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Tert

  • Official Full Name

    Telomerase reverse transcriptase

  • Overview

    Telomerase is a ribonucleoprotein complex that replicates telomere ends by the addition of the Telomere repeat TTAGGG. Human Telomerase Reverse Transcriptase (hTERT) is one of the three core components of the enzyme-the catalytic subunit. Since male germ cells and the majority of human cancers have unlimited replicative capacity, they observe high levels of telomerase activity. hTERT is repressed in most somatic cells expect in proliferating progenitor cells and activated lymphocytes. In contrast, hTERT is activated in approximately 85% of human cancer tissues. Due to the biological function of hTERT, it has been seen as the most general of tumor markers known and has significant potential for diagnostics, prognostics, and therapeutics.
  • Synonyms

    DKCA2; DKCB4; EST2; PFBMFT1; TCS1; TP2; TRT; hEST2; hTRT; telomerase catalytic subunit; telomerase-associated protein 2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • Mammalian Cell
  • C
  • His
  • His (Fc)
  • Avi
  • His|GST
  • His|SUMO
  • N/A
  • N
  • GST
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TERT-560H Human Telomerase reverse transcriptase peptide N/A 550-600
Human TERT-374H Recombinant Human TERT Mammalian Cell His
Human Tert-550H Recombinant Human Tert E.coli N/A
Human TERT-1144HCL Recombinant Human TERT 293 Cell Lysate HEK293 N/A
Human TERT-4175H Recombinant Human TERT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human TERT-438H Recombinant Human TERT Protein, His/GST-tagged E.coli His/GST Arg787~Arg1084
Human TERT-056H Recombinant Human TERT protein, His-tagged E.coli His 409aa
Human TERT-32H Recombinant Human TERT Protein, His-tagged E.coli His
Human TERT-6411H Recombinant Human TERT Protein (Lys902-Asp1069), N-His tagged E.coli N-His Lys902-Asp1069
Human TERT-2459H Recombinant Human TERT protein(241-310 aa), C-His-tagged E. coli C-His 241-310 aa
Human TERT-4175H-B Recombinant Human TERT Protein Pre-coupled Magnetic Beads HEK293
Human TERT-6412H Recombinant Human TERT Protein (Arg787-Arg1084), N-GST tagged E.coli N-GST Arg787-Arg1084
Mouse TERT-16646M Recombinant Mouse TERT Protein Mammalian Cell His
Mouse Tert-1383M Recombinant Mouse Tert Protein, His-SUMO-tagged E.coli His/SUMO
Mouse Tert-574M Recombinant Mouse Telomerase Reverse Transcriptase E.coli N/A
Mouse TERT-9132M Recombinant Mouse TERT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Tert-439M Recombinant Mouse Tert Protein, His/GST-tagged E.coli His/GST Gln642~Lys974
Mouse TERT-9132M-B Recombinant Mouse TERT Protein Pre-coupled Magnetic Beads HEK293
Rat TERT-6014R Recombinant Rat TERT Protein Mammalian Cell His
Rat TERT-5673R Recombinant Rat TERT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Tert-440R Recombinant Rat Tert Protein, His-tagged E.coli His Thr673~His976
Rat TERT-5673R-B Recombinant Rat TERT Protein Pre-coupled Magnetic Beads HEK293
Zebrafish TERT-5473Z Recombinant Zebrafish TERT Mammalian Cell His
Chicken TERT-2688C Recombinant Chicken TERT Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Tert Related Research Area

Tert involved in several pathways and played different roles in them. We selected most pathways Tert participated on our site, such as HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with Tert were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
HTLV-I infectionNFATC4;ANAPC11;TNFRSF1A;HRAS;TP53;NFKB1;PRKACB;CDC16;TGFBR1

Tert has several biochemical functions, for example, DNA binding, RNA binding, RNA-directed DNA polymerase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Tert itself. We selected most functions Tert had, and list some proteins which have the same functions with Tert. You can find most of the proteins on our site.

Function Related Protein
DNA bindingMAFGB;HMX1;RARGA;CDC5L;ZNF221;TRNP1;TOPORS;ZFP354A;JUNBB
RNA bindingOAS1B;DNMT1;NHP2L1A;AKAP1B;RBFOX2;IMPDH2;IFIT12;SRSF9;CNBPA
RNA-directed DNA polymerase activity
contributes_to RNA-directed RNA polymerase activity
metal ion bindingGALNTL4;CALUA;ITGB2;ZNF669;GALNT13;PHF23B;CYP2K19;ZYMND12;DNAJA4
nucleotidyltransferase activityPOLR3B;CMASA;MOCS3;POLE2;OASL2;PAPSS2;PRIM2;POLN;TERT
protein bindingPAK4;USP54;UPRT;ENTPD5;VPS11;NUDT4;SPARC;ENTPD3;TACR1
protein homodimerization activityHMGCL;PLEK;NKX2;S100A16;FOXP3;GYS2;AP1S2;C16orf89;NFS1
tRNA bindingCARS;FARS2;FDXACB1;CTU1;ALKBH8;TERT;PSTK;TRMT1L;FARSA
telomerase RNA bindingWRAP53;PINX1;NOP10;HNRNPU;TERT;GAR1;DKC1;HNRNPC;NHP2
telomerase RNA reverse transcriptase activity
contributes_to telomerase RNA reverse transcriptase activity
telomerase activityPRIM2;CCDC111;PTGES3;DKC1;TERT;UAP1L1;CTU1
telomeric DNA bindingNCL;TERFA;SMG6;TERF2;TERF1;HNRNPD;TEN1;XRCC5;PIF1
transcription coactivator bindingTERT;RORA;PASD1;ZBTB49;NR4A3

Tert has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Tert here. Most of them are supplied by our site. Hope this information will be useful for your research of Tert.

terc_human_rna; RUVBL1

  • Q&As
  • Reviews

Q&As (5)

Ask a question
Are there genetic mutations associated with TERT that have clinical relevance? 09/03/2021

Yes, mutations in the TERT gene have been identified in certain genetic disorders. Understanding these mutations can be crucial for diagnosing and managing related conditions.

What are the challenges associated with targeting TERT for therapeutic purposes? 04/11/2021

One challenge is the potential impact on normal, healthy cells, as they also rely on TERT for telomere maintenance. Specific targeting of cancer cells without affecting normal cells is a significant hurdle.

What are the ethical considerations surrounding the manipulation of TERT for medical purposes? 01/27/2018

The ethical implications include concerns about unintended consequences, potential misuse, and ensuring equitable access to TERT-based therapies.

Can TERT expression be used as a predictive marker for treatment response in cancer patients? 03/27/2016

Research suggests that TERT expression levels may be indicative of treatment response. Patients with higher TERT expression might respond differently to certain therapies.

How does TERT contribute to aging, and are there potential anti-aging applications? 03/18/2016

TERT's role in maintaining telomeres is linked to cellular aging. Exploring ways to modulate TERT expression could have implications for anti-aging interventions.

Customer Reviews (3)

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Reviews
07/24/2021

    This existing knowledge base provides a solid foundation for designing experiments and interpreting results, ultimately enhancing the efficiency and reliability of trials involving TERT protein.

    02/02/2018

      With their support, I can confidently explore the intricacies of TERT and make significant contributions to the understanding of its functions in various biological processes.

      08/15/2017

        Extensive research has been conducted on TERT, making it relatively accessible and well-understood in terms of its structure and functions.

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