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TNNT1

  • Official Full Name

    troponin T type 1 (skeletal, slow)

  • Overview

    This gene encodes a protein that is a subunit of troponin, which is a regulatory complex located on the thin filament of the sarcomere. This complex regulates striated muscle contraction in response to fluctuations in intracellular calcium concentration. This complex is composed of three subunits: troponin C, which binds calcium, troponin T, which binds tropomyosin, and troponin I, which is an inhibitory subunit. This protein is the slow skeletal troponin T subunit. Mutations in this gene cause nemaline myopathy type 5, also known as Amish nemaline myopathy, a neuromuscular disorder characterized by muscle weakness and rod-shaped, or nemaline, inclusions in skeletal muscle fibers which affects infants, resulting in death due to respiratory insufficiency, usually in the second year. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    troponin T, slow skeletal muscle; sTnT; tnTs; troponin T1, skeletal, slow; slow skeletal muscle troponin T;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TNNT1-606H Recombinant Human TNNT1 Protein, DDK-tagged Sf9 Insect Cell DDK
Human TNNT1-3334H Recombinant Human TNNT1, GST-tagged E.coli GST C-term--252aa
Human TNNT1-7947H Recombinant Human TNNT1 protein, His-tagged E.coli His Met1~Gly259
Human TNNT1-881HCL Recombinant Human TNNT1 293 Cell Lysate HEK293 N/A
Human TNNT1-1915HFL Recombinant Full Length Human TNNT1 Protein, C-Flag-tagged Mammalian cells Flag
Human TNNT1-2228H-B Recombinant Human TNNT1 Protein Pre-coupled Magnetic Beads HEK293
Human TNNT1-2228H Recombinant Human TNNT1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human TNNT1-13H Recombinant Human TNNT1 Protein E. coli 278 aa
Mouse Tnnt1-7948M Recombinant Mouse Tnnt1 protein, His-tagged E.coli His Met1~Lys261 (Accession # O88346)
Mouse TNNT1-17198M Recombinant Mouse TNNT1 Protein Mammalian Cell His
Mouse TNNT1-9499M-B Recombinant Mouse TNNT1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Tnnt1-6570M Recombinant Mouse Tnnt1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse TNNT1-9499M Recombinant Mouse TNNT1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Tnnt1-7949R Recombinant Rat Tnnt1 protein, His-tagged E.coli His Met1~Lys228 (Accession # Q7TNB2)
Rat TNNT1-6210R Recombinant Rat TNNT1 Protein Mammalian Cell His
Rat TNNT1-5867R-B Recombinant Rat TNNT1 Protein Pre-coupled Magnetic Beads HEK293
Rat TNNT1-5867R Recombinant Rat TNNT1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish TNNT1-9626Z Recombinant Zebrafish TNNT1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

TNNT1 involved in several pathways and played different roles in them. We selected most pathways TNNT1 participated on our site, such as Muscle contraction, Striated Muscle Contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNNT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Muscle contractionTNNT1;TMOD4;TNNI2;TNNT3B;MYL6B;TNNI2B.1;ANXA2;TCAP;MYL1
Striated Muscle ContractionTNNT1;MYBPC2B;TNNI2B.2;TMOD4;DESMA;TNNI1B;TNNI1;ACTA1B;MYBPC3

TNNT1 has several biochemical functions, for example, protein binding, tropomyosin binding, troponin T binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNNT1 itself. We selected most functions TNNT1 had, and list some proteins which have the same functions with TNNT1. You can find most of the proteins on our site.

Function Related Protein
protein bindingBAG5;PGK1;ALDOA;SH3BP2;SIP1;ARHGEF10;RAB5C;MRPL4;TTC12
tropomyosin bindingTMOD3;TNNT1;NEBL;LMOD1;LMOD2A;TMOD4;PYCARD;TMOD1;S100A6
troponin T bindingTNNT1;TNNI2;TNNI3;TNNC1

TNNT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNNT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNNT1.

TPM1; LDOC1; TBPL1; NFE2L2; TPM3; KRT40; CCDC136

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