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Recombinant Mouse Trem1 protein, His-tagged

Cat.No. : Trem1-17319M
Product Overview : Recombinant Mouse Trem1(Ala21-Ser202) fused with 10-his tag at C-terminal was expressed in HEK293.
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  • Gene Information
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Description : Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) is a transmembrane protein with a single Ig-like domain. TREM-1 associates with the adapter protein, DAP12, to deliver an activating signal. TREM-1 is expressed on blood neutrophils and monocytes, and the expression is up-regulated by bacterial LPS. TREM-1 is expressed at high levels on neutrophils of patients with microbial sepsis and in mice with a TREM-1/Fc fusion protein protected mice against LPS-induced shock. It stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. TREM-1 is amplifier of inflammatory responses that are triggered by bacterial and fungal infections and are a crucial mediator of septic shock.
Source : HEK293
Species : Mouse
Tag : His
Form : Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
Protein length : Ala21-Ser202
AA Sequence : AIVLEEERYDLVEGQTLTVKCPFNI MKYANSQKAWQRLPDGKEPLTLVVT QRPFTRPSEVHMGKF TLKHDPSEAMLQVQMTDLQVTDSGL YRCVIYHPPNDPVVLFHPVRLVVTK GSSDVFTPVIIPITR LTERPILITTKYSPSDTTTTRSLPK PTAVVSSPGLGVTIINGTDADSVST SSHHHHHH
Endotoxin : Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
Purity : Greater than 95% as determined by reducing SDS-PAGE.
Storage : Lyophilized protein should be stored at < -20 centigrade, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7 centigrade for 2-7 days.
Aliquots of reconstituted samples are stable at < -20 centigrade for 3 months.
Reconstitution : Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Shipping : The product is shipped at ambient temperature.
Gene Name : Trem1 triggering receptor expressed on myeloid cells 1 [ Mus musculus ]
Official Symbol : Trem1
Synonyms : TREM1; triggering receptor expressed on myeloid cells 1; triggering receptor expressed in monocytes 1;
Gene ID : 58217
mRNA Refseq : NM_021406
Protein Refseq : NP_067381
UniProt ID : Q9JKE2
Chromosome Location : 17; 17 C
Pathway : Cell surface interactions at the vascular wall, organism-specific biosystem; Hemostasis, organism-specific biosystem;
Function : receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Does TREM1 protein have antimicrobial effects? 11/03/2019

TREM1 protein can enhance inflammatory response during infection, but its specific relationship with antibacterial effect still needs further study.

What is the role of TREM1 protein in the treatment of lung diseases? 08/25/2019

High expression of the TREM1 protein in lung disease can trigger an excessive inflammatory response, and controlling its activity may help reduce the symptoms and inflammatory damage of lung disease.

How is the TREM1 protein related to bacterial infections? 04/22/2019

When bacterial infection occurs, the expression of the TREM1 protein increases, which enhances the inflammatory response, which helps clear the infection and regulate the inflammatory process.

What immune response is the TREM1 protein involved in? 03/20/2019

TREM1 protein is involved in immune response processes such as macrophage activation, release of inflammatory mediators, and recruitment and regulation of immune cells.

What are the implications of the study of TREM1 protein for the treatment of inflammatory diseases? 02/04/2019

The study of TREM1 protein helps to understand the regulatory mechanism of inflammatory response and provide new targets and strategies for the treatment of inflammatory diseases.

Does the TREM1 protein have the potential to predict and monitor disease progression? 01/12/2019

High expression of the TREM1 protein is associated with the development and prognosis of certain diseases and can therefore serve as a biomarker for predicting and monitoring disease progression.

Customer Reviews (3)

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Reviews
05/19/2022

    The exceptional stability of TREM1 makes it an invaluable tool for a wide range of applications.

    01/18/2020

      Manufacturer's commitment to environmental sustainability is evident in its production processes, using green and renewable resources.

      10/06/2019

        TREM1 has a short half-life, making it more effective and less likely to cause side effects compared to other similar proteins.

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