UBA7

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UBA7

Official Full Name ubiquitin-like modifier activating enzyme 7
Background The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein.
Synonyms UBA7; ubiquitin-like modifier activating enzyme 7; UBE1L, ubiquitin activating enzyme E1 like; ubiquitin-like modifier-activating enzyme 7; D8; UBA1; ubiquitin activating enzyme E1 homolog B (yeast); UBA1B; ubiquitin activating enzyme E1; UBE2; MGC12713; UBA7_HUMAN; Ube 1L; UBE 2; Ubiquitin activating enzyme 2; Ubiquitin activating enzyme E1 homolog; Ubiquitin Activating Enzyme E1 Like; Ubiquitin activating enzyme E1 related protein; Ubiquitin-activating enzyme 7; Ubiquitin-activating enzyme E1 homolog; OTTHUMP00000212701; ubiquitin-activating enzyme-2; UBA7, ubiquitin-activating enzyme E1; UBA1, ubiquitin-activating enzyme E1 homolog B; ubiquitin; UBE1L
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • T7
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human UBA7-6310H Recombinant Human UBA7 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Uba7-6770M Recombinant Mouse Uba7 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human UBA7-171H Recombinant Human UBA7, His-tagged Insect Cell His
    Human UBA7-5755H Recombinant Human UBA7 protein, His & T7-tagged E.coli His/T7
    Human UBA7-601HCL Recombinant Human UBA7 293 Cell Lysate HEK293 N/A
    Human UBA7-629H Recombinant Human UBA7, His-tagged E.coli His
    Human UBA7-833H Recombinant Human UBA7, GST-tagged Sf9 Insect Cell GST
    Mouse Uba7-5756M Recombinant Mouse Uba7 protein, His & T7-tagged E.coli His/T7
    Rat Uba7-5757R Recombinant Rat Uba7 protein, His & T7-tagged E.coli His/T7

    UBA7 involved in several pathways and played different roles in them. We selected most pathways UBA7 participated on our site, such as Ubiquitin mediated proteolysis, Parkinsons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBA7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ubiquitin mediated proteolysis TRAF6; UBE2IA; SOCS3; MDM2; MGRN1; FBXW11A; BIRC7; MID1; PIAS4A; RNF7
    Parkinsons disease COX5A; COX7A2L; NDUFB11; CASP9; TH; SLC25A4; NDUFA1; ATP5F1; COX8C; UBE2G2

    UBA7 has several biochemical functions, for example, ATP binding, ISG15 activating enzyme activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBA7 itself. We selected most functions UBA7 had, and list some proteins which have the same functions with UBA7. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding MYO1D; C10orf2; GATB; MKNK2A; RIPK1; KIF18A; MAP3K14; RBKS; MAPK10; MYLK3
    ISG15 activating enzyme activity UBA7
    protein binding CBFA2T2; CEP120; NCOA2; JAM2; MYOZ2; SERPINB3C; ZNF397; GK; HIST1H2AI; PDCD4
    ubiquitin activating enzyme activity UBA7; ATG7; UBA1; UBA6; SAE1; UBE1Y1
    ubiquitin-protein transferase activity LRSAM1; RNF115; MIB2; FBXO25; TRIM56; RNF11; UBE2R2; SIAH2L; XIAP; PEX12

    UBA7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBA7 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBA7.

    ISG15; 15-deoxy-delta(12,14; SHFM1

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