Tph2
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Official Full Name
tryptophan hydroxylase 2
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Overview
Tryptophan Hydroxylase (TPH) belongs to the biopterin-dependent aromatic amino acid hydroxylase family. This enzyme catalyzes the first and rate limiting step in the biosynthesis of serotonin. Mutations in this gene have been implicated in a variety of di -
Synonyms
TPH2; tryptophan hydroxylase 2; tryptophan 5-hydroxylase 2; FLJ37295; NTPH; tryptophan 5-monooxygenase 2; neuronal tryptophan hydroxylase; ADHD7; MGC138871; MGC138872;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Homo sapiens (Human)
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Flag
- GST
- His
- His (Fc)
- Avi
- His|GST
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- Tph2 Related Articles
- Tph2 Related Research Area
Tph2 involved in several pathways and played different roles in them. We selected most pathways Tph2 participated on our site, such as Amine-derived hormones, Metabolic pathways, Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with Tph2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Amine-derived hormones | TPH2;DDC;CGA;DIO2;DBH |
| Metabolic pathways | PCYT2;SAT1A.1;SAT1;OTC;CES1D;NDUFA1;INPP1;GCNT4;CES1 |
| Metabolism | LBR;CYGB;BSG;ACOT11A;ACSF2;APOBB.1;ABHD3;UGT1B3;DBH |
| Metabolism of amino acids and derivatives | IVD;SLC6A7;LSM1;GLS2B;PAOX;AZIN1A;OAZ1;AZIN2;IDO2 |
| Monoamine Transport | TPH2;HRH3;SCAMP2;TGFB1I1;SYN1;UNC13B;DBH;FBXO32 |
| SIDS Susceptibility Pathways | CDCA7L;SST;LMX1B;MAZ;CREM;KCNH2;CHRFAM7A;POU3F2;PKNOX1 |
| Serotonergic synapse | MAOA;CYP2C39;Casp3;MAPK1;HTR7;CYP2C37;GNAS;ALOX15;TRPC1 |
| Serotonin Transporter Activity | SCAMP2;TPH2;TGFB1I1 |
Tph2 has several biochemical functions, for example, amino acid binding, iron ion binding, tryptophan 5-monooxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Tph2 itself. We selected most functions Tph2 had, and list some proteins which have the same functions with Tph2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| amino acid binding | OTC;SHMT2;DPYS;TPH1A;TPH2;AARS;DDAH2;AGXT;KARS |
| iron ion binding | JMJD6;CYP4B1;CYP27B1;HBB-B2;AOX1;POR;TPH1B;CYP24A1;ALOX5A |
| tryptophan 5-monooxygenase activity | TPH1A;TH2;TPH2;TPH1;TPH1B |
Tph2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Tph2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Tph2.
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- Q&As
- Reviews
Q&As (5)
Ask a questionTargeting TPH2 through pharmacological agents or gene therapies may be explored to modulate serotonin levels and alleviate mood disorders.
TPH2 dysregulation may lead to imbalances in serotonin, contributing to the pathogenesis of anxiety disorders.
TPH2 has been studied in the context of neurodegenerative disorders due to its influence on serotonin, which has neuroprotective properties.
Yes, drugs targeting TPH2 or the serotonin pathway are being investigated for their potential in developing novel psychiatric medications.
Yes, genetic variations can affect TPH2 expression, contributing to individual differences in serotonin levels and susceptibility to mood disorders.
Customer Reviews (3)
Write a reviewIts consistent and accurate results, combined with its compatibility with various cutting-edge techniques, ensure that data collection and analysis are both reliable and meaningful.
The TPH2 protein's exceptional performance in ELISA and its successful application in protein electron microscopy structure analysis make it a highly reliable and recommended choice for researchers.
The manufacturer's commitment to delivering a high-quality product further enhances its reputation and guarantees its suitability for a wide range of research applications.
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