TNNT1 Protein, troponin T type 1 (skeletal, slow)

TNNT1

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TNNT1

Official Full Name troponin T type 1 (skeletal, slow)
Background This gene encodes a protein that is a subunit of troponin, which is a regulatory complex located on the thin filament of the sarcomere. This complex regulates striated muscle contraction in response to fluctuations in intracellular calcium concentration. This complex is composed of three subunits: troponin C, which binds calcium, troponin T, which binds tropomyosin, and troponin I, which is an inhibitory subunit. This protein is the slow skeletal troponin T subunit. Mutations in this gene cause nemaline myopathy type 5, also known as Amish nemaline myopathy, a neuromuscular disorder characterized by muscle weakness and rod-shaped, or nemaline, inclusions in skeletal muscle fibers which affects infants, resulting in death due to respiratory insufficiency, usually in the second year. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms troponin T, slow skeletal muscle; sTnT; tnTs; troponin T1, skeletal, slow; slow skeletal muscle troponin T
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • DDK
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TNNT1-3334H Recombinant Human TNNT1, GST-tagged E.coli GST
    Human TNNT1-606H Recombinant Human TNNT1 Protein, DDK-tagged Sf9 Insect Cell DDK
    Human TNNT1-7947H Recombinant Human TNNT1 protein, His-tagged E.coli His
    Human TNNT1-881HCL Recombinant Human TNNT1 293 Cell Lysate HEK293 N/A
    Mouse TNNT1-17198M Recombinant Mouse TNNT1 Protein Mammalian Cell His
    Mouse Tnnt1-7948M Recombinant Mouse Tnnt1 protein, His-tagged E.coli His
    Rat TNNT1-6210R Recombinant Rat TNNT1 Protein Mammalian Cell His
    Rat Tnnt1-7949R Recombinant Rat Tnnt1 protein, His-tagged E.coli His
    Zebrafish TNNT1-9626Z Recombinant Zebrafish TNNT1 Mammalian Cell His

    TNNT1 involved in several pathways and played different roles in them. We selected most pathways TNNT1 participated on our site, such as Muscle contraction, Striated Muscle Contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNNT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Muscle contraction DMD; MYBPC2; MYL12A; MYL9; TMOD4; TNNI1; ANXA6; TNNT1; TNNI2B.2; MYBPC3
    Striated Muscle Contraction TMOD3; MYLZ3; TNNT3; TNNI1B; TMOD2; TNNI2A.1; TNNI1; SMYHC3; DMD; MYBPC2A

    TNNT1 has several biochemical functions, for example, protein binding, tropomyosin binding, troponin T binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNNT1 itself. We selected most functions TNNT1 had, and list some proteins which have the same functions with TNNT1. You can find most of the proteins on our site.

    Function Related Protein
    protein binding VAMP3; C15orf57; ELMO3; ABTB1; OXR1; POLR2L; ANKMY2; SMARCC1; MET; HER11
    tropomyosin binding TNNT1; TMOD3; TMOD4; TNNT2A; TMOD1; TMOD2; PYCARD; S100A6; LMOD3; CALD1
    troponin T binding TNNT1; TNNC1; TNNI2; TNNI3

    TNNT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNNT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNNT1.

    TPM1; LDOC1; TBPL1; NFE2L2; TPM3; KRT40; CCDC136

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