Recombinant Full Length Human TPH2 Protein, C-Flag-tagged

• Cat.No.: TPH2-1148HFL
• Product Overview: Recombinant Full Length Human TPH2 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 55.9 kDa
• AA Sequence: MQPAMMMFSSKYWARRGFSLDSAVP EEHQLLGSSTLNKPNSGKNDDKGNK GSSKREAATESGKTAVVFSL KNEVGGLVKALRLFQEKRVNMVHIE SRKSRRRSSEVEIFVDCECGKTEFN ELIQLLKFQTTIVTLNPPEN IWTEEEELEDVPWFPRKISELDKCS HRVLMYGSELDADHPGFKDNVYRQR RKYFVDVAMGYKYGQPIPRV EYTEEETKTWGVVFRELSKLYPTHA CREYLKNFPLLTKYCGYREDNVPQL EDVSMFLKERSGFTVRPVAG YLSPRDFLAGLAYRVFHCTQYIRHG SDPLYTPEPDTCHELLGHVPLLADP KFAQFSQEIGLASLGASDED VQKLATCYFFTIEFGLCKQEGQLRA YGAGLLSSIGELKHALSDKACVKAF DPKTTCLQECLITTFQEAYF VSESFEEAKEKMRDFAKSITRPFSV YFNPYTQSIEILKDTRSIENVVQDL RSDLNTVCDALNKMNQYLGITRTRP LEQKLISEEDLAANDILDYKDDDDK V
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome
• Protein Pathways: Metabolic pathways, Tryptophan metabolism

Gene Information

• Gene Name: TPH2 tryptophan hydroxylase 2 [ Homo sapiens (human) ]
• Official Symbol: TPH2
• Synonyms: NTPH; ADHD7
• Gene ID: 121278
• mRNA Refseq: NM_173353.4
• Protein Refseq: NP_775489.2
• MIM: 607478
• UniProt ID: Q8IWU9