TREM1

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TREM1

Official Full Name Triggering receptor expressed on myeloid cells 1
Background TREM-1 stimulates neutrophil and monocyte-mediated inflammatory responses. It triggers release of pro- inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. TREM-1 is an amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock. It interacts with TYROBP/DAP12. TREM-1 is highly expressed in adult liver, lung and spleen than in corresponding fetal tissue. It is also expressed in the lymph node, placenta, spinal cord and heart tissues. Expression is more elevated in peripheral blood leukocytes than in the bone marrow and in normal cells than malignant cells. TREM-1 is expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. It is strongly expressed in acute inflammatory lesions caused by bacteria and fungi. Isoform 2 was detected in the lung, liver and mature monocytes. TREM-1 is up-regulated by bacteria, fungi and bacterial lipopolysaccharides (LPS).
Synonyms CD354; TREM-1; triggering receptor expressed on monocytes 1; triggering-receptor TREM1
    • Species :
    • Cattle
    • Human
    • Mouse
    • Pig
    • Rhesus monkey
    • Source :
    • E.coli
    • HEK293
    • Human Cell
    • Mouse
    • Tag :
    • APC
    • Fc
    • His
    • hIgG1
    • hIgG4
    • N/A
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human DMABT-H18610 Mouse Anti-TREM1 Monoclonal Antibody Mouse APC
    Human DMABT-H18611 Mouse Anti-TREM1 Monoclonal Antibody Mouse N/A
    Human TREM1-167H Recombinant Human TREM1 protein, T7/His-tagged E.coli T7/His
    Human TREM1-212H Recombinant Human TREM1 Protein, His-tagged E.coli His
    Human TREM1-2140HCL Recombinant Human TREM1 cell lysate Human Cell N/A
    Human TREM1-285H Recombinant Human Soluble triggering receptor expressed on myeloid cells 1, His-tagged E.coli His
    Human TREM1-30119TH Recombinant Human TREM1, His-tagged E.coli His
    Human TREM1-3842H Recombinant Human TREM1, His tagged Human Cell His
    Human TREM1-7203H Recombinant Human Triggering Receptor Expressed On Myeloid Cells 1, His-tagged E.coli His
    Human TREM1-886H Recombinant Human TREM1, Fc-His tagged Human Cell Fc/His
    Mouse Trem1-17319M Recombinant Mouse Trem1 protein, His-tagged HEK293 His
    Mouse Trem1-213M Recombinant Mouse Trem1 Protein, His-tagged E.coli His
    Rhesus monkey TREM1-1779R Recombinant Rhesus Monkey TREM1 Protein HEK293 N/A
    Rhesus monkey TREM1-1780R Recombinant Rhesus Monkey TREM1 Protein, hIgG1-tagged HEK293 hIgG1
    Rhesus monkey TREM1-1781R Recombinant Rhesus Monkey TREM1 Protein, hIgG4-tagged HEK293 hIgG4
    Cattle TREM1-211C Recombinant Cattle TREM1 Protein, His-tagged E.coli His
    Pig TREM1-214P Recombinant Pig TREM1 Protein, His-tagged E.coli His

    TREM1 involved in several pathways and played different roles in them. We selected most pathways TREM1 participated on our site, such as Adaptive Immune System, Cell surface interactions at the vascular wall, DAP12 interactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with TREM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adaptive Immune System CD300A; FGF18B; RAPGEF4; ASB8; AGO1; AP2S1; FCGR1B; ASB14; GAN; MAPKAP1
    Cell surface interactions at the vascular wall SLC3A2A; FCER1GL; DOK2; F11R.2; SLC16A1; SLC3A2B; GRB14; ANGPT2A; ITGB1B.1; GRB7
    DAP12 interactions WDR83; GRAP2A; FGF18B; CNKSR1; THEM4; KIR3DS1; PEA15A; SPNA1; KIR2DS2; FRS3
    Hemostasis HBG1; SLC3A2A; IRF1B; DOCK8; CD177; F9B; MAFGB; TRPC7; ATP2B1B; HBBE2
    Immune System DUSP3; IFI30; TRIM5; TRIM69; MAP3K8; DEFA3; UFL1; LILRA1; CR1; CLEC2D
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell CLEC2B; KLRB1F; CD300LH; CD96; SIGLEC7; Siglece; PVRL2L; SIGLEC5; CD200R3; TREML4
    Innate Immune System PPAPDC1A; DEFA6; ALCAMB; CYLD; SIRPB1; LGALS3; CASP4; POLR3C; CD300LB; DUSP3

    TREM1 has several biochemical functions, for example, receptor activity, scaffold protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TREM1 itself. We selected most functions TREM1 had, and list some proteins which have the same functions with TREM1. You can find most of the proteins on our site.

    Function Related Protein
    receptor activity EPHB6; VMN1R50; CLEC4E; ABP1; TNFRSF13B; NLGN2; NOTCH1; IGSF1; NEO1; TNFRSF11B
    scaffold protein binding CHUK; KCNA5; KCNQ1; DLG4; KRT15; MAP2K2; SRC; GRID2; ATP2B4; PANX1

    TREM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TREM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TREM1.

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