trem1
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  • Official Full Name
  • Triggering receptor expressed on myeloid cells 1
  • Background
  • TREM-1 stimulates neutrophil and monocyte-mediated inflammatory responses. It triggers release of pro- inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. TREM-1 is an amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock. It interacts with TYROBP/DAP12. TREM-1 is highly expressed in adult liver, lung and spleen than in corresponding fetal tissue. It is also expressed in the lymph node, placenta, spinal cord and heart tissues. Expression is more elevated in peripheral blood leukocytes than in the bone marrow and in normal cells than malignant cells. TREM-1 is expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. It is strongly expressed in acute inflammatory lesions caused by bacteria and fungi. Isoform 2 was detected in the lung, liver and mature monocytes. TREM-1 is up-regulated by bacteria, fungi and bacterial lipopolysaccharides (LPS).
  • Synonyms
  • CD354; TREM-1; triggering receptor expressed on monocytes 1; triggering-receptor TREM1
Cat.#:TREM1-167HTag:T7/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TREM1 protein, T7/His-tagged
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Cat.#:TREM1-212HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TREM1 Protein, His-tagged
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Cat.#:TREM1-285HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Soluble triggering receptor expressed on myeloid cells 1, His-tagged
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Cat.#:TREM1-30119THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TREM1, His-tagged
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Cat.#:TREM1-3842HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TREM1, His tagged
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Cat.#:TREM1-7203HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Triggering Receptor Expressed On Myeloid Cells 1, His-tagged
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Cat.#:TREM1-886HTag:FC/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TREM1, Fc-His tagged
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Cat.#:Trem1-17319MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Trem1 protein, His-tagged
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Cat.#:Trem1-213MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Trem1 Protein, His-tagged
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Cat.#:TREM1-1779RTag:
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey TREM1 Protein
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Cat.#:TREM1-1780RTag:hIgG1
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey TREM1 Protein, hIgG1-tagged
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Cat.#:TREM1-1781RTag:hIgG4
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey TREM1 Protein, hIgG4-tagged
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Cat.#:TREM1-211CTag:His
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle TREM1 Protein, His-tagged
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Cat.#:TREM1-214PTag:His
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig TREM1 Protein, His-tagged
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Cat.#:TREM1-2140HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human TREM1 cell lysate
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Involved Pathway

TREM1 involved in several pathways and played different roles in them. We selected most pathways TREM1 participated on our site, such as Adaptive Immune System, Cell surface interactions at the vascular wall, DAP12 interactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with TREM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
AMICA1; AP2A1; ASB7; DYNC1I2; CLTA; CD200R2; FRS2B; RNF220; AP1G1; ASB14
Cell surface interactions at the vascular wall
GAS6; GRB7; GRB14; SLC3A2B; CEACAM1; CD177; BSG; CD84; ANGPT2A; NADL1.1
DAP12 interactions
KLB; PEA15A; NRG3; GRAP2B; SPNA2; PEA15; HBEGF; FGF18B; SPRED1; NRG4
Hemostasis
KIF26A; KIF20A; GRB14; KIF5B; BA2; KIF15; PRKCHB; CD9B; SLC7A6; KIF9
Immune System
FBXO44; ASB17; FCN1; FBXO3; EIF4G2; DEFB116; TCIRG1; OSBPL1A; BFB; KLHL21
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
OSCAR; CD300LF; MICA; CLEC2B; Siglece; CD300LD; KLRF1; CD96; PVRL2L; CLEC2G
Innate Immune System
ABI1B; RNF216; LGALS3; DEFA5; SIGIRR; DUSP3; TLR10; SUGT1; ABI1A; KIR2DS2

Protein Function

TREM1 has several biochemical functions, for example, receptor activity, scaffold protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TREM1 itself. We selected most functions TREM1 had, and list some proteins which have the same functions with TREM1. You can find most of the proteins on our site.
Function
Related Protein
Function receptor activity
Related Protein LYVE1; LILRA2; CD200R4; TNFRSF6B; GFRA1A; NOTCH2; NLGN2B; PVRL1B; VPREB1; NLGN2
Function scaffold protein binding
Related Protein KCNH2; NOS1; KRT8; ADCY6; CHUK; P2RY1; HOMER1; CRIPT; MAP2K2; NLRP1