| Description : |
Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
116.7 kDa |
| AA Sequence : |
MPVFHTRTIESILEPVAQQISHLVI MHEEGEVDGKAIPDLTAPVAAVQAA VSNLVRVGKETVQTTEDQILKRDMP PAFIKVENACTKLVQAAQMLQSDPY SVPARDYLIDGSRGILSGTSDLLLT FDEAEVRKIIRVCKGILEYLTVAEV VETMEDLVTYTKNLGPGMTKMAKMI DERQQELTHQEHRVMLVNSMNTVKE LLPVLISAMKIFVTTKNSKNQGIEE ALKNRNFTLEKMSAEINEIIRVLQL TSWDEDAWASKDTEAMKRALASIDS KLNQAKGWLRDPSASPGDAGEQAIR QILDEAGKVGELCAGKERREILGTC KMLGQMTDQVADLRARGQGSSPVAM QKAQQVSQGLDVLTAKVENAARKLE AMTNSKQSIAKKIDAAQNWLADPNG GPEGEEQIRGALAEARKIAELCDDP KERDDILRSLGEISALTSKLADLRR QGKGDSPEARALAKQVATALQNLQT KTNRAVANSRPAKAAVHLEGKIEQA QRWIDNPTVDDRGVGQAAIRGLVAE GHRLANVMMGPYRQDLLAKCDRVDQ LTAQLADLAARGEGESPQARALASQ LQDSLKDLKARMQEAMTQEVSDVFS DTTTPIKLLAVAATAPPDAPNREEV FDERAANFENHSGKLGATAEKAAAV GTANKSTVEGIQASVKTARELTPQV VSAARILLRNPGNQAAYEHFETMKN QWIDNVEKMTGLVDEAIDTKSLLDA SEEAIKKDLDKCKVAMANIQPQMLV AGATSIARRANRILLVAKREVENSE DPKFREAVKAASDELSKTISPMVMD AKAVAGNISDPGLQKSFLDSGYRIL GAVAKVREAFQPQEPDFPPPPPDLE QLRLTDELAPPKPPLPEGEVPPPRP PPPEEKDEEFPEQKAGEVINQPMMM AARQLHDEARKWSSKGNDIIAAAKR MALLMAEMSRLVRGGSGTKRALIQC AKDIAKASDEVTRLAKEVAKQCTDK RIRTNLLQVCERIPTISTQLKILST VKATMLGRTNISDEESEQATEMLVH NAQNLMQSVKETVREAEAASIKIRT DAGFTLRWVRKTPWYQTRTRPLEQK LISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
