|Product Overview:||Recombinant Mouse Trem1(Ala21-Ser202) fused with 10-his tag at C-terminal was expressed in HEK293.|
|Description:||Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) is a transmembrane protein with a single Ig-like domain. TREM-1 associates with the adapter protein, DAP12, to deliver an activating signal. TREM-1 is expressed on blood neutrophils and monocytes, and the expression is up-regulated by bacterial LPS. TREM-1 is expressed at high levels on neutrophils of patients with microbial sepsis and in mice with a TREM-1/Fc fusion protein protected mice against LPS-induced shock. It stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. TREM-1 is amplifier of inflammatory responses that are triggered by bacterial and fungal infections and are a crucial mediator of septic shock.|
|Form:||Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.|
|AA Sequence:||AIVLEEERYDLVEGQTLTVKCPFNIMKYANSQKAWQRLPDGKEPLTLVVTQRPFTRPSEVHMGKF TLKHDPSEAMLQVQMTDLQVTDSGLYRCVIYHPPNDPVVLFHPVRLVVTKGSSDVFTPVIIPITR LTERPILITTKYSPSDTTTTRSLPKPTAVVSSPGLGVTIINGTDADSVSTSSHHHHHH|
|Endotoxin:||Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.|
|Purity:||Greater than 95% as determined by reducing SDS-PAGE.|
|Storage:||Lyophilized protein should be stored at < -20 centigrade, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7 centigrade for 2-7 days.
Aliquots of reconstituted samples are stable at < -20 centigrade for 3 months.
|Reconstitution:||Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
|Shipping:||The product is shipped at ambient temperature.|
|Gene Name:||Trem1 triggering receptor expressed on myeloid cells 1 [ Mus musculus ]|
|Synonyms:||TREM1; triggering receptor expressed on myeloid cells 1; triggering receptor expressed in monocytes 1;|
|Chromosome Location:||17; 17 C|
|Pathway:||Cell surface interactions at the vascular wall, organism-specific biosystem; Hemostasis, organism-specific biosystem;|