TXNDC12
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Official Full Name
thioredoxin domain containing 12 (endoplasmic reticulum)
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Overview
This gene encodes a member of the thioredoxin superfamily. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. This protein localizes to the endoplasmic reticulum and has a single atypical active motif. The encoded protein is mainly involved in catalyzing native disulfide bond formation and displays activity similar to protein-disulfide isomerases. This protein may play a role in defense against endoplasmic reticulum stress. Alternate splicing results in both coding and non-coding variants. -
Synonyms
TXNDC12; thioredoxin domain containing 12 (endoplasmic reticulum); thioredoxin domain-containing protein 12; AGR1; anterior gradient homolog 1 (Xenopus laevis); endoplasmic reticulum thioredoxin superfamily member; 18 kDa; ERP18; ERP19; hAG 1; PDIA16; pro;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Yeast
- His
- His (Fc)
- Avi
- SUMO
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
TXNDC12 involved in several pathways and played different roles in them. We selected most pathways TXNDC12 participated on our site, such as Glutathione metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with TXNDC12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glutathione metabolism | GGT5;GSTP2;OPLAH;ANPEPB;GSTM2;GPX3;RRM2;LAP3;GGT5A |
TXNDC12 has several biochemical functions, for example, peptide disulfide oxidoreductase activity, protein binding, protein-disulfide reductase (glutathione) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TXNDC12 itself. We selected most functions TXNDC12 had, and list some proteins which have the same functions with TXNDC12. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| peptide disulfide oxidoreductase activity | Txn1;TXNDC12;TXN |
| protein binding | CCDC116;SERPINA1A;TK1;CARD8;HSPB8;YOD1;HSPA13;FAM200A;RPIA |
| protein-disulfide reductase (glutathione) activity |
TXNDC12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TXNDC12 here. Most of them are supplied by our site. Hope this information will be useful for your research of TXNDC12.
SGTA; KLHL2; SGTB; UBQLN1; UBQLN1; ZDHHC17; H2AFX
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