ABCC5
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Official Full Name
ATP-binding cassette, sub-family C (CFTR/MRP), member 5
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Overview
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear. -
Synonyms
ABCC5; ATP-binding cassette, sub-family C (CFTR/MRP), member 5; multidrug resistance-associated protein 5; EST277145; MOAT C; MRP5; SMRP; ATP-binding cassette sub-family C member 5; multi-specific organic anion transporter C; canalicular multispecific org;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- HEK293
- In Vitro Cell Free System
- Mammalian cell
- Mammalian Cell
- Wheat Germ
- eGFP, Strep II,10His
- GST
- His
- His (Fc)
- Avi
- Involved Pathway
- Protein Function
- Interacting Protein
- ABCC5 Related Articles
ABCC5 involved in several pathways and played different roles in them. We selected most pathways ABCC5 participated on our site, such as ABC transporters, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCC5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ABC transporters | ABCC8;ABCB3L1;ABCB5;ABCC2;ABCA8;ABCD2;ABCB1LB;ABCB1A;ABCC6 |
ABCC5 has several biochemical functions, for example, ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCC5 itself. We selected most functions ABCC5 had, and list some proteins which have the same functions with ABCC5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | RPS6KA3;CLPXA;DICER1;ACTG2;DCLK2;CHD1L;CSNK2A2A;PI4KB;P2RX8 |
| ATPase activity | ASNA1;KIF6;RALBP1;DYNC2H1;KIF4A;ATAD1;DNA2;KIF25;PSMC1 |
| ATPase activity, coupled to transmembrane movement of substances | ABCC10;ABCB6A;ABCC2;ABCD3B;ABCD4;ABCC9;ABCD3;SFRP5;ABCA4 |
| nucleotide binding | PFKMA;SAFB;NME2B.1;TUBA8L3;NT5C3A;TRIOA;NAIP1;MYH4;PABPC3 |
| organic anion transmembrane transporter activity | MFSD10;SLCO4C1;SLCO1B3;ABCC11;SLC22A31;SLCO1D1;ABCC3;SLCO3A1;SLC22A6 |
ABCC5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCC5 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCC5.
- Q&As
- Reviews
Q&As (16)
Ask a questionProgesterone, testosterone and their analogues
No clear research results. But the down-regulation of ABCC5 expression could significantly reduce the resistance of sorafenib to HCC cells.
The expression levels of ABCC2, ABCC4, ABCC5, and ABCG2 significantly increased in the pan-resistant cell line, and the ABCC5 level in the MCF-7-ADR cell line was 5.21 times higher than that in the control group.
MRP4 (ABCC4) and MRP5 (ABCC5) are organic anion transporters.
PLEKHA7, ABCC5, and KALRN have been identified as susceptible genetic markers related to glaucoma.
There is no clear result now. Some research show that ABCC5 was differently expressed and strongly related to the pathological stage of LIHC.
Not in all the tumors. Small molecular inhibitors of FOXM1 or ABCC5 have the potential to overcome paclitaxel chemoresistance in nasopharyngeal carcinoma patients
The role of ABCC5 in diabetes and obesity is unknown. ABCC5 protein expression levels are inversely related to fat mass and appear to play a role in the regulation of GLP-1 secretion from enteroendocrine cells.
No result shows that ABCC5 mutation will lead to diabetes. Research shows that ABCC5 transporter is a new type 2 diabetes susceptibility gene
Some study demonstrated that ABCC5 knockdown significantly inhibits PCa cell proliferation, migration, and invasion in vitro and suppresses tumor growth and metastasis in vivo.
It has not yet been reported.
There are many polymorphisms on ABCC5, such as, ABCC5 g.+7161G>A (rs1533682),g.+7161AA,g.+7161GG,g.-1679T>A, c.2T>C, c.343A>G, and c.1573G>A.
More research data are needed to prove.A study shows that the expression of ABCC5 was up-regulated in HCC and was associated with poor prognosis.
The protein is widely expressed in various tissues, with particularly high levels observed in the liver, kidney, and prostate.
Yes, please contact us for more information.
In adults, zebrafish abcc5 is extensively expressed, at higher levels in testis, brain, eye, ovary, intestine and kidney, but at relatively lower levels in gill, liver, heart and muscle.
Customer Reviews (3)
Write a reviewReasonable price and high quality
It is cost-effective to buy when promoting
There are many expression systems to choose from
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