade, Diseases of Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with TLR10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Disease
KPNA4; EPM2A; TNKS2; BANF1; WHSC2; SYT2; PSIP1; STRA6; HDAC6; TNKS
Diseases associated with the TLR signaling cascade
TIRAP; TLR10; TICAM1; TLR6
Diseases of Immune System
TIRAP; TLR6; TLR10
IRAK4 deficiency (TLR5)
TLR10
Immune System
HCST; ASB9; LILRB1; AGER; KIR3DS1; IFIT3; TXN; CTS7; IFIT8; GHRB
Innate Immune System
BTR18; SIRPB1; LGALS3; TLR6; DEFB125; WASF3; ABI1A; PPAPDC1B; FCN2; CYLD
MyD88 cascade initiated on plasma membrane
S100B; DUSP3B; TLR10; PELI2; ALCAMB; CHST13; S100A12; TNIP2; DHX9; AGER
Toll Like Receptor 10 (TLR10) Cascade
TLR10

Protein Function

TLR10 has several biochemical functions, for example, transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TLR10 itself. We selected most functions TLR10 had, and list some proteins which have the same functions with TLR10. You can find most of the proteins on our site.
Function
Related Protein
Function transmembrane signaling receptor activity
Related Protein CLEC1B; LYVE1; LILRA1; NPC1; ANTXR1; GHRHR2; SPN; GP6; BCAM; GIPR

TLR10 Related Articles

Matas-Cobos, AM; Redondo-Cerezo, E; et al. The Role of Toll-Like Receptor Polymorphisms in Acute Pancreatitis Occurrence and Severity. PANCREAS 44:429-433(2015).
Skipor, J; Szczepkowska, A; et al. PROFILE OF TOLL-LIKE RECEPTOR mRNA EXPRESSION IN THE CHOROID PLEXUS IN ADULT EWES. ACTA VETERINARIA HUNGARICA 63:69-78(2015).