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Official Full Name WNT1 inducible signaling pathway protein 2
Background This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover.
Synonyms WISP2; WNT1 inducible signaling pathway protein 2; WNT1-inducible-signaling pathway protein 2; CCN5; CT58; CTGF L; CCN family member 5; Connective tissue growth factor like protein; Connective tissue growth factor related protein 58; Connective tissue growth factor-like protein; Connective tissue growth factor-related protein 58; CTGF-L; WISP 2; WISP-2; WISP2_HUMAN; OTTHUMP00000031770; OTTHUMP00000063227; wnt-1 signaling pathway protein 2
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Human
    • Mammalian Cell
    • Yeast
    • Tag :
    • GST
    • His
    • SUMO
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse WISP2-1166M Recombinant Mouse WISP2 Protein (24-251 aa), His-SUMO-tagged E.coli His/SUMO
    Mouse WISP2-1754M Recombinant Mouse WISP2 Protein (24-251 aa), His-tagged Yeast His
    Human WISP2-307HCL Recombinant Human WISP2 293 Cell Lysate HEK293 N/A
    Human WISP2-30865TH Recombinant Human WISP2 E.coli N/A
    Human WISP2-30H Recombinant Human WISP2 protein, His-tagged E.coli His
    Human WISP2-3734H Recombinant Human WISP2, GST-tagged E.coli GST
    Human WISP2-644H Recombinant Human WNT1 Inducible Signaling Pathway Protein 2 Human N/A
    Human WISP2-932H Recombinant Human WNT1 Inducible Signaling Pathway Protein 2 E.coli N/A
    Rat WISP2-31R Recombinant Rat Wisp2 protein, His-tagged E.coli His
    Rat Wisp2-591R Recombinant Rat Wisp2 Protein, His-tagged E.coli His
    Rat WISP2-6595R Recombinant Rat WISP2 Protein Mammalian Cell His
    Zebrafish WISP2-7845Z Recombinant Zebrafish WISP2 Mammalian Cell His

    WISP2 involved in several pathways and played different roles in them. We selected most pathways WISP2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with WISP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    WISP2 has several biochemical functions, for example, heparin binding, insulin-like growth factor binding, integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WISP2 itself. We selected most functions WISP2 had, and list some proteins which have the same functions with WISP2. You can find most of the proteins on our site.

    Function Related Protein
    heparin binding CYR61; REG4; PCOLCE; THBS4; CCL8; HRG; NDNF; SOST; VTN; VEGFAA
    insulin-like growth factor binding IGFBP5A; ESM1; WISP3; WISP1; CTGFA; IGFBP7; IGFALS; IGF1RA; WISP1A; HTRA1
    integrin binding TSPAN4; TIMP2; ITGA5; NOV; PPAP2B; S1PR2; ESM1; COL3A1; LAMA5; ITGA6

    WISP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WISP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of WISP2.

    TFAP2A; syd; fliH; TFAP2C

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