tnfrsf10a
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  • Official Full Name
  • tumor necrosis factor receptor superfamily, member 10a
  • Background
  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008]
  • Synonyms
  • TNFRSF10A; tumor necrosis factor receptor superfamily, member 10a; DR4; APO2; CD261; TRAILR1; TRAILR-1; tumor necrosis factor receptor superfamily member 10A; TRAIL-R1; TRAIL receptor 1; death receptor 4; cytotoxic TRAIL receptor; TNF-related apoptosis-inducing ligand receptor 1; tumor necrosis factor receptor superfamily member 10a variant 2;
Cat.#:TNFRSF10A-248HTag:Fc Chimera
Source (Host):Baculovirus Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human TNFRSF10A, Fc Chimera
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Cat.#:TNFRSF10A-249HTag:Fc Chimera
Source (Host):CHO cellsSpecies:Human
Product nameRecombinant Human TNFRSF10A, Fc Chimera
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Cat.#:TNFRSF10A-27024THTag:Fc
Source (Host):Species:Human
Product nameRecombinant Human TNFRSF10A, Fc-tagged
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Cat.#:TNFRSF10A-312HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNFRSF10A Protein
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Cat.#:TNFRSF10A-3131HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF10A, Fc tagged
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Cat.#:TNFRSF10A-3168HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF10A, His tagged
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Cat.#:TNFRSF10A-49HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human TRAIL-R1, Fc Chimera
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Cat.#:TNFRSF10A-524HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF10A, Fc-tagged
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Cat.#:TNFRSF10A-597HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human TNFRSF10A, Fc-tagged, Biotinylated
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Cat.#:TNFRSF10A-883HTag:FC/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF10A, Fc-His tagged
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Cat.#:TNFRSF10A-112HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNFRSF10A
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Cat.#:TNFRSF10A-2180HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF10A cell lysate
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Involved Pathway

TNFRSF10A involved in several pathways and played different roles in them. We selected most pathways TNFRSF10A participated on our site, such as Cytokine-cytokine receptor interaction, Apoptosis, Natural killer cell mediated cytotoxicity, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFRSF10A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
MET; IL2RG; IL6R; ACVR2AA; BMPR1AB; KITB; MPL; Il23a; TNFRSF10A; TSLP
Apoptosis
TRP53; IRF4; DIABLO; BID; JUN; HIST1H1C; CASP4; RIPK1L; BCL2A; TNF
Natural killer cell mediated cytotoxicity
Ifna15; MAP2K2; FAS; PRKCG; PLCG1; IFNA5; RAF1; RAC2; TNFRSF10D; MICA
Measles
GSK3B; CCND1; TNFRSF10C; IL1B; TNFRSF10A; OAS1B; IRF7; IKBKE; PIK3R1; IFNA5
Influenza A
PRSS2; TLR4; IFNA14; MYD88; MAPK10; PRSS1; PIK3CB; NFKBIA; TNF; PABPN1L

Protein Function

TNFRSF10A has several biochemical functions, for example, TRAIL binding, death receptor activity, protease binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFRSF10A itself. We selected most functions TNFRSF10A had, and list some proteins which have the same functions with TNFRSF10A. You can find most of the proteins on our site.
Function
Related Protein
Function TRAIL binding
Related Protein TNFRSF10B; Tnfrsf22; TNFRSF10A; TNFRSF10C; TNFRSF10D
Function death receptor activity
Related Protein TNFRSF10A; NGFR
Function protease binding
Related Protein Casp3; TYSND1; DVL3; CCDC71L; SERPINB9; ITGB1; Serpina1b; Serpina1c; DPP4; KIT
Function protein binding
Related Protein CLDN7; IST1; LBP; SHANK3; IL15RA; CASKIN1; CALD1; UBL5; AVPR1A; DACT1
Function receptor activity
Related Protein ANTXR2; CD33; MED24; STRA6; TMEM123; P2RY1; ITGAX; ADIPOR2; GRIK3; CD93
Function transcription factor binding
Related Protein BRD7; PIK3R1; TRIB1; HMGB2; BCL2; FOXO1; SOX8; HMGA2; FOXA3; CSNK2B
Function tumor necrosis factor-activated receptor activity
Related Protein NRADD; TNFRSF6B; TNFRSF11B; TNFRSF8; HDR; TNFRSFA; Tnfrsf26; LTBR; TNFRSF9; TNFRSF11A

Interacting Protein

TNFRSF10A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFRSF10A here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFRSF10A.
CASP8; TNFSF10; ARAP1

TNFRSF10A Related Gene Family

TNF