ABCC1
-
Official Full Name
ATP-binding cassette, sub-family C (CFTR/MRP), member 1
-
Overview
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternative splicing by exon deletion results in several splice variants but maintains the original open reading frame in all forms. -
Synonyms
ABCC1; ATP-binding cassette, sub-family C (CFTR/MRP), member 1; MRP, MRP1, multidrug resistance associated protein 1; multidrug resistance-associated protein 1; GS X; LTC4 transporter; leukotriene C(4) transporter; ATP-binding cassette transporter varian;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Cynomolgus Monkey
- Human
- Mouse
- Rat
- E. coli
- E.coli
- HEK293
- Mammalian Cell
- Wheat Germ
- C
- His
- GST
- His (Fc)
- Avi
- His|T7
- Involved Pathway
- Protein Function
- Interacting Protein
- ABCC1 Related Articles
- ABCC1 Related Research Area
ABCC1 involved in several pathways and played different roles in them. We selected most pathways ABCC1 participated on our site, such as ABC transporters, Sphingolipid signaling pathway, Vitamin digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ABC transporters | ABCG3;ABCA13;ABCC4;ABCC1;ABCB1A;ABCC2;ABCC5;ABCB10;ABCB1LB |
| Sphingolipid signaling pathway | SGPP2;PPP2R5C;PLD1;PIK3R5;PIK3R2;ABCC1;BDKRB2;MS4A2;ROCK1 |
| Vitamin digestion and absorption | APOB;TCN2;MMACHC;SLC52A3;SLC19A2;LRAT;SLC19A3;GIF;SLC19A1 |
| MicroRNAs in cancer | PLCG1;NFKB1;TRIM71;CCNE1;UBE2I;PDGFRA;NOTCH1;SIRT1;ST14 |
ABCC1 has several biochemical functions, for example, ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCC1 itself. We selected most functions ABCC1 had, and list some proteins which have the same functions with ABCC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | KIF2C;SEPHS2;EHD2;CPS1;TNK2;DDX27;MYH9;MCM3;KIF14 |
| ATPase activity | INO80;ATAD1;NSFA;MLH3;MYO9B;ABCA1B;VCP;VWA8;ATP13A |
| ATPase activity, coupled to transmembrane movement of substances | ABCC3;ABCD1;ABCB6;ABCB5;ABCB10;ABCC10;Abca2;ABCA8;ABCA4 |
| transporter activity | ABCA4A;SLC5A8;AQP10B;SLC25A38B;SLC12A10.1;FABP7;SLC13A5A;KIF20A;SLC17A9B |
ABCC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCC1.
NPM1; AZGP1; TRAF3; Kcnk1; TMEM173; Unc93b1
- Q&As
- Reviews
Q&As (16)
Ask a questionYes, you can communicate with our experts about specific customization needs.
In-stock products will be shipped as soon as possible after your purchase, and the specific arrival time will vary from address to address.
Our product manuals generally include relevant information, or you can contact our technical experts at any time and they will be able to give you relevant assistance.
You can communicate directly with our experts.
Yes, ABCC1 protein, including custom-produced ABCC1 protein, is participating in this promotion.
Our experts can advise on your research needs.
Protein purification is generally performed by hydrophobic chromatography, affinity chromatography, ion exchange chromatography, salting out, molecular sieve, etc.
We offer a wide range of protein expression systems, including common bacterial expression systems, baculovirus-insect cell expression systems, cell-free in vitro protein expression systems, mammalian expression systems, yeast expression systems, etc.
ABCC1 protein is ubiquitously expressed in most normal tissues.
You can communicate directly with us about your specific purchase needs, and we will determine if there is a discount based on the actual situation.
We also offer ABCC2, ABCC3, ABCC4, ABCC6 proteins, or you can get the protein you need through our custom protein production service.
Membrane can be blocked in 5% milk before incubation with primary antibody.
Generally, nitrocellulose membrane and PVDF membrane are used for Western Blot.
Several studies have shown that multidrug resistance is associated with enhanced ABCC1 protein expression.
Yes, ABCC1 causes resistance to natural product drugs such as epipodophyllotoxins, vinca alkaloids and certain anthracyclines.
ABCC1-6, ABCC10-13 all belong to the MRP family.
Customer Reviews (5)
Write a reviewThe protein meets the custom requirements, great price and the technician can give me professional help.
The technicians provided me with a lot of after-sales help, and the bands obtained for WB are also very clear.
Just participated in this promotion. High protein purity and good experimental results.
Right price, fast delivery and good after-sales service.
Fast delivery and high quality product.
Ask a Question for All ABCC1 Products
Required fields are marked with *
My Review for All ABCC1 Products
Required fields are marked with *
