uba7
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  • Official Full Name
  • ubiquitin-like modifier activating enzyme 7
  • Background
  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein.
  • Synonyms
  • UBA7; ubiquitin-like modifier activating enzyme 7; UBE1L, ubiquitin activating enzyme E1 like; ubiquitin-like modifier-activating enzyme 7; D8; UBA1; ubiquitin activating enzyme E1 homolog B (yeast); UBA1B; ubiquitin activating enzyme E1; UBE2; MGC12713; UBA7_HUMAN; Ube 1L; UBE 2; Ubiquitin activating enzyme 2; Ubiquitin activating enzyme E1 homolog; Ubiquitin Activating Enzyme E1 Like; Ubiquitin activating enzyme E1 related protein; Ubiquitin-activating enzyme 7; Ubiquitin-activating enzyme E1 homolog; OTTHUMP00000212701; ubiquitin-activating enzyme-2; UBA7, ubiquitin-activating enzyme E1; UBA1, ubiquitin-activating enzyme E1 homolog B; ubiquitin; UBE1L
Cat.#:UBA7-171HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human UBA7, His-tagged
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Cat.#:UBA7-5755HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UBA7 protein, His & T7-tagged
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Cat.#:UBA7-629HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UBA7, His-tagged
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Cat.#:UBA7-833HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human UBA7, GST-tagged
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Cat.#:Uba7-5756MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Uba7 protein, His & T7-tagged
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Cat.#:Uba7-5757RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Uba7 protein, His & T7-tagged
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Cat.#:UBA7-601HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human UBA7 293 Cell Lysate
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Involved Pathway

UBA7 involved in several pathways and played different roles in them. We selected most pathways UBA7 participated on our site, such as Ubiquitin mediated proteolysis, Parkinsons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBA7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ubiquitin mediated proteolysis
KEAP1; PIAS4A; UBE2L3A; RHOBTB1; CUL3A; UBA6; TCEB1; UBE2N; UBE2I; CDC20
Parkinsons disease
UBE2G1; UBB; NDUFB5; NDUFS5; Atp5g2; ATP5A1; NDUFS1; NDUFB7; MT-ND1; ATP5H

Protein Function

UBA7 has several biochemical functions, for example, ATP binding, ISG15 activating enzyme activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBA7 itself. We selected most functions UBA7 had, and list some proteins which have the same functions with UBA7. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein SPG7; SMC5; KSR1; UBE2Q1; BRIP1; PRKCE; TRPM6; MYLK2; NLRP4C; GUK1
Function ISG15 activating enzyme activity
Related Protein UBA7
Function protein binding
Related Protein IQSEC3; TLR4; BUC; RPS10; PLIN1; KCNA5; MDFI; RSPH1; ODAM; GSTM5
Function ubiquitin activating enzyme activity
Related Protein UBA6; UBE1Y1; UBA1; SAE1; ATG7; UBA7
Function ubiquitin-protein transferase activity
Related Protein IRAK1; RNF213; ARIH1; FBXL21; FBXL14A; WWP1; RCHY1; UBE2D2; RNF182; RBBP6

Interacting Protein

UBA7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBA7 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBA7.
ISG15; 15-deoxy-delta(12,14; SHFM1