Recombinant Human TNFRSF10C protein, His & GST-tagged

• Cat.No.: TNFRSF10C-576H
• Product Overview: Recombinant Human TNFRSF10C aa. (Glu32~Thr244 (Accession # O14798)) fused with N-terminal His & GST tag was produced in E. coli cells.

Specification

• Description: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL.
• Source: E. coli
• Species: Human
• Tag: His & GST
• Form: Freeze-dried powder
• Molecular Mass: 66kDa as determined by SDS-PAGE reducing conditions.
• Protein length: Glu32~Thr244 (Accession # O14798)
• Endotoxin: <1.0EU per 1µg (determined by the LAL method)
• Purity: >90%
• Characteristic: The isoelectric point is 4.5.
• Applications: SDS-PAGE; WB; ELISA; IP
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Storage buffer: Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.

Gene Information

• Gene Name: TNFRSF10C TNF receptor superfamily member 10c [ Homo sapiens (human) ]
• Official Symbol: TNFRSF10C
• Synonyms: TNFRSF10C; TNF receptor superfamily member 10c; LIT; DCR1; TRID; CD263; TRAILR3; TRAIL-R3; DCR1-TNFR; tumor necrosis factor receptor superfamily member 10C; TNF-related apoptosis-inducing ligand receptor 3; antagonist decoy receptor for TRAIL/Apo-2L; cytotoxic TRAIL receptor-3; decoy TRAIL receptor without death domain; decoy receptor 1; lymphocyte inhibitor of TRAIL; tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
• Gene ID: 8794
• mRNA Refseq: NM_003841.4
• Protein Refseq: NP_003832.2
• UniProt ID: O14798