tnfrsf10c
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  • Official Full Name
  • tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
  • Background
  • Tumor necrosis factor receptor superfamily member 10C is a protein that in humans is encoded by the TNFRSF10C gene. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL.
  • Synonyms
  • TNFRSF10C; CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3; TRAILR3; TRID; tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
Cat.#:TNFRSF10C-546HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF10C Protein, His-tagged
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Cat.#:TNFRSF10C-307HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF10C Protein
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Cat.#:TNFRSF10C-308HTag:Fc/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF10C Protein, Fc/His-tagged
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Cat.#:TNFRSF10C-576HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNFRSF10C protein, His & GST-tagged
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Cat.#:TNFRSF10C-594HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human TNFRSF10C, Fc-tagged, Biotinylated
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Cat.#:TNFRSF10C-68HTag:Fc
Source (Host):Species:Human
Product nameRecombinant Human TRAIL-R3, Fc-tagged
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Cat.#:TNFRSF10C-1640RTag:
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey TNFRSF10C Protein
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Cat.#:TNFRSF10C-1692HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human TNFRSF10C
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Cat.#:TNFRSF10C-2096HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF10C, Fc-tagged
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Cat.#:TNFRSF10C-893HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TNFRSF10C 293 Cell Lysate
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Involved Pathway

TNFRSF10C involved in several pathways and played different roles in them. We selected most pathways TNFRSF10C participated on our site, such as Cytokine-cytokine receptor interaction, Apoptosis, Natural killer cell mediated cytotoxicity, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFRSF10C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
PDGFC; IFNPHI1; CD40LG; IFNL3; KDR; EDAR; Il4ra; Cxcl15; PRLRA; FLT4
Apoptosis
BOK; FADD; IL3; VIML; PRKACG; CASP6; BNIP3L; PRKAR2B; NFKBIAB; HDR
Natural killer cell mediated cytotoxicity
PPP3R1; ULBP1; VAV1; IFNAR1; SHC2; KLRD1; MAPK3; ARAF; IFNA16; NFATC1
Measles
FASLG; IL1A; IFNA21; NFKBIA; OAS2; NFKB1; BBC3; IFNG; TRP53; IFNA10
Influenza A
IFNA7; ADAR; GSK3B; BMA2; HLA-DMB; FASLG; XPO1; TLR4; TNFRSF10A; AKT1

Protein Function

TNFRSF10C has several biochemical functions, for example, TRAIL binding, transmembrane signaling receptor activity, tumor necrosis factor-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFRSF10C itself. We selected most functions TNFRSF10C had, and list some proteins which have the same functions with TNFRSF10C. You can find most of the proteins on our site.
Function
Related Protein
Function TRAIL binding
Related Protein TNFRSF10A; TNFRSF10B; TNFRSF10D; Tnfrsf22; TNFRSF10C
Function transmembrane signaling receptor activity
Related Protein FZD8B; KLRD1; SELE; CD300C; TLR9; FCGR2C; OR4D6; FZD7B; TLR2-2; GP1BB
Function tumor necrosis factor-activated receptor activity
Related Protein TNFRSF11B; TNFRSF14; TNFRSF8; TNFRSF21; TNFRSF18; TNFRSF6B; TNFRSF19; TNFRSF25; NGFR; TNFRSF9A

Interacting Protein

TNFRSF10C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFRSF10C here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFRSF10C.
TNFSF10; SRPK2; SRPK1; APOA1; SLC25A6; LRSAM1; FAM101B; ZHX1

TNFRSF10C Related Articles

Li, ZB; Guo, XW; et al. Methylation profiling of 48 candidate genes in tumor and matched normal tissues from breast cancer patients. BREAST CANCER RESEARCH AND TREATMENT 149:767-779(2015).
Ratzinger, G; Mitteregger, S; et al. Association of TNFRSF10D DNA-Methylation with the Survival of Melanoma Patients. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 15:11984-11995(2014).