vcl
Share
  • Official Full Name
  • vinculin
  • Background
  • Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
  • Synonyms
  • VCL; vinculin; MV; MVCL; CMD1W; CMH15; HEL114; metavinculin; epididymis luminal protein 114
Cat.#:VCL-118HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human VCL Protein, MYC/DDK-tagged
+Inquiry
Cat.#:VCL-01HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human VCL, His-tagged
+Inquiry
Cat.#:VCL-230HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human VCL protein
+Inquiry
Cat.#:VCL-3655HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human VCL, His-tagged
+Inquiry
Cat.#:VCL-68HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human VCL, His tagged
+Inquiry
Cat.#:VCL-7919HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human VCL
+Inquiry
Cat.#:Vcl-1869MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Vcl protein, His-tagged
+Inquiry
Cat.#:VCL-222MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Vcl, His tagged
+Inquiry
Cat.#:VCL-6507RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat VCL Protein
+Inquiry
Cat.#:VCL-6991CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken VCL
+Inquiry
Cat.#:VCL-899TTag:N/A
Source (Host):Turkey Smooth muscleSpecies:Turkey
Product nameNative Turkey VCL Protein
+Inquiry
Cat.#:VCL-1687HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human VCL cell lysate
+Inquiry
Cat.#:VCL-900MCLTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse VCL cell lysate
+Inquiry

Involved Pathway

VCL involved in several pathways and played different roles in them. We selected most pathways VCL participated on our site, such as Focal adhesion, Adherens junction, Leukocyte transendothelial migration, which may be useful for your reference. Also, other proteins which involved in the same pathway with VCL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Focal adhesion
PPP1CA; LAMA3; BIRC3; BCL2A; RAC1A; MAPK4; PARVG; PIK3CA; LAMC3; SRC
Adherens junction
SNAI1; INSR; PVRL3B; ACTN1; AASS; FGFR1; PTPN1; PVRL4; INSRB; PVRL1B
Leukocyte transendothelial migration
ACTB; JAM2; Itgam&Itgb2; THY1; CLDN17; MYLPF; CLDN20; GNAI2; NOX3; MMP9
Regulation of actin cytoskeleton
FGF3; PIP4K2AA; MAPK3; ROCK1; ABI2B; PIK3R1; RHOAC; ARPC5LA; ITGAL; ITGB1A
Bacterial invasion of epithelial cells
BCAR1; ILK; WASL; PIK3R3; ARPC5L; CLTB; SHC3; CBL; SRC; PIK3CD
Shigellosis
PFN3; NFKBIB; PFN1; UBE2D2; IKBKG; RIPK2; NFKB1; RELA; MAPK9; CDC42
Amoebiasis
COL24A1; IL12B; SERPINB6B; LAMB2; PTK2; LAMA4; FN1; GM-CSF; NOS2; CXCL8

Protein Function

VCL has several biochemical functions, for example, actin binding, NOT actin binding, alpha-catenin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by VCL itself. We selected most functions VCL had, and list some proteins which have the same functions with VCL. You can find most of the proteins on our site.
Function
Related Protein
Function actin binding
Related Protein PHACTR3B; SHANK3; GCSAM; GBP1; LRRC10; PHACTR3; TNS4; EPB41L3B; ADD3; KIF18A
Function NOT actin binding
Related Protein VCL
Function alpha-catenin binding
Related Protein CDH2; JUPA; CDH24; PKP2; JUB; AJUBA; CTNNB1; PKP3; VCL; JUP
Function beta-catenin binding
Related Protein LEF1; ASH2L; CALCOCO1; GSK3B; PTPRK; DACT3; DVL3; Ar; AXIN2; SLC9A3R2
Function cadherin binding
Related Protein CTNND1; NDRG1; CTNNAL1; CTNNB1; PROM1; FER; TBC1D2; CDK5R1; MMP24; JUP
Function dystroglycan binding
Related Protein AGR3; VCL; CLASP1; AGR2; DMD; DAG1; AGRN; MAP2; GYLTL1B
Function protein binding
Related Protein MLF1IP; CD200R3; TBC1D20; SMURF1; KARS; MET; NPEPL1; MTA1; CYTIP; PLEKHG2
Function structural molecule activity
Related Protein PRPH; KRT94; KRT84; COPB2; LCE1B; DCTN3; CDC42SE2; KRT31; SEPT7; CYT1L
Function ubiquitin protein ligase binding
Related Protein USP13; CKB; ARRB1; CCT2; GABARAPL1; LYN; SCN5A; ASB4; RALB; YWHAE

Interacting Protein

VCL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VCL here. Most of them are supplied by our site. Hope this information will be useful for your research of VCL.
ipaA; Sorbs1; ipaA; TEKT1; TRIP6; VCAM1; TLN1

VCL Related Articles

Liu, BJ; Tang, M; et al. Co-Incubation of Human Spermatozoa with Anti-VDAC Antibody Reduced Sperm Motility. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 33:142-150(2014).
Puard, V; Tranchant, T; et al. Semi-quantitative measurement of specific proteins in human cumulus cells using reverse phase protein array. REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY 11:-(2013).