ABCC3
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Official Full Name
ATP-binding cassette, sub-family C (CFTR/MRP), member 3
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Overview
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. -
Synonyms
ABCC3; ATP-binding cassette, sub-family C (CFTR/MRP), member 3; canalicular multispecific organic anion transporter 2; cMOAT2; EST90757; MLP2; MOAT D; MRP3; ABC 31; ABC31; ABCC 3; ATP binding cassette sub family C (CFTR/MRP) member 3; ATP binding cassette sub family C; ATP binding cassette sub family C member 3; ATP-binding cassette sub-family C member 3; Canicular multispecific organic anion transporter; CMOAT 2; MLP 2; MOAT-D; MOATD; MRP 3; MRP3_HUMAN; Multi specific organic anion transporter D; Multi-specific organic anion transporter D; Multidrug resistance associated protein 3; Multidrug resistance associated protein; Multidrug resistance-associated protein 3; Multispecific organic anion tranporter D; OTTHUMP00000221667; OTTHUMP00000221668; OTTHUMP00000221670; multi-specific orga;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E. coli
- E.coli
- HEK293
- Mammalian Cell
- C
- His
- His (Fc)
- Avi
- His|T7
- N/A
- N
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | ABCC3-8118H | Recombinant Human ABCC3 protein, His & T7-tagged | E.coli | His/T7 | Phe1291~Asp1523 (Accession # O15438) |
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| Human | ABCC3-9150HCL | Recombinant Human ABCC3 293 Cell Lysate | HEK293 | N/A |
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| Human | ABCC3-2466H | Recombinant Human ABCC3 protein(871-950 aa), C-His-tagged | E. coli | C-His | 871-950 aa |
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| Human | ABCC3-0440H | Recombinant Human ABCC3 Protein (Phe1291-Asp1523), N-His-tagged | E.coli | N-His | Phe1291-Asp1523 |
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| Mouse | ABCC3-1101M | Recombinant Mouse ABCC3 Protein | Mammalian Cell | His |
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| Mouse | ABCC3-198M | Recombinant Mouse ABCC3 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Mouse | ABCC3-198M-B | Recombinant Mouse ABCC3 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rat | ABCC3-405R | Recombinant Rat ABCC3 Protein | Mammalian Cell | His |
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| Rat | ABCC3-60R | Recombinant Rat ABCC3 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rat | ABCC3-60R-B | Recombinant Rat ABCC3 Protein Pre-coupled Magnetic Beads | HEK293 |
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- Involved Pathway
- Protein Function
- Interacting Protein
- ABCC3 Related Articles
ABCC3 involved in several pathways and played different roles in them. We selected most pathways ABCC3 participated on our site, such as ABC transporters, Bile secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ABC transporters | ABCB6A;ABCC6;TAP2;ABCB7;ABCA8;ABCA3;ABCB11;ABCA4;ABCG2 |
| Bile secretion | ABCB1A;ABCB11;SLC5A1;NCEH1;SLC9A3;OSTB;HMGCR;KCNN2;SLCO1B3 |
ABCC3 has several biochemical functions, for example, ATP binding, ATPase activity, coupled to transmembrane movement of substances, organic anion transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCC3 itself. We selected most functions ABCC3 had, and list some proteins which have the same functions with ABCC3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | NAIP7;LATS1;LCK;BSK146;SRR;KIF1B;DDX23;UBE2IB;MAP3K4 |
| ATPase activity, coupled to transmembrane movement of substances | ABCB10;ABCD4;ABCD1;ABCD3A;ABCC9;ABCA1;ABCB6;ABCB7;ABCB8 |
| organic anion transmembrane transporter activity | SLCO1A5;SLC22A6;SLCO3A1;ABCC2;SLCO1B3;SLC22A7B.1;SLCO1B2;SLCO1A2;SLC22A17 |
ABCC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCC3.
MLH1; ubiF; q81sm8_bacan; q8czu9_yerpe; tadA
- Q&As
- Reviews
Q&As (14)
Ask a questionNeed more evidence. The expression of ABCC3 is associated with poor survival and impaired response to temozolomide. Importantly, high expression of ABCC3 is restricted to glioblastoma, with negligible levels in healthy brain tissue, and further correlates with tumor grade and stemness markers.
Not all the tumour.Some research shows that pharmacological inhibition of ABCC3 slows tumour progression in animal models of pancreatic cancer.
ABCC3 expression is regulated by mutant p53 via miR-34 and that the transporter drives PDAC progression via transport of the bioactive lipid lysophosphatidylinositol (LPI)
Lots of proteins interact with ABCC3. Such as proteins involved in transport and metabolism,ABCB1 (P-glycoprotein) and ABCG2
ABCC3 was overexpressed in EOC tumors, but after the treatment with taxanes, its up-regulation disappeared.
ABCC3 has been found highly expressed in different types of cancers and is associated with poor prognosis and resistance to treatments. Some researchs provide evidences that place ABCC3 as a potential therapeutic target for improving the cancer treatment.
The crystal structure of ABCC3 has not yet been determined. However, there have been studies using cryo-electron microscopy (cryo-EM) to determine the structure of ABCC3 in complex with various ligands, such as leukotriene C4 (LTC4) and S-(2,4-dinitrophenyl)glutathione (DNP-SG).
The expression level of the ABCC3 gene in glioma tissues was lower than that of corresponding normal brain tissues.The overall survival and disease-free survival of in the ABCC3 low-expression group was significant decreased.
MK571,Probenecid,Cepharanthine,Quinoline-based compounds
Overexpression of ABCC3 promotes cell proliferation, drug resistance, and aerobic glycolysis and is associated with poor prognosis in urinary bladder cancer patients.
Different cells and functions participate in different signal pathways. For example,Wnt signaling represses ABCC3 expression during colon carcinogenesis.
ABCC3 is frequently amplified and overexpressed in HER2-positive breast cancer.
The expression of ABCB1, ABCC1, ABCC2, ABCC3, and ABCG2 was altered in association with colon carcinogenesis.
Not sure,need more evidence.Some result shows that intestinal absorption of cefadroxil depends partly on ABCC3 and ABCC4.
Customer Reviews (3)
Write a reviewGifts with goods are very practical
Good repeatability of experimental results
High purity, good
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