UNC5B Protein, unc-5 homolog B (C. elegans)


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Official Full Name unc-5 homolog B (C. elegans)
Background This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene.
Synonyms UNC5B; unc-5 homolog B (C. elegans); unc5 (C.elegans homolog) b; netrin receptor UNC5B; p53RDL1; UNC5H2; 6330415E02Rik; A630020F16; D10Bwg0792e; Netrin receptor UNC5B Precursor; p53 regulated receptor for death and life; p53 regulated receptor for death and life protein 1; p53-regulated receptor for death and life protein 1; Protein unc-5 homolog 2; Protein unc-5 homolog B; Protein XUNC 5; Transmembrane receptor Unc5H2; Unc 5 homolog 2; Unc 5 homolog B; UNC 5B; UNC5B_HUMAN; unc-5 homolog 2; OTTHUMP00000019771; OTTHUMP00000019772
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • CHO
    • HEK293
    • HEK293T
    • Human Cell
    • Mammalian Cell
    • NS0
    • Tag :
    • Fc
    • hIgG/His
    • His
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Rat Unc5b-005R Recombinant Rat Unc5b Protein, hIgG/His-tagged HEK293 hIgG/His
    Mouse Unc5b-330M Recombinant Mouse Unc5b Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human UNC5B-2438H Recombinant Human Unc-5 Homolog B (C. Elegans), Fc Chimera CHO Fc
    Human Unc5b-2439M Recombinant Mouse Unc-5 Homolog B (C. Elegans), Fc Chimera HEK293 Fc
    Human UNC5B-31670TH Recombinant Human UNC5B, Fc-tagged HEK293 Fc
    Human UNC5B-555H Recombinant Human UNC5B Protein, Fc-tagged HEK293 Fc
    Human UNC5B-556H Recombinant Human UNC5B Protein, His-tagged HEK293 His
    Human UNC5B-634H Recombinant Human UNC5B Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Mouse UNC5B-17848M Recombinant Mouse UNC5B Protein Mammalian Cell His
    Rat UNC5B-101R Recombinant Rat Unc5b, Fc tagged Human Cell His
    Rat UNC5B-6451R Recombinant Rat UNC5B Protein Mammalian Cell His
    Rat UNC5B-767RCL Recombinant Rat UNC5B cell lysate Human Cell N/A
    Rat Unc5b-915R Recombinant Rat Unc5b Protein, Fc Chimera NS0 Fc
    Chicken UNC5B-2887C Recombinant Chicken UNC5B Mammalian Cell His
    Zebrafish UNC5B-6223Z Recombinant Zebrafish UNC5B Mammalian Cell His

    UNC5B involved in several pathways and played different roles in them. We selected most pathways UNC5B participated on our site, such as Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with UNC5B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Axon guidance EPHB4B; NFATC4; CSNK2B; MYL12B; CFL1; DUSP5; COL4A3; RHOA; SEMA3AB; NRG2A

    UNC5B has several biochemical functions, for example, netrin receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UNC5B itself. We selected most functions UNC5B had, and list some proteins which have the same functions with UNC5B. You can find most of the proteins on our site.

    Function Related Protein
    netrin receptor activity UNC5C; Unc5b
    protein binding KCTD15; Anks6; EHD1; C5orf13; DNM3; WBP1L; TEX19.1; UBA5; GAN; PITPNM3

    UNC5B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UNC5B here. Most of them are supplied by our site. Hope this information will be useful for your research of UNC5B.

    Agap2; Ppp2r1b

    Tu, T; Zhang, CX; et al. CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development. CELL RESEARCH 25:275-287(2015).
    Oksala, N; Parssinen, J; et al. Association of Neuroimmune Guidance Cue Netrin-1 and Its Chemorepulsive Receptor UNC5B With Atherosclerotic Plaque Expression Signatures and Stability in Human(s) Tampere Vascular Study (TVS). CIRCULATION-CARDIOVASCULAR GENETICS 6:579-587(2013).

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