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TULP3

  • Official Full Name

    tub

  • Overview

    This gene encodes a member of the tubby gene family of bipartite transcription factors. Members of this family have been identified in plants, vertebrates, and invertebrates, and they share a conserved N-terminal transcription activation region and a conserved C-terminal DNA and phosphatidylinositol-phosphate binding region. The encoded protein binds to phosphoinositides in the plasma membrane via its C-terminal region and probably functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis, for instance, induced by G-protein-coupled-receptor signaling. It plays an important role in neuronal development and function. Two transcript variants encoding distinct isoforms have been identified for this gene.
  • Synonyms

    TULP3; tub; tubby-related protein 3; TUBL3; MGC45295; Tubby like protein 3; Tubby related protein 3; Tubby-like protein 3; TUBL 3; TULP 3; TULP3_HUMAN;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Mamanlian cells
  • Mammalian Cell
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TULP3-213H Recombinant Human TULP3 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human TULP3-638HCL Recombinant Human TULP3 293 Cell Lysate HEK293 N/A
Human TULP3-1998H Recombinant Human TULP3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human TULP3-301433H Recombinant Human TULP3 protein, GST-tagged E.coli GST Asp96-Glu442
Human TULP3-5759HFL Recombinant Full Length Human TULP3 protein, Flag-tagged Mamanlian cells Flag
Mouse TULP3-17635M Recombinant Mouse TULP3 Protein Mammalian Cell His
Mouse TULP3-9772M-B Recombinant Mouse TULP3 Protein Pre-coupled Magnetic Beads HEK293
Mouse Tulp3-6737M Recombinant Mouse Tulp3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse TULP3-9772M Recombinant Mouse TULP3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque TULP3-5029R Recombinant Rhesus monkey TULP3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque TULP3-4842R-B Recombinant Rhesus Macaque TULP3 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque TULP3-4842R Recombinant Rhesus Macaque TULP3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein

TULP3 involved in several pathways and played different roles in them. We selected most pathways TULP3 participated on our site, such as Hedgehog off state, Signal Transduction, Signaling by Hedgehog, which may be useful for your reference. Also, other proteins which involved in the same pathway with TULP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Hedgehog off stateIFT122;GPR161;TULP3;WDR35;OFD1;INTU;RPGRIP1L;IFT172;BBS13
Signal TransductionPTGDR2;HECW1;HCAR1-2;AKAP13;ARHGAP18;TNKS;HECW1B;CCL19A.2;USP34
Signaling by HedgehogIFT122;CDON;EVC;WDR19;IFT52;BBS13;WDR35;TTC21B;MKS1

TULP3 has several biochemical functions, for example, enzyme binding, phosphatidylinositol binding, phosphatidylinositol-4,5-bisphosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TULP3 itself. We selected most functions TULP3 had, and list some proteins which have the same functions with TULP3. You can find most of the proteins on our site.

Function Related Protein
enzyme bindingCBS;KAT8;UGT1A6A;PARP1;CYP2A6;TGFB1;N4BP2L2;NPM2;LAMP2
phosphatidylinositol bindingAKR1C1;SNX2;SNX9A;TNFAIP8L3;ARHGAP32;CCDC88A;MYO1E;SNX32;SGK3
phosphatidylinositol-4,5-bisphosphate bindingPFN2;COMMD1;PFN1;KCNJ2;CCDC167;CHMP3;FRMPD4;KCNQ1;SESTD1
protein bindingALG13;CADM1;LDHD;NKX2-1;PCMT1;KATNBL1;FER;PSMB4;MPLKIP
protein complex bindingCCND1;ATF1;STRN4;CFLAR;HSPD1;VHLL;NDUFA8;PPP2R2A;MLC1

TULP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TULP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TULP3.

PSTPIP1; MAGEA6; KRTAP10-5; KRTAP10-7; ANKRD54; ROPN1

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